Click here to switch to the map view.

The map label for this gene is gmk

Identifier: 37521190

GI number: 37521190

Start: 1736515

End: 1737132

Strand: Reverse

Name: gmk

Synonym: gll1621

Alternate gene names: 37521190

Gene position: 1737132-1736515 (Counterclockwise)

Preceding gene: 37521194

Following gene: 37521189

Centisome position: 37.29

GC content: 63.92

Gene sequence:

>618_bases
ATGCCATTTTATCGGCGATCCGCCGGATCGCCTGCAGGGCATCCCTTGAGTAGGTTGCTGGTGCTCAGCGGCCCGAGCGG
CGTCGGCAAAGACACGATCTTGCGGGAAGTGCGCGAGCGTCACCCGGGGCTCTATGTCTCGGTGTCGGCCACCACCCGCC
CGCCGCGCCCCGGCGAGGTCGACGGCAGGGACTATCGCTTTTTGAGCGCCGCCGAATTTGAAGAATGGATCGCCACGGAT
GATCTGTTGGAGTGGGCCTGCTACGTCGGCAATTACTACGGCACTCCCAAGACTCCGGTGCTCGAACGGCTGGCAGTGGG
CGAGCCGGTGGTCCTCGAAATCGACGTGCAAGGGGCGCTGCAGGTCAAAAACAACTTTCCGGCGGCTATGCTGGTATTCA
TTCGCCCGCCTTCGCTGGAGGTGCTGGCGGAGCGCCTGCGCTCCCGCGGCACCGATGCGCCCGAGGCGATCGAGCGCCGT
CTGGCGCGCGCCCGTGAAGAACTGGCCCTAGCCGACCGCTTCGATCACCAGGTGGTCAACGACAAACTGGCGGCGGCCGT
CGAAGCAGTAGAACGTCTGTTGTTTGAGGAAATACCCGATGAACCAGCCGGTGGTTGA

Upstream 100 bases:

>100_bases
CACCCACCGCCGGGGGGCGCGTTACGATGAGATACGGGAAATGCTGTACCTGCTTTTATGGACGTCCGGCCCATTGGATT
GGAACGCTGCGCATCAGGCC

Downstream 100 bases:

>100_bases
AACCGCAGAGTTGATGCGCCGCGTCGAGCAACTGGTCGACGCCGCCGCCAACCGCTATCGCATCACCGTCCAGGTGGCCA
ACCGCGCCAAGCGCCGCCGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MPFYRRSAGSPAGHPLSRLLVLSGPSGVGKDTILREVRERHPGLYVSVSATTRPPRPGEVDGRDYRFLSAAEFEEWIATD
DLLEWACYVGNYYGTPKTPVLERLAVGEPVVLEIDVQGALQVKNNFPAAMLVFIRPPSLEVLAERLRSRGTDAPEAIERR
LARAREELALADRFDHQVVNDKLAAAVEAVERLLFEEIPDEPAGG

Sequences:

>Translated_205_residues
MPFYRRSAGSPAGHPLSRLLVLSGPSGVGKDTILREVRERHPGLYVSVSATTRPPRPGEVDGRDYRFLSAAEFEEWIATD
DLLEWACYVGNYYGTPKTPVLERLAVGEPVVLEIDVQGALQVKNNFPAAMLVFIRPPSLEVLAERLRSRGTDAPEAIERR
LARAREELALADRFDHQVVNDKLAAAVEAVERLLFEEIPDEPAGG
>Mature_204_residues
PFYRRSAGSPAGHPLSRLLVLSGPSGVGKDTILREVRERHPGLYVSVSATTRPPRPGEVDGRDYRFLSAAEFEEWIATDD
LLEWACYVGNYYGTPKTPVLERLAVGEPVVLEIDVQGALQVKNNFPAAMLVFIRPPSLEVLAERLRSRGTDAPEAIERRL
ARAREELALADRFDHQVVNDKLAAAVEAVERLLFEEIPDEPAGG

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=185, Percent_Identity=40, Blast_Score=133, Evalue=9e-32,
Organism=Homo sapiens, GI226874833, Length=185, Percent_Identity=40, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI4504221, Length=185, Percent_Identity=40, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI14780902, Length=180, Percent_Identity=28.8888888888889, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=30.2857142857143, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=30.2857142857143, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI262118259, Length=165, Percent_Identity=32.1212121212121, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=30.2857142857143, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI38570142, Length=188, Percent_Identity=30.3191489361702, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI21361598, Length=192, Percent_Identity=30.2083333333333, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1790080, Length=179, Percent_Identity=42.4581005586592, Blast_Score=140, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17508835, Length=201, Percent_Identity=40.2985074626866, Blast_Score=140, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI193203132, Length=186, Percent_Identity=41.3978494623656, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71988041, Length=188, Percent_Identity=27.1276595744681, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=188, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=187, Percent_Identity=42.7807486631016, Blast_Score=150, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21356141, Length=195, Percent_Identity=36.9230769230769, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161078487, Length=193, Percent_Identity=27.979274611399, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24648808, Length=193, Percent_Identity=27.979274611399, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161078485, Length=193, Percent_Identity=27.979274611399, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24648810, Length=193, Percent_Identity=27.979274611399, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281362230, Length=193, Percent_Identity=27.979274611399, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281362232, Length=193, Percent_Identity=27.979274611399, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221330162, Length=193, Percent_Identity=30.0518134715026, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI221330166, Length=193, Percent_Identity=30.0518134715026, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_GLOVI (Q7NK59)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924567.1
- ProteinModelPortal:   Q7NK59
- SMR:   Q7NK59
- GeneID:   2598494
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll1621
- NMPDR:   fig|251221.1.peg.1621
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- BioCyc:   GVIO251221:GLL1621-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 22673; Mature: 22542

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFYRRSAGSPAGHPLSRLLVLSGPSGVGKDTILREVRERHPGLYVSVSATTRPPRPGEV
CCCCCCCCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
DGRDYRFLSAAEFEEWIATDDLLEWACYVGNYYGTPKTPVLERLAVGEPVVLEIDVQGAL
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCEE
QVKNNFPAAMLVFIRPPSLEVLAERLRSRGTDAPEAIERRLARAREELALADRFDHQVVN
EECCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKLAAAVEAVERLLFEEIPDEPAGG
HHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PFYRRSAGSPAGHPLSRLLVLSGPSGVGKDTILREVRERHPGLYVSVSATTRPPRPGEV
CCCCCCCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
DGRDYRFLSAAEFEEWIATDDLLEWACYVGNYYGTPKTPVLERLAVGEPVVLEIDVQGAL
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCEE
QVKNNFPAAMLVFIRPPSLEVLAERLRSRGTDAPEAIERRLARAREELALADRFDHQVVN
EECCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKLAAAVEAVERLLFEEIPDEPAGG
HHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292