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The map label for this gene is strD [H]

Identifier: 34499681

GI number: 34499681

Start: 4559967

End: 4560665

Strand: Reverse

Name: strD [H]

Synonym: CV_4226

Alternate gene names: 34499681

Gene position: 4560665-4559967 (Counterclockwise)

Preceding gene: 34499682

Following gene: 34499680

Centisome position: 95.99

GC content: 71.96

Gene sequence:

>699_bases
ATGAAGGCAATGATATTGGCGGCCGGCCGCGGCGAGCGGATGCGGCCGCTGACCGACCATACGCCCAAGCCGCTGCTGAT
GGCGGGCGGCAAGCCGCTGATCCAGTGGCATATCGAGCGCCTGGTCCACGCCGGCGTCACCGATCTGGTGATCAACCATG
CCTGGCTGGGCGAGAAGATCGAAGCGGCGCTGGGCGACGGCAGCCGCTTCGGCGCGTCCATCGCCTATTCGCCGGAAGGC
TGCGCGCTGGAAACCGCCGGCGGCATCGCCACCGCGCTGCCGTTGCTGGGAGACAATCCCTTCCTGGTGCTGAACGGCGA
CGTGCTGACCGACTTCCCGGTCGCGCGGCTGGTCGAGGCGGCGGGCCGCCTGGACGGCGACGCCGCGCAGGCTCATCTGG
TATTGACGCCCAAGGCGGGCTACCAGACCGGGCGCGATCTGACGCTGCGCGCCGACGGGCGCGTGGCCGCCTGCGGGGAC
GGCGACACGCCGTACACCTTCTGCGGCCTGGCCGCCTACCACCCGGCCTTCTTCCGCGAGGTGGCGACCGGCGCGGCCAG
CCCCTTGCTGCCATGGCTGCTGGCGGCGATGGAGCGGGGCCGGATCCGCGGCGAGGTGCAGACCGGCTTGTGGCTGGACG
TCGGCACGCCGGAGCGGCTGGCCGAAGCCGGCCGCATCGCCTCCGGCTGGACGAGATGA

Upstream 100 bases:

>100_bases
ATGGCCAATGGCGGCTGACCGAGCGCAGCGCGCGCGGCTTCTGGGAGAACGAAGGCGACTTCCCGGCCGAGCGGCTGTTC
CCGAAATGAACGAGAAGAAC

Downstream 100 bases:

>100_bases
GCCGGCGCATCTTAGGCATCGATCCCGGCAGCCTGATCACCGGCTTCGGCGTCATCGACGTGGTGGGCAACCAGCGCCAT
TACGTCGCTTCCGGCGCGAT

Product: sugar-phosphate nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKAMILAAGRGERMRPLTDHTPKPLLMAGGKPLIQWHIERLVHAGVTDLVINHAWLGEKIEAALGDGSRFGASIAYSPEG
CALETAGGIATALPLLGDNPFLVLNGDVLTDFPVARLVEAAGRLDGDAAQAHLVLTPKAGYQTGRDLTLRADGRVAACGD
GDTPYTFCGLAAYHPAFFREVATGAASPLLPWLLAAMERGRIRGEVQTGLWLDVGTPERLAEAGRIASGWTR

Sequences:

>Translated_232_residues
MKAMILAAGRGERMRPLTDHTPKPLLMAGGKPLIQWHIERLVHAGVTDLVINHAWLGEKIEAALGDGSRFGASIAYSPEG
CALETAGGIATALPLLGDNPFLVLNGDVLTDFPVARLVEAAGRLDGDAAQAHLVLTPKAGYQTGRDLTLRADGRVAACGD
GDTPYTFCGLAAYHPAFFREVATGAASPLLPWLLAAMERGRIRGEVQTGLWLDVGTPERLAEAGRIASGWTR
>Mature_232_residues
MKAMILAAGRGERMRPLTDHTPKPLLMAGGKPLIQWHIERLVHAGVTDLVINHAWLGEKIEAALGDGSRFGASIAYSPEG
CALETAGGIATALPLLGDNPFLVLNGDVLTDFPVARLVEAAGRLDGDAAQAHLVLTPKAGYQTGRDLTLRADGRVAACGD
GDTPYTFCGLAAYHPAFFREVATGAASPLLPWLLAAMERGRIRGEVQTGLWLDVGTPERLAEAGRIASGWTR

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=227, Percent_Identity=30.3964757709251, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI11761619, Length=227, Percent_Identity=30.3964757709251, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI133931050, Length=225, Percent_Identity=30.2222222222222, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=122, Percent_Identity=39.344262295082, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355443, Length=228, Percent_Identity=26.7543859649123, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24644084, Length=228, Percent_Identity=26.7543859649123, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24653912, Length=129, Percent_Identity=37.984496124031, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 24526; Mature: 24526

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGRGERMRPLTDHTPKPLLMAGGKPLIQWHIERLVHAGVTDLVINHAWLGEKI
CCEEEEECCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHH
EAALGDGSRFGASIAYSPEGCALETAGGIATALPLLGDNPFLVLNGDVLTDFPVARLVEA
HHHHCCCCCCCCEEEECCCCCEEECCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHH
AGRLDGDAAQAHLVLTPKAGYQTGRDLTLRADGRVAACGDGDTPYTFCGLAAYHPAFFRE
HHCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHH
VATGAASPLLPWLLAAMERGRIRGEVQTGLWLDVGTPERLAEAGRIASGWTR
HHHCCCCHHHHHHHHHHHCCCCCEEECCCEEEECCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKAMILAAGRGERMRPLTDHTPKPLLMAGGKPLIQWHIERLVHAGVTDLVINHAWLGEKI
CCEEEEECCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHH
EAALGDGSRFGASIAYSPEGCALETAGGIATALPLLGDNPFLVLNGDVLTDFPVARLVEA
HHHHCCCCCCCCEEEECCCCCEEECCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHH
AGRLDGDAAQAHLVLTPKAGYQTGRDLTLRADGRVAACGDGDTPYTFCGLAAYHPAFFRE
HHCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHH
VATGAASPLLPWLLAAMERGRIRGEVQTGLWLDVGTPERLAEAGRIASGWTR
HHHCCCCHHHHHHHHHHHCCCCCEEECCCEEEECCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]