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The map label for this gene is yahK [C]

Identifier: 37523680

GI number: 37523680

Start: 4306802

End: 4307821

Strand: Reverse

Name: yahK [C]

Synonym: gll4111

Alternate gene names: 37523680

Gene position: 4307821-4306802 (Counterclockwise)

Preceding gene: 37523682

Following gene: 37523667

Centisome position: 92.46

GC content: 65.78

Gene sequence:

>1020_bases
ATGACTAAGATGCGCGCCATGATCGTACCTGAAGCGGGCGCGAAGTTTCAGATGATCGAGCGGGATTTGCCCGTACCCGG
GCCGCGGGAGGTCCGGCTGAGCGTCAGCGCCTGTGGCGTGTGTCACAGCGACTCTGTGACGGTCGAAGGGACGATGCGGG
GCATCGCCTATCCGCGCGTGCCCGGCCATGAGGTGATCGGCACGATCGAGGCGCTCGGGCCAGAGGTGCTCGGCTGGGAG
GTGAGCATGCGCGTCGGCGTCGGTTGGTTCGGCGGCTCGTGTGGGTATTGCGCGCACTGCCGACGCGGCTCGGCGTTCGC
CTGCGAGACGGTGAGCGCCGTCACCGGTGTGACCCGCGACGGCGGCTACGCGACCCACATGCTGGCCGATGTCTCCGCGC
TCGCCCATGTGCCGACCGATCTCGACGTGGTCGAATCGGCGCCCTTACTGTGTGCCGGTATCACCACCTTCAACGCGCTG
CGCAATTGCGGTGCGGGGCCGGGCGAGTTGGTGGCGATCCACGGTATCGGCGGGCTCGGTCATCTCGGTATCCAGTTCGC
CGCGCGCCAGGGCTTCCGCACCGTCGCCGTCAACCGCGGCCGCGACAAAGAGGAACTCGCACGCTCGCTCGGCGCGCACG
AATACATCGACAGCGAAGAGGGCGATCCCGCCGCCGCACTGCTGGCGATGGGCGGGGCAAAGGCGATCCTCGCAACCGTC
ACCAGCGAGAAAGCGATGCAGGCGCTCGTTGGCGGTCTCGGACCCAACGGCACGATGATGCTCATCGGTGCAGTGCCCAC
CCTCACTGTCAACCCGACAGAGTTACTCCTCAAGCGCGCCGCGGTGAAGGGCTGGTATTCGGGCACGGCGGCCGATTCGG
AGGATACACTGCTGTTTAGCCATCGCAACGGGATCACCTCCATGAACGAAATCTACCCGTTCGAGAACGCACAGGCTGCA
TACGATCGGATGATGAGCGGCAAGGCGCGCTTTCGCGTCGTCCTTTCGATGGGGGTGTAA

Upstream 100 bases:

>100_bases
GGCCGATCAGGAGATCGAGGCAGCACTCCCGAACGAAGACCAAACATGAATATCGCTGGGCGGTTACTCCCATCAACAGA
TAGATGGAGAAGATATAACA

Downstream 100 bases:

>100_bases
CAACTCGCGCCGTCATCGTGCAAGCGCACCAAGACGGCTGCGGCTTGGTACTGTAGAAGATTGCAGGCAGCCAGAGAACG
CTTGTCTATTGGTTCATCGT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTKMRAMIVPEAGAKFQMIERDLPVPGPREVRLSVSACGVCHSDSVTVEGTMRGIAYPRVPGHEVIGTIEALGPEVLGWE
VSMRVGVGWFGGSCGYCAHCRRGSAFACETVSAVTGVTRDGGYATHMLADVSALAHVPTDLDVVESAPLLCAGITTFNAL
RNCGAGPGELVAIHGIGGLGHLGIQFAARQGFRTVAVNRGRDKEELARSLGAHEYIDSEEGDPAAALLAMGGAKAILATV
TSEKAMQALVGGLGPNGTMMLIGAVPTLTVNPTELLLKRAAVKGWYSGTAADSEDTLLFSHRNGITSMNEIYPFENAQAA
YDRMMSGKARFRVVLSMGV

Sequences:

>Translated_339_residues
MTKMRAMIVPEAGAKFQMIERDLPVPGPREVRLSVSACGVCHSDSVTVEGTMRGIAYPRVPGHEVIGTIEALGPEVLGWE
VSMRVGVGWFGGSCGYCAHCRRGSAFACETVSAVTGVTRDGGYATHMLADVSALAHVPTDLDVVESAPLLCAGITTFNAL
RNCGAGPGELVAIHGIGGLGHLGIQFAARQGFRTVAVNRGRDKEELARSLGAHEYIDSEEGDPAAALLAMGGAKAILATV
TSEKAMQALVGGLGPNGTMMLIGAVPTLTVNPTELLLKRAAVKGWYSGTAADSEDTLLFSHRNGITSMNEIYPFENAQAA
YDRMMSGKARFRVVLSMGV
>Mature_338_residues
TKMRAMIVPEAGAKFQMIERDLPVPGPREVRLSVSACGVCHSDSVTVEGTMRGIAYPRVPGHEVIGTIEALGPEVLGWEV
SMRVGVGWFGGSCGYCAHCRRGSAFACETVSAVTGVTRDGGYATHMLADVSALAHVPTDLDVVESAPLLCAGITTFNALR
NCGAGPGELVAIHGIGGLGHLGIQFAARQGFRTVAVNRGRDKEELARSLGAHEYIDSEEGDPAAALLAMGGAKAILATVT
SEKAMQALVGGLGPNGTMMLIGAVPTLTVNPTELLLKRAAVKGWYSGTAADSEDTLLFSHRNGITSMNEIYPFENAQAAY
DRMMSGKARFRVVLSMGV

