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The map label for this gene is tuaD [H]

Identifier: 37523288

GI number: 37523288

Start: 3931090

End: 3932478

Strand: Reverse

Name: tuaD [H]

Synonym: gll3719

Alternate gene names: 37523288

Gene position: 3932478-3931090 (Counterclockwise)

Preceding gene: 37523289

Following gene: 37523287

Centisome position: 84.41

GC content: 64.72

Gene sequence:

>1389_bases
ATGAAAGTAGGGGTTATCGGCACCGGTTACGTCGGCCTGGTCACAGGCGCCTGCCTGGCCACCATCGGCCATCATGTCGT
GTGCATGGACAACAACACCGCCAAAGTCGAAGGCTTGCGCCAGGGCGTCATGCCCATCTACGAACCCGGGCTCGACGCGT
TGGTCGCCGCCGCCGTCGCTACGGGGCAGCTGCAGTTCACCACCGAGATGGCCGAGACCGTTCGCCCGAGCGATGTGGTC
TTCATCACCGTCGGTACCCCCTCCAGGGCGGACGGCTCACCGGATCTTTCTGCCGTGCGCGCCGTGGCCCGCGCGATCGG
CGCCCACCTCGACGGACGCTTTCGGGTGGTGGTGAATAAATCGACCGTGCCGGTGGGCTCCGGTAACTGGGTGCGCATGC
TGGTCGAAGACGGCGCGAACCTCGCCGCCGCCACCGCCGGAAGCAGCCACTACACGGGTAACGGTCTGGCGGTGCTCTCG
CCTGGGGAGCCGCCGAACTTCAGTGTGGCGAGCAACCCGGAATTTTTGCGTGAAGGCAGTGCCGTCTGGGACACCTTCAA
CCCCGACCGCATCGTCATCGGTGCGGAAGATGTCAAAGCGATCGCCGTCATGCGCAAGCTCTACGCTTACTGGCTTGCCC
CCGAGCAAGCCGATCGCGAGCCGGTGCCGATGGTGGTGACGGACTTGGCCTCCGCCGAGATGATCAAGTACGCCGCCAAC
GCCTTTCTGGCCACCAAAATCAGCTTCATCAACGAAATCGCCAACATCTGCGAACGGGTCGGTGCCGATGTCACCCGCAT
TGCTGAAGCGATCGGACTCGACAAGCGCATCGGCCGCTCGTTTCTGAACGCCGGGGCGGGCTGGGGCGGTTCGTGCTTTC
CAAAAGACGTCTCGGCCCTGGTCTCGACGGCGGCTGAGTATGGCCACGACTGCGAGTTGCTGAAGGCGACCTTGTCGGTC
AACGAGCACCAGCGCCAACTGGTGATCGAGAAATTGCAGCGGGAGCTGCGCATTCTCAAGGGTCGGACGGTGGCGCTGTG
GGGATTGGCCTTCAAACCGCACACCGACGACATCCGTTGCGCGCCGGCGTTGGCGGTGGCGGAGCATCTATTGAATCTCG
GTTGCCGGGTGGTGGCCCACGACCCGGTGGTGACGGCGGCCCAGGTGCAAGGTCAACTGCCGGACTTGCAAGTGGCGGGT
AGTGCTCTGGAGGCTGTCCAGGGGGCCGATGCGCTGTTGGTGATGACCGAGTGGCCCGAGTATACGCGGGTGAATCTGGG
GGTGGTGGCGGCGGGACTGCGCCAGCCGGTAGTCATCGACGCGCGCAACTGCCTCGACCCGCAGCAGGTGGTACAGGCGG
GTATGCGTTACTCGGGCGTCGGTCGCTAG

Upstream 100 bases:

>100_bases
GCGCGAAATTGGGCCTGGGCTTTCTGACGACCCTGCCTGACAGCGAGCCGACCTGATTTGTCCGTGTCCACATTATTTAT
GCCCATCGCAAGGAGCATCC

Downstream 100 bases:

>100_bases
CCACAGGCATCAAGGGAGCGAAATCCATGACGATATTTAGGCAAGCGCGCTTTCCGGTAGTCCATCGGCCACCTTCCAGT
GGCGGCGAACCGCTGGTCAG

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKVGVIGTGYVGLVTGACLATIGHHVVCMDNNTAKVEGLRQGVMPIYEPGLDALVAAAVATGQLQFTTEMAETVRPSDVV
FITVGTPSRADGSPDLSAVRAVARAIGAHLDGRFRVVVNKSTVPVGSGNWVRMLVEDGANLAAATAGSSHYTGNGLAVLS
PGEPPNFSVASNPEFLREGSAVWDTFNPDRIVIGAEDVKAIAVMRKLYAYWLAPEQADREPVPMVVTDLASAEMIKYAAN
AFLATKISFINEIANICERVGADVTRIAEAIGLDKRIGRSFLNAGAGWGGSCFPKDVSALVSTAAEYGHDCELLKATLSV
NEHQRQLVIEKLQRELRILKGRTVALWGLAFKPHTDDIRCAPALAVAEHLLNLGCRVVAHDPVVTAAQVQGQLPDLQVAG
SALEAVQGADALLVMTEWPEYTRVNLGVVAAGLRQPVVIDARNCLDPQQVVQAGMRYSGVGR

Sequences:

