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The map label for this gene is frdA [H]

Identifier: 34498824

GI number: 34498824

Start: 3664122

End: 3665897

Strand: Reverse

Name: frdA [H]

Synonym: CV_3369

Alternate gene names: 34498824

Gene position: 3665897-3664122 (Counterclockwise)

Preceding gene: 34498825

Following gene: 34498823

Centisome position: 77.16

GC content: 66.67

Gene sequence:

>1776_bases
GTGAAGACCTGCCAAGCAGACGTAGTGATTGTCGGCGCCGGCGGCGCCGGCCTGAGGGCGGCCATCGCCGCCGCGCAGTT
CGATCCCAAGCTCAAGATCGCCCTGGTGTCCAAGGTGTATCCGATGCGCAGCCACACGGTGGCGGCGGAGGGCGGATCGG
CAGCGGTGAAGCAGGATCATGACAGCTTCGACGCCCACTTCCACGACACCGTGGCCGGCGGCGACTGGCTGTGCGAACAG
GACGTGGTCGAGTATTTCGTCCGCCAGTGTCCGGAAGAGATGGTGCAGCTGGAGCATTGGGGCTGTCCGTGGAGCCGCAA
GGACGACGGCAGCGTCAACGTGCGCGCCTTCGGCGGCATGAAGATAGAGCGGACCTGGTTCGCCGCCGACAAGACCGGCT
TCCACATGCTGCACACGCTGTTCCAGACCTCGATCCAGTTTCCTCAGATCCAGCGTTTCGACGAATACTTCTGCGCCGAC
CTGATCGTCGAGGATGGCCAGGCGCGCGGCGTGCTGGCCATCGAGATCGCCAGCGGCGAATCCGTCTTGATCGAGGCCGG
CGCGGTGGTGATGGCCACCGGCGGCGCCGGGCGGGTGTTCCGCGAAAACACCAATGGCGGCATCGTCACCGGCGACGGCA
TGGCGCTGGCCTACCGCCACGGCGTGCCGCTCAGGGACATGGAGTTTGTCCAGTACCACCCTACTTGCATGCCGCGCACC
GGGCTGTTGTTCACCGAGGCCTGCCGCGGCGAGGGCGGCCTGTTGATCAACAAGGACGGCTACCGCTACCTGCAGGACTA
TGGACTGGGGCCGGCCGAGGACAAGCCGCGCAACAAGTTCATGGAGCTGGGCCCGCGCGACCGCCTGAGCCAGGCCTTCT
GGTACGAGCAGCAGAAGGGCCGCACCGTGCAGGGACCATGGGGTTCCGCCGTATACCTGGACCTGCGCCACCTGGGCCAT
GCCAAGCTGCGCGAGCGGCTGCCGCAAATCTGCGAACTGGCCGAGGAGTTCCTGGGCATCGATCCGGCCAAGGAACCGAT
CCCGGTGCGGCCGGCAGTGCACTACACCATGGGCGGCATCCTGGTGGACGGACATTGCGCCGCGCCCATGCCTGGCTTGT
ACGCGGCGGGCGAGTGCTCCAGCGTCGGCATCCACGGCGCCAATCGTCTCGGCTCCAATTCGCTGGCCGAGCTGTCGGTG
TTCGGCAAGGTGGCCGGCGTCGAGGCCGCGCGTTTCGCACGCGACTGCAAACCCGCCAAGCGGGAGTCGCTGCTGAAGCA
GGCGGAGGCGGTCCAGGCCCGCCTGCATGCGCTGCGGGCCAAGGACGGCACCGAGCGCATCGCCGATTTGCGTCGCGAAA
TGGCGGAAACCATGGAGGCAGGCTGCGGCATCTACCGCATGGAAGACAGCATGCGCGCCACCTGCGACAAGCTGGCCGAG
CTCAAGCAACGCTTCCGGAACGTCAATGTGGAAGATAAATCCAGCGTGTGGAACAGCGACTGGCTGCTGGCCATCGAGCT
GGGCTACCAGCTGGACGTGGCCGAGGCGATGGCGCATTCGGCGCTGCACCGCAAGGAATCGCGCGGCGCCCACCAGCGGC
TGGACGGCTTCGAGCAGCGCGACGATGCCAACTTCCTCAAGCACAGCCACGCCATTTATCAGCCGGATGCCGGGCCGCGC
ATCGAGTACGGCGCAGTGAAGATCACCACGTCCCAACCCGGCGTGCGCGCCTATGGCGCGGCGGGGGTGGCCGCAGAACA
AGGAGAACAGGCATGA

