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The map label for this gene is trxA [H]

Identifier: 37520449

GI number: 37520449

Start: 931248

End: 931580

Strand: Reverse

Name: trxA [H]

Synonym: gll0880

Alternate gene names: 37520449

Gene position: 931580-931248 (Counterclockwise)

Preceding gene: 37520450

Following gene: 37520448

Centisome position: 20.0

GC content: 56.76

Gene sequence:

>333_bases
ATGTCAGCTGCAGTGCCGGTTGGTGATTCGAACTTCAAAACCGAAGTTCTCGACAGCGAATTGCCAGTGCTGGTTGATTT
CTGGGCTCCCTGGTGCGGGCCGTGCCGCATGGTGGCGCCGGTGGTCGACGAGATTGCCCAGCAGTACAGTGGCAAGCTCA
AGGTGGTCAAGGTCAACACCGACGAAAATCCCCAGGTGGCAAGCCAGTACGGCATCCGCAGCATTCCGACGCTGATGGTT
TTTAAGTCCGGCTCCAAGGTGGATATGGTCGTCGGTGCCGTTCCGAAGACGACGCTGGCCACCACCCTCGAAAAGCATAT
CGATATCAAATAG

Upstream 100 bases:

>100_bases
GCGGTTTCTTTGTGCCGGGGCCTTGATCCCCGCCGTAGGCGCGGGCCGAAGGCCCATGGTACACTGAGGAAAAACCCTTG
TATCAGGAGCACCATTAGAT

Downstream 100 bases:

>100_bases
TGCAGGTGTGCTTTGACCTCGATTGCGGTTGATCCCCACAGCGAGTGGCAACTATCGACCGGGTCCACTTCCCGGGTCGG
CGTCACCGATACCACCTTTC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MSAAVPVGDSNFKTEVLDSELPVLVDFWAPWCGPCRMVAPVVDEIAQQYSGKLKVVKVNTDENPQVASQYGIRSIPTLMV
FKSGSKVDMVVGAVPKTTLATTLEKHIDIK

Sequences:

>Translated_110_residues
MSAAVPVGDSNFKTEVLDSELPVLVDFWAPWCGPCRMVAPVVDEIAQQYSGKLKVVKVNTDENPQVASQYGIRSIPTLMV
FKSGSKVDMVVGAVPKTTLATTLEKHIDIK
>Mature_109_residues
SAAVPVGDSNFKTEVLDSELPVLVDFWAPWCGPCRMVAPVVDEIAQQYSGKLKVVKVNTDENPQVASQYGIRSIPTLMVF
KSGSKVDMVVGAVPKTTLATTLEKHIDIK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=36.0824742268041, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI5031973, Length=109, Percent_Identity=35.7798165137615, Blast_Score=73, Evalue=5e-14,
Organism=Homo sapiens, GI50592994, Length=82, Percent_Identity=37.8048780487805, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI21361657, Length=107, Percent_Identity=29.9065420560748, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=49.5145631067961, Blast_Score=119, Evalue=5e-29,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=51.6129032258064, Blast_Score=117, Evalue=2e-28,
Organism=Escherichia coli, GI87081747, Length=103, Percent_Identity=32.0388349514563, Blast_Score=72, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=35.1063829787234, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17510299, Length=101, Percent_Identity=38.6138613861386, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=41.6666666666667, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=94, Percent_Identity=38.2978723404255, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=72, Percent_Identity=41.6666666666667, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=89, Percent_Identity=34.8314606741573, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=72, Percent_Identity=41.6666666666667, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=39.0804597701149, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17556044, Length=104, Percent_Identity=32.6923076923077, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=79, Percent_Identity=40.5063291139241, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=82, Percent_Identity=32.9268292682927, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=82, Percent_Identity=32.9268292682927, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=83, Percent_Identity=36.144578313253, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=40.6976744186046, Blast_Score=77, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=40.6976744186046, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=85, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=42.8571428571429, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24664269, Length=82, Percent_Identity=40.2439024390244, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=32.9896907216495, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=41.8918918918919, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=41.8918918918919, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17530795, Length=93, Percent_Identity=32.258064516129, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17647799, Length=81, Percent_Identity=44.4444444444444, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=37.6623376623377, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24658597, Length=108, Percent_Identity=32.4074074074074, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21358065, Length=83, Percent_Identity=36.144578313253, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24664525, Length=73, Percent_Identity=36.986301369863, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11934; Mature: 11803

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAVPVGDSNFKTEVLDSELPVLVDFWAPWCGPCRMVAPVVDEIAQQYSGKLKVVKVNT
CCCCCCCCCCCCEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECC
DENPQVASQYGIRSIPTLMVFKSGSKVDMVVGAVPKTTLATTLEKHIDIK
CCCCHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAAVPVGDSNFKTEVLDSELPVLVDFWAPWCGPCRMVAPVVDEIAQQYSGKLKVVKVNT
CCCCCCCCCCCEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECC
DENPQVASQYGIRSIPTLMVFKSGSKVDMVVGAVPKTTLATTLEKHIDIK
CCCCHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]