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The map label for this gene is vraR [H]

Identifier: 37523666

GI number: 37523666

Start: 4295272

End: 4295949

Strand: Reverse

Name: vraR [H]

Synonym: gll4097

Alternate gene names: 37523666

Gene position: 4295949-4295272 (Counterclockwise)

Preceding gene: 37523667

Following gene: 37523665

Centisome position: 92.21

GC content: 63.86

Gene sequence:

>678_bases
TTGACCGTCCAGACCATCCTGCCCATCTTGCTCGTCGACGACGAATTGCGCTTTCGTCAGGGTCTGCGCACGCTGCTCAG
TTTCTACAGCGCCACCGGCACCACCACCTTTGAGATCGTGGGCGAGGCGGCCACCGTCGATCAGGCGCTGACCCTCATTC
ACTCCCAGCGCCCGGCCCTGGTGCTTTTAGATCTCGAACTGGCCCAAGGAGACGGGGTGGAGTTGCTCACCCGCCTCAGG
GGGAGCGCTTTCGCGGGCAAGGTGCTGGTGCTCTCGGCCCACCAGGAGGACGACTGGGTCTTTCGCGCCATGCAGTCGGG
CGCGTCGGGCTATGTCTTCAAGACCCACCTGGCCGCCCAGCTGTGTGCCGCCATCACCACGGTCCTGCGCGACGAAATCT
ATTTGCCCCCCGAGGTGGCGACCCAGTTCTTCCGGCTGTTCCACTACTACGCGGGGCATACCGTGCAGTCGCGCTCGCGC
ATTCACCTGACCGAGCGCGAGCAGGAAGTGCTCCACTGGCTGGTGCGCGGCGCCTCCAACGACGAAATCGCCCGCAACCT
CTACATCACGATTGCCACAGTCAAAGCGCACCTTTCGGCCATCTTCGAAAAACTCCAGGTCACCAGCCGCACCCAGGCCA
TCGTCGCCGCCCTCAAACTCGGCCTGGTGCAGGCTTGA

Upstream 100 bases:

>100_bases
GGCAGCCTCTGGGTGCAAAATCTACCCACCGGCGGCGCCCAATTTTCCCTAGGTCTCCCTCGCGGCATCCATTGAACTGC
CGACGCCGAGGAGGTCCGCC

Downstream 100 bases:

>100_bases
TAGCGCTACAGTAAAAAGTAGCGAGGACACAGCGAGCATGGAGAGCGGATCCGTTGCGCTTACCCACGAAGAAAACGAAG
CCTTAGATAGAATTGCTCAG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTVQTILPILLVDDELRFRQGLRTLLSFYSATGTTTFEIVGEAATVDQALTLIHSQRPALVLLDLELAQGDGVELLTRLR
GSAFAGKVLVLSAHQEDDWVFRAMQSGASGYVFKTHLAAQLCAAITTVLRDEIYLPPEVATQFFRLFHYYAGHTVQSRSR
IHLTEREQEVLHWLVRGASNDEIARNLYITIATVKAHLSAIFEKLQVTSRTQAIVAALKLGLVQA

Sequences:

>Translated_225_residues
MTVQTILPILLVDDELRFRQGLRTLLSFYSATGTTTFEIVGEAATVDQALTLIHSQRPALVLLDLELAQGDGVELLTRLR
GSAFAGKVLVLSAHQEDDWVFRAMQSGASGYVFKTHLAAQLCAAITTVLRDEIYLPPEVATQFFRLFHYYAGHTVQSRSR
IHLTEREQEVLHWLVRGASNDEIARNLYITIATVKAHLSAIFEKLQVTSRTQAIVAALKLGLVQA
>Mature_224_residues
TVQTILPILLVDDELRFRQGLRTLLSFYSATGTTTFEIVGEAATVDQALTLIHSQRPALVLLDLELAQGDGVELLTRLRG
SAFAGKVLVLSAHQEDDWVFRAMQSGASGYVFKTHLAAQLCAAITTVLRDEIYLPPEVATQFFRLFHYYAGHTVQSRSRI
HLTEREQEVLHWLVRGASNDEIARNLYITIATVKAHLSAIFEKLQVTSRTQAIVAALKLGLVQA

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=215, Percent_Identity=29.7674418604651, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1787473, Length=215, Percent_Identity=32.093023255814, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1788222, Length=220, Percent_Identity=25.4545454545455, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1786747, Length=161, Percent_Identity=32.2981366459627, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1788712, Length=200, Percent_Identity=23.5, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790102, Length=205, Percent_Identity=27.8048780487805, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1787277, Length=188, Percent_Identity=29.2553191489362, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24988; Mature: 24857

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQTILPILLVDDELRFRQGLRTLLSFYSATGTTTFEIVGEAATVDQALTLIHSQRPAL
CCHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCEE
VLLDLELAQGDGVELLTRLRGSAFAGKVLVLSAHQEDDWVFRAMQSGASGYVFKTHLAAQ
EEEEEEECCCCCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHH
LCAAITTVLRDEIYLPPEVATQFFRLFHYYAGHTVQSRSRIHLTEREQEVLHWLVRGASN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCCC
DEIARNLYITIATVKAHLSAIFEKLQVTSRTQAIVAALKLGLVQA
CHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVQTILPILLVDDELRFRQGLRTLLSFYSATGTTTFEIVGEAATVDQALTLIHSQRPAL
CHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCEE
VLLDLELAQGDGVELLTRLRGSAFAGKVLVLSAHQEDDWVFRAMQSGASGYVFKTHLAAQ
EEEEEEECCCCCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHH
LCAAITTVLRDEIYLPPEVATQFFRLFHYYAGHTVQSRSRIHLTEREQEVLHWLVRGASN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCCC
DEIARNLYITIATVKAHLSAIFEKLQVTSRTQAIVAALKLGLVQA
CHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]