Upstream 100 bases:

>100_bases
CTCAACCACAGTTTCATGATGCCGGGCCTGATCGGGGTGGGCGTGTCCACGTTGGCGGCCTACGCATTGACACATTTTTA
TTTCTGACGAGGGGGAGTCC

Downstream 100 bases:

>100_bases
CGGACAAAACCATCCATATCGAGGTGCTGCGCTACCGGCCCGAGCAGGACAAGGAGCCGTGGCTGCAAGGCTTCGACGTG
CCGTACAGCGACGACATGTC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MKTCQADVVIVGAGGAGLRAAIAAAQFDPKLKIALVSKVYPMRSHTVAAEGGSAAVKQDHDSFDAHFHDTVAGGDWLCEQ
DVVEYFVRQCPEEMVQLEHWGCPWSRKDDGSVNVRAFGGMKIERTWFAADKTGFHMLHTLFQTSIQFPQIQRFDEYFCAD
LIVEDGQARGVLAIEIASGESVLIEAGAVVMATGGAGRVFRENTNGGIVTGDGMALAYRHGVPLRDMEFVQYHPTCMPRT
GLLFTEACRGEGGLLINKDGYRYLQDYGLGPAEDKPRNKFMELGPRDRLSQAFWYEQQKGRTVQGPWGSAVYLDLRHLGH
AKLRERLPQICELAEEFLGIDPAKEPIPVRPAVHYTMGGILVDGHCAAPMPGLYAAGECSSVGIHGANRLGSNSLAELSV
FGKVAGVEAARFARDCKPAKRESLLKQAEAVQARLHALRAKDGTERIADLRREMAETMEAGCGIYRMEDSMRATCDKLAE
LKQRFRNVNVEDKSSVWNSDWLLAIELGYQLDVAEAMAHSALHRKESRGAHQRLDGFEQRDDANFLKHSHAIYQPDAGPR
IEYGAVKITTSQPGVRAYGAAGVAAEQGEQA

Sequences:

