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The map label for this gene is tsaA [H]

Identifier: 34499194

GI number: 34499194

Start: 4037789

End: 4038403

Strand: Reverse

Name: tsaA [H]

Synonym: CV_3739

Alternate gene names: 34499194

Gene position: 4038403-4037789 (Counterclockwise)

Preceding gene: 34499195

Following gene: 34499193

Centisome position: 85.0

GC content: 61.63

Gene sequence:

>615_bases
ATGGCCGTACTCGTTGGCAAGCAAGCCCCGTTCTTCGCTGGTGAAAAGACTTTCTCCGCCGTGCTGGGCAATGGCGAGAT
CGTAGACAACTACTCCTTCAAGCAAGCCACCGCCGGCAAGTACGCCGTGGTGTTCTTCTACCCGCTGGACTTCACCTTCG
TCTGCCCGTCCGAACTGATCGCCTTCGACCACCGCCTGGCCGAATTCAAGGCCAAGAACGTGGAAGTGATCGGCGTGTCC
ATCGACAGCCAGTTCACCCACGCCGCATGGCGCAACACCCCGGTGGAAAAGGGCGGCATCGGCCAAGTCGGCTACACCCT
GGTCGCAGACATCCAGCACGACCTGTGCAAGGCCTACGATGTTGAAGCCGACGGCGGCGTGGCTTTCCGCGGCTCCTTCC
TGATCGACAAGTCCGGCGTGGTGCAGCACCAAGTGGTGAACAACCTGCCGCTGGGCCGCAACGTCGACGAAATGCTGCGC
ATGGTCGACGCGCTGCAATTCACCGAAGAGCACGGCGAAGTGTGCCCGGCTGGCTGGAACAAGGGCAAGAAGGGCATGAA
GCCGTCCGCCGAAGGCGTGGCTTCCTACCTGGCCGAGAACGCCAAGGACCTGTAA

Upstream 100 bases:

>100_bases
GGGCTCGGACGCAGTGTTTTATAAAGCTCCGCAATCCACGGCGTTTTCCGATGCCCGATCAGGGAAACGTTGTCATATCA
AGACCTTTAAGGAGATCAAA

Downstream 100 bases:

>100_bases
TCCGCGACTGACCCGGATTCCGTCCCGCACCCCGCCCGCGCAAGCCGGCGGGGTGTTGTTTTATCGACCGCCGCCGTCCC
CTATAACAATAGTATTCATA

Product: peroxidase

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MAVLVGKQAPFFAGEKTFSAVLGNGEIVDNYSFKQATAGKYAVVFFYPLDFTFVCPSELIAFDHRLAEFKAKNVEVIGVS
IDSQFTHAAWRNTPVEKGGIGQVGYTLVADIQHDLCKAYDVEADGGVAFRGSFLIDKSGVVQHQVVNNLPLGRNVDEMLR
MVDALQFTEEHGEVCPAGWNKGKKGMKPSAEGVASYLAENAKDL

Sequences:

>Translated_204_residues
MAVLVGKQAPFFAGEKTFSAVLGNGEIVDNYSFKQATAGKYAVVFFYPLDFTFVCPSELIAFDHRLAEFKAKNVEVIGVS
IDSQFTHAAWRNTPVEKGGIGQVGYTLVADIQHDLCKAYDVEADGGVAFRGSFLIDKSGVVQHQVVNNLPLGRNVDEMLR
MVDALQFTEEHGEVCPAGWNKGKKGMKPSAEGVASYLAENAKDL
>Mature_203_residues
AVLVGKQAPFFAGEKTFSAVLGNGEIVDNYSFKQATAGKYAVVFFYPLDFTFVCPSELIAFDHRLAEFKAKNVEVIGVSI
DSQFTHAAWRNTPVEKGGIGQVGYTLVADIQHDLCKAYDVEADGGVAFRGSFLIDKSGVVQHQVVNNLPLGRNVDEMLRM
VDALQFTEEHGEVCPAGWNKGKKGMKPSAEGVASYLAENAKDL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=197, Percent_Identity=48.7309644670051, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI4505591, Length=201, Percent_Identity=46.7661691542289, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI32455266, Length=201, Percent_Identity=46.7661691542289, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI32455264, Length=201, Percent_Identity=46.7661691542289, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI5453549, Length=194, Percent_Identity=45.360824742268, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI32483377, Length=194, Percent_Identity=47.4226804123711, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI5802974, Length=196, Percent_Identity=46.9387755102041, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI33188454, Length=86, Percent_Identity=47.6744186046512, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1786822, Length=172, Percent_Identity=36.046511627907, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193204376, Length=202, Percent_Identity=47.029702970297, Blast_Score=183, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI32565831, Length=202, Percent_Identity=47.029702970297, Blast_Score=183, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17554494, Length=189, Percent_Identity=42.8571428571429, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25153706, Length=189, Percent_Identity=26.4550264550265, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=198, Percent_Identity=40.9090909090909, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320661, Length=198, Percent_Identity=38.3838383838384, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319407, Length=159, Percent_Identity=31.4465408805031, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656348, Length=198, Percent_Identity=50.5050505050505, Blast_Score=196, Evalue=9e-51,
Organism=Drosophila melanogaster, GI17864676, Length=198, Percent_Identity=50.5050505050505, Blast_Score=196, Evalue=9e-51,
Organism=Drosophila melanogaster, GI17738015, Length=206, Percent_Identity=44.1747572815534, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17157991, Length=181, Percent_Identity=48.0662983425414, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24641739, Length=181, Percent_Identity=48.0662983425414, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21357347, Length=160, Percent_Identity=45, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24581278, Length=192, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17975518, Length=193, Percent_Identity=28.4974093264249, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24652436, Length=193, Percent_Identity=28.4974093264249, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24652434, Length=193, Percent_Identity=28.4974093264249, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22169; Mature: 22038

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLVGKQAPFFAGEKTFSAVLGNGEIVDNYSFKQATAGKYAVVFFYPLDFTFVCPSELI
CEEEECCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEECCEEEECHHHHH
AFDHRLAEFKAKNVEVIGVSIDSQFTHAAWRNTPVEKGGIGQVGYTLVADIQHDLCKAYD
HHHHHHHHHCCCCEEEEEEEECCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
VEADGGVAFRGSFLIDKSGVVQHQVVNNLPLGRNVDEMLRMVDALQFTEEHGEVCPAGWN
CCCCCCEEEECEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
KGKKGMKPSAEGVASYLAENAKDL
CCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVLVGKQAPFFAGEKTFSAVLGNGEIVDNYSFKQATAGKYAVVFFYPLDFTFVCPSELI
EEEECCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEECCEEEECHHHHH
AFDHRLAEFKAKNVEVIGVSIDSQFTHAAWRNTPVEKGGIGQVGYTLVADIQHDLCKAYD
HHHHHHHHHCCCCEEEEEEEECCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
VEADGGVAFRGSFLIDKSGVVQHQVVNNLPLGRNVDEMLRMVDALQFTEEHGEVCPAGWN
CCCCCCEEEECEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
KGKKGMKPSAEGVASYLAENAKDL
CCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]