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The map label for this gene is tmk

Identifier: 34499178

GI number: 34499178

Start: 4021506

End: 4022144

Strand: Reverse

Name: tmk

Synonym: CV_3723

Alternate gene names: 34499178

Gene position: 4022144-4021506 (Counterclockwise)

Preceding gene: 34499179

Following gene: 34499177

Centisome position: 84.66

GC content: 72.14

Gene sequence:

>639_bases
ATGAGCAGTGAGGTCCGACGCGGCCGTTTCATCACGCTGGAAGGCATAGACGGCGCCGGCAAGAGCACCCATCTTTCCTT
CATCCGCGACTGGCTGGCCCGGCATGGCGTCGACGCCGCGTTCACCCGCGAGCCGGGCGGCACGCCGCTGTCCGAGAAGA
TCCGCGACCTGCTGCTGGATCCCGGCACCGTGGCCTCGCTGGACGCCGAGGCGCTGCTGGCCTTCGCCGCGCGCCAGCAG
CACATCGCCGAGGTGATTGAGCCGGCGCTGGCCGCCGGCCGCTGGCTGGTGTCCGACCGCTTTACCGACTCCACCTACGC
CTTCCAGGGCGGCGGCCGCGGCGTGCCGTTCGAGCGCATCCGCGCGCTGGAGGACTGGGTGCAGCGCGGCCTGCAGCCGG
ACTTGACCCTGCTGTTCGACTTGCCGACCGAAGTGGCCGCCGGACGCATGGCCGGCACCCGGGTGCCGGACCGTTTCGAG
CAGGAGGCGGCCGATTTCCACCGCCGCGTGCGCGCCGCCTACCTGCGCCGCGCCGAGGAGGCGCCGCAGCGCATCGCCGT
GCTGGACGCCAGCCGCGGCATCGCCGACATCCAGGCTGACATCGTGCTCCACCTGGAACGCCTGCTGGAGCGCGGCTGA

Upstream 100 bases:

>100_bases
TGTATTTCGTCGCCCGCGGCGACGGCAGCTCCCAGTTTTCCAGCACCCTGGACGAGCATAACCAGGCGGTGCGCAAATAC
ATCCTGAAGAAAGGCCAGCA

Downstream 100 bases:

>100_bases
TGCTGTACCCGTGGCAGAGCGCGGATTGGACGCGCCTTTCCGCCGAGCGCGAGCGCATGCCCGGCGCCTGGCTCTTCACC
GGCGCCGCCGGCATCGGCAA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSSEVRRGRFITLEGIDGAGKSTHLSFIRDWLARHGVDAAFTREPGGTPLSEKIRDLLLDPGTVASLDAEALLAFAARQQ
HIAEVIEPALAAGRWLVSDRFTDSTYAFQGGGRGVPFERIRALEDWVQRGLQPDLTLLFDLPTEVAAGRMAGTRVPDRFE
QEAADFHRRVRAAYLRRAEEAPQRIAVLDASRGIADIQADIVLHLERLLERG

Sequences:

>Translated_212_residues
MSSEVRRGRFITLEGIDGAGKSTHLSFIRDWLARHGVDAAFTREPGGTPLSEKIRDLLLDPGTVASLDAEALLAFAARQQ
HIAEVIEPALAAGRWLVSDRFTDSTYAFQGGGRGVPFERIRALEDWVQRGLQPDLTLLFDLPTEVAAGRMAGTRVPDRFE
QEAADFHRRVRAAYLRRAEEAPQRIAVLDASRGIADIQADIVLHLERLLERG
>Mature_211_residues
SSEVRRGRFITLEGIDGAGKSTHLSFIRDWLARHGVDAAFTREPGGTPLSEKIRDLLLDPGTVASLDAEALLAFAARQQH
IAEVIEPALAAGRWLVSDRFTDSTYAFQGGGRGVPFERIRALEDWVQRGLQPDLTLLFDLPTEVAAGRMAGTRVPDRFEQ
EAADFHRRVRAAYLRRAEEAPQRIAVLDASRGIADIQADIVLHLERLLERG

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=191, Percent_Identity=42.9319371727749, Blast_Score=140, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_CHRVO (Q7NRQ7)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903393.1
- ProteinModelPortal:   Q7NRQ7
- SMR:   Q7NRQ7
- GeneID:   2547478
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3723
- NMPDR:   fig|243365.1.peg.3723
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q7NRQ7
- ProtClustDB:   PRK00698
- BioCyc:   CVIO243365:CV_3723-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23480; Mature: 23349

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEVRRGRFITLEGIDGAGKSTHLSFIRDWLARHGVDAAFTREPGGTPLSEKIRDLLLD
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCC
PGTVASLDAEALLAFAARQQHIAEVIEPALAAGRWLVSDRFTDSTYAFQGGGRGVPFERI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEECCCCCCCCHHHH
RALEDWVQRGLQPDLTLLFDLPTEVAAGRMAGTRVPDRFEQEAADFHRRVRAAYLRRAEE
HHHHHHHHCCCCCCEEEEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
APQRIAVLDASRGIADIQADIVLHLERLLERG
HHHHEEEHCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSEVRRGRFITLEGIDGAGKSTHLSFIRDWLARHGVDAAFTREPGGTPLSEKIRDLLLD
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCC
PGTVASLDAEALLAFAARQQHIAEVIEPALAAGRWLVSDRFTDSTYAFQGGGRGVPFERI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEECCCCCCCCHHHH
RALEDWVQRGLQPDLTLLFDLPTEVAAGRMAGTRVPDRFEQEAADFHRRVRAAYLRRAEE
HHHHHHHHCCCCCCEEEEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
APQRIAVLDASRGIADIQADIVLHLERLLERG
HHHHEEEHCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782