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The map label for this gene is ddhA [H]

Identifier: 34499348

GI number: 34499348

Start: 4202006

End: 4202776

Strand: Reverse

Name: ddhA [H]

Synonym: CV_3893

Alternate gene names: 34499348

Gene position: 4202776-4202006 (Counterclockwise)

Preceding gene: 34499349

Following gene: 34499347

Centisome position: 88.46

GC content: 62.26

Gene sequence:

>771_bases
ATGAAAGCCGTGATTTTGGCTGGTGGTCTTGGCACGCGCATCAGCGAAGAGTCCCATCTTCGTCCCAAACCGATGATCGA
GATCGGCGGCAAGCCCATCATCTGGCATATCCTGAAAATCTACTCCGCACACGGCATCAATGATTTCATCATCTGCCTGG
GCTACAAGGGATATGTGATCAAGGAATACTTCGCCAACTATTTCCTCCACACTTCCGACGTCACGCTGGATCTGAGCAAC
AACCAGATGTTCGTGCACGAGCGCCATGCCGAGCCGTGGCGGGTGACCCTGGTCGACACCGGGGAAAGCACCCAGACCGG
CGGCCGGCTGGGGCGGGTGCGCAGGCATCTGGAGAACGAGCAGGACTTCTGCTTCACCTACGGCGACGGGGTCAGCGACA
TCGACATCACCGCCGCCGTCGCTTACCACCGCAGCCAGGGCGTGGAAGCCACCGTCACCGCGGTGCATCCGCCCGGCCGC
TTCGGCGCGCTGGAGATCCGCGACGAGCGCGTCGAATTCTTCAAGGAAAAGCCGCGCGGCGACGGCGGCATGATCAACGG
CGGCTTCTTCGTGCTGAACCCGTCGGTGCTGGACCTGATAGACAGCGACGACTGCGTCTGGGAATCCGAGCCGCTGGAAA
CGCTGGCCAGCCGCGGACAGCTGGCCGCTTACGAACACAGCGGTTTCTGGCAGCCGATGGACACGCTGCGCGACAAGACC
CTGCTCGAGGAGTTGTGGCAGAGCGGGGAGGCGCCGTGGAAGCTGTGGTGA

Upstream 100 bases:

>100_bases
CCCGTCCCAAAGCGGATCCAGCCTTGCGGATGTCCGATTTACATTGGAATGGATTATCGAATCCATTTAATATACGCCGG
GCGCAACAAGAGAGAGATGT

Downstream 100 bases:

>100_bases
ATCCGGCCTTCTGGCGCGGGCGCAAGGTATTCCTGACCGGCCACACTGGCTTCAAGGGCGGCTGGCTCAGCCTGTGGCTG
GCCGACATGGGGGCCGAGGT

Product: glucose-1-phosphate cytidylyltransferase

Products: NA

Alternate protein names: CDP-glucose pyrophosphorylase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MKAVILAGGLGTRISEESHLRPKPMIEIGGKPIIWHILKIYSAHGINDFIICLGYKGYVIKEYFANYFLHTSDVTLDLSN
NQMFVHERHAEPWRVTLVDTGESTQTGGRLGRVRRHLENEQDFCFTYGDGVSDIDITAAVAYHRSQGVEATVTAVHPPGR
FGALEIRDERVEFFKEKPRGDGGMINGGFFVLNPSVLDLIDSDDCVWESEPLETLASRGQLAAYEHSGFWQPMDTLRDKT
LLEELWQSGEAPWKLW

Sequences:

>Translated_256_residues
MKAVILAGGLGTRISEESHLRPKPMIEIGGKPIIWHILKIYSAHGINDFIICLGYKGYVIKEYFANYFLHTSDVTLDLSN
NQMFVHERHAEPWRVTLVDTGESTQTGGRLGRVRRHLENEQDFCFTYGDGVSDIDITAAVAYHRSQGVEATVTAVHPPGR
FGALEIRDERVEFFKEKPRGDGGMINGGFFVLNPSVLDLIDSDDCVWESEPLETLASRGQLAAYEHSGFWQPMDTLRDKT
LLEELWQSGEAPWKLW
>Mature_256_residues
MKAVILAGGLGTRISEESHLRPKPMIEIGGKPIIWHILKIYSAHGINDFIICLGYKGYVIKEYFANYFLHTSDVTLDLSN
NQMFVHERHAEPWRVTLVDTGESTQTGGRLGRVRRHLENEQDFCFTYGDGVSDIDITAAVAYHRSQGVEATVTAVHPPGR
FGALEIRDERVEFFKEKPRGDGGMINGGFFVLNPSVLDLIDSDDCVWESEPLETLASRGQLAAYEHSGFWQPMDTLRDKT
LLEELWQSGEAPWKLW

Specific function: Involved in the biosynthesis of the tyvelose, a 3,6- dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate. This enzyme can utilize either CTP or UTP as the nucle

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate cytidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=258, Percent_Identity=30.6201550387597, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI11761619, Length=258, Percent_Identity=30.6201550387597, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI133931050, Length=253, Percent_Identity=28.0632411067194, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=26.4822134387352, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355443, Length=265, Percent_Identity=27.5471698113208, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24644084, Length=265, Percent_Identity=27.5471698113208, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013446
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.33 [H]

Molecular weight: Translated: 28911; Mature: 28911

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVILAGGLGTRISEESHLRPKPMIEIGGKPIIWHILKIYSAHGINDFIICLGYKGYVI
CCEEEEECCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCHH
KEYFANYFLHTSDVTLDLSNNQMFVHERHAEPWRVTLVDTGESTQTGGRLGRVRRHLENE
HHHHHHHEEEECCEEEEECCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCC
QDFCFTYGDGVSDIDITAAVAYHRSQGVEATVTAVHPPGRFGALEIRDERVEFFKEKPRG
CCEEEEECCCCCCCCCEEEEEEHHCCCCEEEEEEECCCCCCCEEEEEHHHHHHHHHCCCC
DGGMINGGFFVLNPSVLDLIDSDDCVWESEPLETLASRGQLAAYEHSGFWQPMDTLRDKT
CCCEEECCEEEECCHHEEEECCCCCEECCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHH
LLEELWQSGEAPWKLW
HHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKAVILAGGLGTRISEESHLRPKPMIEIGGKPIIWHILKIYSAHGINDFIICLGYKGYVI
CCEEEEECCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCHH
KEYFANYFLHTSDVTLDLSNNQMFVHERHAEPWRVTLVDTGESTQTGGRLGRVRRHLENE
HHHHHHHEEEECCEEEEECCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCC
QDFCFTYGDGVSDIDITAAVAYHRSQGVEATVTAVHPPGRFGALEIRDERVEFFKEKPRG
CCEEEEECCCCCCCCCEEEEEEHHCCCCEEEEEEECCCCCCCEEEEEHHHHHHHHHCCCC
DGGMINGGFFVLNPSVLDLIDSDDCVWESEPLETLASRGQLAAYEHSGFWQPMDTLRDKT
CCCEEECCEEEECCHHEEEECCCCCEECCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHH
LLEELWQSGEAPWKLW
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]