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The map label for this gene is coaX

Identifier: 37522563

GI number: 37522563

Start: 3194005

End: 3194694

Strand: Direct

Name: coaX

Synonym: glr2994

Alternate gene names: 37522563

Gene position: 3194005-3194694 (Clockwise)

Preceding gene: 37522562

Following gene: 37522568

Centisome position: 68.56

GC content: 64.2

Gene sequence:

>690_bases
GTGTGGCTTGCAGTCAATATCGGCAACAGCCGCCAGCACTGGGGCTGGTTCACCGGAACAAAGCTGGTGCGGACGCTGGA
TTTTCCGCTCACTCACTGGGACGCGCAGGCTCCAGATGCGGCCGAGCAAATCGTAGTCGCCTCGGTAACGACCACCCATC
TGGAGCGCTGGCGCACCTTGCCCCATGCCCGTATCTTGAACCTTGCGGATGTGCCCCTATCCGGTACGTATCCCACCCTC
GGAATCGACCGGGCACTGAATTTGATCGCCGCCGCCGACGCTTACGGTTGCCCGGCCCTGGTGACTGACTTCGGAACCGC
CATCACCCTGAGTGCGGTCGATGAGTTCGGCCGCTTTTGCGGCGGGGCCATCCTGCCGGGGCTGGGCACGCAGTTGCGCG
CCCTGGAACATTTCACCGCCGCCTTACCGGCGGTGGACTTGCCCGAACCTTGGCCGCCGCTATTGGCCCGCACCACCCAA
GCAGCAATTCAAAGCGGTGTGGTGCGGGTGACCCTCGCAGGTCTTGCGCAATTTCTCGAATCCTGGAAGCGGCAGTATCC
GGGCGGCATAAGCGTAGCCACCGGCGGCGACAGCGAGCGCGTCCACCGGTGGCTACCGGACCTATTCGATGTGCAGGACA
CCCATCTCACCTTGTGGGGGATCTGCGTGGCCGCCCGGGGTGCCGATTAG

Upstream 100 bases:

>100_bases
AACCGCAAAGCCCGGCCAAGCAATAAACTCGCCGACCGACTCGATCCGACGGTGCGCGACAAACTTGCCCGTTGGCGCTT
CGGCGAATAGGACGGCCGCC

Downstream 100 bases:

>100_bases
ATGGCGGCAAAGCCGCTAAGGCTTCTCCACTTCCTTCTTCACTTCGCTGGTCTTTTCCCTGGTTTCTTTGCCCATTTCGG
AGCGCTGGGTCTTGGCACGC

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-III; Pantothenic acid kinase

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MWLAVNIGNSRQHWGWFTGTKLVRTLDFPLTHWDAQAPDAAEQIVVASVTTTHLERWRTLPHARILNLADVPLSGTYPTL
GIDRALNLIAAADAYGCPALVTDFGTAITLSAVDEFGRFCGGAILPGLGTQLRALEHFTAALPAVDLPEPWPPLLARTTQ
AAIQSGVVRVTLAGLAQFLESWKRQYPGGISVATGGDSERVHRWLPDLFDVQDTHLTLWGICVAARGAD

Sequences:

>Translated_229_residues
MWLAVNIGNSRQHWGWFTGTKLVRTLDFPLTHWDAQAPDAAEQIVVASVTTTHLERWRTLPHARILNLADVPLSGTYPTL
GIDRALNLIAAADAYGCPALVTDFGTAITLSAVDEFGRFCGGAILPGLGTQLRALEHFTAALPAVDLPEPWPPLLARTTQ
AAIQSGVVRVTLAGLAQFLESWKRQYPGGISVATGGDSERVHRWLPDLFDVQDTHLTLWGICVAARGAD
>Mature_229_residues
MWLAVNIGNSRQHWGWFTGTKLVRTLDFPLTHWDAQAPDAAEQIVVASVTTTHLERWRTLPHARILNLADVPLSGTYPTL
GIDRALNLIAAADAYGCPALVTDFGTAITLSAVDEFGRFCGGAILPGLGTQLRALEHFTAALPAVDLPEPWPPLLARTTQ
AAIQSGVVRVTLAGLAQFLESWKRQYPGGISVATGGDSERVHRWLPDLFDVQDTHLTLWGICVAARGAD

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG1521

COG function: function code K; Putative transcriptional regulator, homolog of Bvg accessory factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type III pantothenate kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAX_GLOVI (Q7NCI5)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925940.1
- ProteinModelPortal:   Q7NCI5
- SMR:   Q7NCI5
- GeneID:   2601395
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr2994
- NMPDR:   fig|251221.1.peg.2994
- HOGENOM:   HBG634537
- OMA:   NYLQALY
- ProtClustDB:   PRK13331
- BioCyc:   GVIO251221:GLR2994-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_01274
- InterPro:   IPR004619
- TIGRFAMs:   TIGR00671

Pfam domain/function: PF03309 Bvg_acc_factor

EC number: =2.7.1.33

Molecular weight: Translated: 24781; Mature: 24781

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: ACT_SITE 83-83 BINDING 77-77 BINDING 106-106 BINDING 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWLAVNIGNSRQHWGWFTGTKLVRTLDFPLTHWDAQAPDAAEQIVVASVTTTHLERWRTL
CEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHEEEEHHHHHHHHHHHCC
PHARILNLADVPLSGTYPTLGIDRALNLIAAADAYGCPALVTDFGTAITLSAVDEFGRFC
CHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCEEEHHHHHHHHHHH
GGAILPGLGTQLRALEHFTAALPAVDLPEPWPPLLARTTQAAIQSGVVRVTLAGLAQFLE
CCHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SWKRQYPGGISVATGGDSERVHRWLPDLFDVQDTHLTLWGICVAARGAD
HHHHHCCCCEEEECCCCHHHHHHHCHHHHCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MWLAVNIGNSRQHWGWFTGTKLVRTLDFPLTHWDAQAPDAAEQIVVASVTTTHLERWRTL
CEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHEEEEHHHHHHHHHHHCC
PHARILNLADVPLSGTYPTLGIDRALNLIAAADAYGCPALVTDFGTAITLSAVDEFGRFC
CHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCEEEHHHHHHHHHHH
GGAILPGLGTQLRALEHFTAALPAVDLPEPWPPLLARTTQAAIQSGVVRVTLAGLAQFLE
CCHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SWKRQYPGGISVATGGDSERVHRWLPDLFDVQDTHLTLWGICVAARGAD
HHHHHCCCCEEEECCCCHHHHHHHCHHHHCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292