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The map label for this gene is mtnP [H]

Identifier: 34499349

GI number: 34499349

Start: 4203047

End: 4203772

Strand: Reverse

Name: mtnP [H]

Synonym: CV_3894

Alternate gene names: 34499349

Gene position: 4203772-4203047 (Counterclockwise)

Preceding gene: 34499355

Following gene: 34499348

Centisome position: 88.48

GC content: 67.22

Gene sequence:

>726_bases
ATGGCAATCATCGGCGGCAGCGGCCTGGCACAGCTGCCTGTACTGGACGTCACGCATCGCCAGGTGGTGCGCACGCCTTA
CGGCGATCCTTCCTGCGCGCTGACCTTCGGCAAGCTGTCCGGCCAGAACGTGGTGTTCATCGCCCGCCACGGTTACGGCC
ATTCGCTGGCGCCGCACGAGATCAATTACCGCGCCAACCTGTGGGCGCTGCACAACCAGGGCGTGAAGGGCGTGATCGCC
ATCGGCACGGTGGGCGGCATCCGCCCCGACATGGCGCCGGGACGCCTGGTCGTGCCTCACGACATCATCGACTACAGCTG
GGGACGCAAGCATACCTATTTCGAAGGGCCGGAGCGGCCGGTGGTGCACGCCGAGTTCACCACCCCGTATGACGCGGACC
TGCGCCGGCGGCTGCGCGAGGCGATCAAGTCCACCGGCATCAGCGGGGTGCACGATGGCGTGTACGCCTGCACCCAGGGA
CCGAGGCTGGAGAGCGCGGCGGAGATTCTCAAGCTGGAGCGCGACGGCGCGGACATCGTCGGCATGACCGGCATGCCGGA
GGCCGCGCTGGCCCGTGAGCTGGAGCTGCCTTACGCCCACTTGTGCCTGGTCAGCAACTGGGCAGCCGGCAAGGGAAAGC
AAGGCAAGGTCGAGTTCGACCCGGCGGTGGCCGCCAAGAGCGTGCAGGACCTGATGGATACTCTGCAGGCCTGCTTCGGA
AGCTGA

Upstream 100 bases:

>100_bases
AATCAGATGGCGGGAACAAGGGGGCGGGGAGACCGCCGTGCCCGTCCGGAACGTTCCGGACGGCGTCCGCGCAGGAAACA
CGCAAGGGGAAACGAATATG

Downstream 100 bases:

>100_bases
GCGCCGGGCGCCCGCCCGGGGCGGGGCGAGCCGAATGGGGCGAGATTGCCGCGGCCGGCTCAAGTGCTCCGCCCTTCGCG
CCGATAAAACCGCAAAGGAC

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MAIIGGSGLAQLPVLDVTHRQVVRTPYGDPSCALTFGKLSGQNVVFIARHGYGHSLAPHEINYRANLWALHNQGVKGVIA
IGTVGGIRPDMAPGRLVVPHDIIDYSWGRKHTYFEGPERPVVHAEFTTPYDADLRRRLREAIKSTGISGVHDGVYACTQG
PRLESAAEILKLERDGADIVGMTGMPEAALARELELPYAHLCLVSNWAAGKGKQGKVEFDPAVAAKSVQDLMDTLQACFG
S

Sequences:

>Translated_241_residues
MAIIGGSGLAQLPVLDVTHRQVVRTPYGDPSCALTFGKLSGQNVVFIARHGYGHSLAPHEINYRANLWALHNQGVKGVIA
IGTVGGIRPDMAPGRLVVPHDIIDYSWGRKHTYFEGPERPVVHAEFTTPYDADLRRRLREAIKSTGISGVHDGVYACTQG
PRLESAAEILKLERDGADIVGMTGMPEAALARELELPYAHLCLVSNWAAGKGKQGKVEFDPAVAAKSVQDLMDTLQACFG
S
>Mature_240_residues
AIIGGSGLAQLPVLDVTHRQVVRTPYGDPSCALTFGKLSGQNVVFIARHGYGHSLAPHEINYRANLWALHNQGVKGVIAI
GTVGGIRPDMAPGRLVVPHDIIDYSWGRKHTYFEGPERPVVHAEFTTPYDADLRRRLREAIKSTGISGVHDGVYACTQGP
RLESAAEILKLERDGADIVGMTGMPEAALARELELPYAHLCLVSNWAAGKGKQGKVEFDPAVAAKSVQDLMDTLQACFGS

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=223, Percent_Identity=33.1838565022422, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1788746, Length=137, Percent_Identity=28.4671532846715, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71980569, Length=214, Percent_Identity=36.9158878504673, Blast_Score=143, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6323045, Length=237, Percent_Identity=31.2236286919831, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20130079, Length=210, Percent_Identity=36.1904761904762, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI221459247, Length=217, Percent_Identity=34.5622119815668, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24656093, Length=140, Percent_Identity=32.1428571428571, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656090, Length=140, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45552887, Length=140, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45552885, Length=140, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 25991; Mature: 25860

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIIGGSGLAQLPVLDVTHRQVVRTPYGDPSCALTFGKLSGQNVVFIARHGYGHSLAPHE
CEEECCCCCCCCCEEECCHHHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCE
INYRANLWALHNQGVKGVIAIGTVGGIRPDMAPGRLVVPHDIIDYSWGRKHTYFEGPERP
ECCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEECCHHHCCCCCCCCCCCCCCCCCC
VVHAEFTTPYDADLRRRLREAIKSTGISGVHDGVYACTQGPRLESAAEILKLERDGADIV
EEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCEE
GMTGMPEAALARELELPYAHLCLVSNWAAGKGKQGKVEFDPAVAAKSVQDLMDTLQACFG
ECCCCCHHHHHHHHCCCHHHEEEEECCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHC
S
C
>Mature Secondary Structure 
AIIGGSGLAQLPVLDVTHRQVVRTPYGDPSCALTFGKLSGQNVVFIARHGYGHSLAPHE
EEECCCCCCCCCEEECCHHHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCE
INYRANLWALHNQGVKGVIAIGTVGGIRPDMAPGRLVVPHDIIDYSWGRKHTYFEGPERP
ECCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEECCHHHCCCCCCCCCCCCCCCCCC
VVHAEFTTPYDADLRRRLREAIKSTGISGVHDGVYACTQGPRLESAAEILKLERDGADIV
EEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCEE
GMTGMPEAALARELELPYAHLCLVSNWAAGKGKQGKVEFDPAVAAKSVQDLMDTLQACFG
ECCCCCHHHHHHHHCCCHHHEEEEECCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]