>Translated_462_residues
MKVGVIGTGYVGLVTGACLATIGHHVVCMDNNTAKVEGLRQGVMPIYEPGLDALVAAAVATGQLQFTTEMAETVRPSDVV
FITVGTPSRADGSPDLSAVRAVARAIGAHLDGRFRVVVNKSTVPVGSGNWVRMLVEDGANLAAATAGSSHYTGNGLAVLS
PGEPPNFSVASNPEFLREGSAVWDTFNPDRIVIGAEDVKAIAVMRKLYAYWLAPEQADREPVPMVVTDLASAEMIKYAAN
AFLATKISFINEIANICERVGADVTRIAEAIGLDKRIGRSFLNAGAGWGGSCFPKDVSALVSTAAEYGHDCELLKATLSV
NEHQRQLVIEKLQRELRILKGRTVALWGLAFKPHTDDIRCAPALAVAEHLLNLGCRVVAHDPVVTAAQVQGQLPDLQVAG
SALEAVQGADALLVMTEWPEYTRVNLGVVAAGLRQPVVIDARNCLDPQQVVQAGMRYSGVGR
>Mature_462_residues
MKVGVIGTGYVGLVTGACLATIGHHVVCMDNNTAKVEGLRQGVMPIYEPGLDALVAAAVATGQLQFTTEMAETVRPSDVV
FITVGTPSRADGSPDLSAVRAVARAIGAHLDGRFRVVVNKSTVPVGSGNWVRMLVEDGANLAAATAGSSHYTGNGLAVLS
PGEPPNFSVASNPEFLREGSAVWDTFNPDRIVIGAEDVKAIAVMRKLYAYWLAPEQADREPVPMVVTDLASAEMIKYAAN
AFLATKISFINEIANICERVGADVTRIAEAIGLDKRIGRSFLNAGAGWGGSCFPKDVSALVSTAAEYGHDCELLKATLSV
NEHQRQLVIEKLQRELRILKGRTVALWGLAFKPHTDDIRCAPALAVAEHLLNLGCRVVAHDPVVTAAQVQGQLPDLQVAG
SALEAVQGADALLVMTEWPEYTRVNLGVVAAGLRQPVVIDARNCLDPQQVVQAGMRYSGVGR

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=482, Percent_Identity=31.9502074688797, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI296040438, Length=379, Percent_Identity=32.1899736147757, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI296040443, Length=306, Percent_Identity=34.3137254901961, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1788340, Length=385, Percent_Identity=27.012987012987, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI48994968, Length=458, Percent_Identity=28.3842794759825, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=492, Percent_Identity=33.130081300813, Blast_Score=250, Evalue=9e-67,
Organism=Drosophila melanogaster, GI17136908, Length=499, Percent_Identity=31.4629258517034, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48934; Mature: 48934

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGVIGTGYVGLVTGACLATIGHHVVCMDNNTAKVEGLRQGVMPIYEPGLDALVAAAVA
CEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCHHCCCHHHHHHHHHH
TGQLQFTTEMAETVRPSDVVFITVGTPSRADGSPDLSAVRAVARAIGAHLDGRFRVVVNK
CCCEEEHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEC
STVPVGSGNWVRMLVEDGANLAAATAGSSHYTGNGLAVLSPGEPPNFSVASNPEFLREGS
CCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCC
AVWDTFNPDRIVIGAEDVKAIAVMRKLYAYWLAPEQADREPVPMVVTDLASAEMIKYAAN
CEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AFLATKISFINEIANICERVGADVTRIAEAIGLDKRIGRSFLNAGAGWGGSCFPKDVSAL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
VSTAAEYGHDCELLKATLSVNEHQRQLVIEKLQRELRILKGRTVALWGLAFKPHTDDIRC
HHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCH
APALAVAEHLLNLGCRVVAHDPVVTAAQVQGQLPDLQVAGSALEAVQGADALLVMTEWPE
HHHHHHHHHHHHCCCEEEECCCCEEHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCC
YTRVNLGVVAAGLRQPVVIDARNCLDPQQVVQAGMRYSGVGR
CCEEEHHHEECCCCCCEEEECHHCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKVGVIGTGYVGLVTGACLATIGHHVVCMDNNTAKVEGLRQGVMPIYEPGLDALVAAAVA
CEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCHHCCCHHHHHHHHHH
TGQLQFTTEMAETVRPSDVVFITVGTPSRADGSPDLSAVRAVARAIGAHLDGRFRVVVNK
CCCEEEHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEC
STVPVGSGNWVRMLVEDGANLAAATAGSSHYTGNGLAVLSPGEPPNFSVASNPEFLREGS
CCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCC
AVWDTFNPDRIVIGAEDVKAIAVMRKLYAYWLAPEQADREPVPMVVTDLASAEMIKYAAN
CEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AFLATKISFINEIANICERVGADVTRIAEAIGLDKRIGRSFLNAGAGWGGSCFPKDVSAL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
VSTAAEYGHDCELLKATLSVNEHQRQLVIEKLQRELRILKGRTVALWGLAFKPHTDDIRC
HHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCH
APALAVAEHLLNLGCRVVAHDPVVTAAQVQGQLPDLQVAGSALEAVQGADALLVMTEWPE
HHHHHHHHHHHHCCCEEEECCCCEEHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCC
YTRVNLGVVAAGLRQPVVIDARNCLDPQQVVQAGMRYSGVGR
CCEEEHHHEECCCCCCEEEECHHCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]