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=25.201072386059, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI34577061, Length=383, Percent_Identity=23.7597911227154, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=25.0673854447439, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI262073058, Length=372, Percent_Identity=23.6559139784946, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI71743840, Length=372, Percent_Identity=23.6559139784946, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI194239674, Length=348, Percent_Identity=25, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI13236495, Length=348, Percent_Identity=25, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI71565154, Length=374, Percent_Identity=24.331550802139, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786518, Length=323, Percent_Identity=35.9133126934984, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI87082401, Length=339, Percent_Identity=32.4483775811209, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI87081918, Length=311, Percent_Identity=28.9389067524116, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI226510992, Length=311, Percent_Identity=25.4019292604502, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082125, Length=349, Percent_Identity=27.2206303724928, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787863, Length=280, Percent_Identity=27.1428571428571, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790045, Length=329, Percent_Identity=24.0121580547112, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788073, Length=336, Percent_Identity=25.8928571428571, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788075, Length=266, Percent_Identity=24.812030075188, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788407, Length=244, Percent_Identity=27.0491803278689, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786552, Length=245, Percent_Identity=28.9795918367347, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=343, Percent_Identity=28.8629737609329, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17562582, Length=329, Percent_Identity=28.5714285714286, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71988145, Length=340, Percent_Identity=25.8823529411765, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=377, Percent_Identity=24.6684350132626, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=32.0588235294118, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324486, Length=342, Percent_Identity=32.4561403508772, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6323961, Length=340, Percent_Identity=32.3529411764706, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6323729, Length=341, Percent_Identity=31.3782991202346, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323980, Length=323, Percent_Identity=28.4829721362229, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319949, Length=336, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=376, Percent_Identity=25.2659574468085, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17737895, Length=367, Percent_Identity=24.2506811989101, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35521; Mature: 35390

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00059 ADH_ZINC ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKMRAMIVPEAGAKFQMIERDLPVPGPREVRLSVSACGVCHSDSVTVEGTMRGIAYPRV
CCCCEEEEECCCCCCEEEHHCCCCCCCCCEEEEEEEECCEECCCCEEEEEEECCEECCCC
PGHEVIGTIEALGPEVLGWEVSMRVGVGWFGGSCGYCAHCRRGSAFACETVSAVTGVTRD
CCHHHHHHHHHCCCCCEEEEEEEEEEEEEECCCCCHHHHCCCCCCCHHHHHHHHHCCCCC
GGYATHMLADVSALAHVPTDLDVVESAPLLCAGITTFNALRNCGAGPGELVAIHGIGGLG
CCHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEHHHHHHHHHHCCCCCCCEEEEECCCCCH
HLGIQFAARQGFRTVAVNRGRDKEELARSLGAHEYIDSEEGDPAAALLAMGGAKAILATV
HHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCHHCCCCCCCCHHHHHHHHCCCCEEEEEH
TSEKAMQALVGGLGPNGTMMLIGAVPTLTVNPTELLLKRAAVKGWYSGTAADSEDTLLFS
HHHHHHHHHHCCCCCCCCEEEEECCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
HRNGITSMNEIYPFENAQAAYDRMMSGKARFRVVLSMGV
CCCCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
TKMRAMIVPEAGAKFQMIERDLPVPGPREVRLSVSACGVCHSDSVTVEGTMRGIAYPRV
CCCEEEEECCCCCCEEEHHCCCCCCCCCEEEEEEEECCEECCCCEEEEEEECCEECCCC
PGHEVIGTIEALGPEVLGWEVSMRVGVGWFGGSCGYCAHCRRGSAFACETVSAVTGVTRD
CCHHHHHHHHHCCCCCEEEEEEEEEEEEEECCCCCHHHHCCCCCCCHHHHHHHHHCCCCC
GGYATHMLADVSALAHVPTDLDVVESAPLLCAGITTFNALRNCGAGPGELVAIHGIGGLG
CCHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEHHHHHHHHHHCCCCCCCEEEEECCCCCH
HLGIQFAARQGFRTVAVNRGRDKEELARSLGAHEYIDSEEGDPAAALLAMGGAKAILATV
HHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCHHCCCCCCCCHHHHHHHHCCCCEEEEEH
TSEKAMQALVGGLGPNGTMMLIGAVPTLTVNPTELLLKRAAVKGWYSGTAADSEDTLLFS
HHHHHHHHHHCCCCCCCCEEEEECCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
HRNGITSMNEIYPFENAQAAYDRMMSGKARFRVVLSMGV
CCCCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]