>Translated_591_residues
MKTCQADVVIVGAGGAGLRAAIAAAQFDPKLKIALVSKVYPMRSHTVAAEGGSAAVKQDHDSFDAHFHDTVAGGDWLCEQ
DVVEYFVRQCPEEMVQLEHWGCPWSRKDDGSVNVRAFGGMKIERTWFAADKTGFHMLHTLFQTSIQFPQIQRFDEYFCAD
LIVEDGQARGVLAIEIASGESVLIEAGAVVMATGGAGRVFRENTNGGIVTGDGMALAYRHGVPLRDMEFVQYHPTCMPRT
GLLFTEACRGEGGLLINKDGYRYLQDYGLGPAEDKPRNKFMELGPRDRLSQAFWYEQQKGRTVQGPWGSAVYLDLRHLGH
AKLRERLPQICELAEEFLGIDPAKEPIPVRPAVHYTMGGILVDGHCAAPMPGLYAAGECSSVGIHGANRLGSNSLAELSV
FGKVAGVEAARFARDCKPAKRESLLKQAEAVQARLHALRAKDGTERIADLRREMAETMEAGCGIYRMEDSMRATCDKLAE
LKQRFRNVNVEDKSSVWNSDWLLAIELGYQLDVAEAMAHSALHRKESRGAHQRLDGFEQRDDANFLKHSHAIYQPDAGPR
IEYGAVKITTSQPGVRAYGAAGVAAEQGEQA
>Mature_591_residues
MKTCQADVVIVGAGGAGLRAAIAAAQFDPKLKIALVSKVYPMRSHTVAAEGGSAAVKQDHDSFDAHFHDTVAGGDWLCEQ
DVVEYFVRQCPEEMVQLEHWGCPWSRKDDGSVNVRAFGGMKIERTWFAADKTGFHMLHTLFQTSIQFPQIQRFDEYFCAD
LIVEDGQARGVLAIEIASGESVLIEAGAVVMATGGAGRVFRENTNGGIVTGDGMALAYRHGVPLRDMEFVQYHPTCMPRT
GLLFTEACRGEGGLLINKDGYRYLQDYGLGPAEDKPRNKFMELGPRDRLSQAFWYEQQKGRTVQGPWGSAVYLDLRHLGH
AKLRERLPQICELAEEFLGIDPAKEPIPVRPAVHYTMGGILVDGHCAAPMPGLYAAGECSSVGIHGANRLGSNSLAELSV
FGKVAGVEAARFARDCKPAKRESLLKQAEAVQARLHALRAKDGTERIADLRREMAETMEAGCGIYRMEDSMRATCDKLAE
LKQRFRNVNVEDKSSVWNSDWLLAIELGYQLDVAEAMAHSALHRKESRGAHQRLDGFEQRDDANFLKHSHAIYQPDAGPR
IEYGAVKITTSQPGVRAYGAAGVAAEQGEQA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=539, Percent_Identity=39.5176252319109, Blast_Score=363, Evalue=1e-100,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=67.1821305841924, Blast_Score=774, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=544, Percent_Identity=40.9926470588235, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1788928, Length=551, Percent_Identity=31.9419237749546, Blast_Score=224, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI17550100, Length=538, Percent_Identity=39.4052044609665, Blast_Score=355, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17505833, Length=535, Percent_Identity=39.0654205607477, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI71986328, Length=434, Percent_Identity=27.1889400921659, Blast_Score=105, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6322416, Length=577, Percent_Identity=38.9948006932409, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6322701, Length=577, Percent_Identity=38.474870017331, Blast_Score=365, Evalue=1e-102,
Organism=Drosophila melanogaster, GI17137288, Length=540, Percent_Identity=41.1111111111111, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24655642, Length=540, Percent_Identity=41.1111111111111, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24655647, Length=540, Percent_Identity=41.1111111111111, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24663005, Length=536, Percent_Identity=37.6865671641791, Blast_Score=327, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64839; Mature: 64839

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTCQADVVIVGAGGAGLRAAIAAAQFDPKLKIALVSKVYPMRSHTVAAEGGSAAVKQDH
CCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEHHHCCCCCCEEEECCCCCCCCCCC
DSFDAHFHDTVAGGDWLCEQDVVEYFVRQCPEEMVQLEHWGCPWSRKDDGSVNVRAFGGM
CCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEEECCE
KIERTWFAADKTGFHMLHTLFQTSIQFPQIQRFDEYFCADLIVEDGQARGVLAIEIASGE
EEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCCEEEEEEECCC
SVLIEAGAVVMATGGAGRVFRENTNGGIVTGDGMALAYRHGVPLRDMEFVQYHPTCMPRT
EEEEECCEEEEEECCCCCEEEECCCCCEEECCCEEEEEECCCCCCCCHHHEECCCCCCCC
GLLFTEACRGEGGLLINKDGYRYLQDYGLGPAEDKPRNKFMELGPRDRLSQAFWYEQQKG
CCEEEHHHCCCCCEEECCCCHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCC
RTVQGPWGSAVYLDLRHLGHAKLRERLPQICELAEEFLGIDPAKEPIPVRPAVHYTMGGI
CEECCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCE
LVDGHCAAPMPGLYAAGECSSVGIHGANRLGSNSLAELSVFGKVAGVEAARFARDCKPAK
EECCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCHHH
RESLLKQAEAVQARLHALRAKDGTERIADLRREMAETMEAGCGIYRMEDSMRATCDKLAE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHH
LKQRFRNVNVEDKSSVWNSDWLLAIELGYQLDVAEAMAHSALHRKESRGAHQRLDGFEQR
HHHHHHCCCCCCCCCCCCCCCEEEEEECCEECHHHHHHHHHHHHHHHCCHHHHHCCCCCC
DDANFLKHSHAIYQPDAGPRIEYGAVKITTSQPGVRAYGAAGVAAEQGEQA
CCHHHHHHCCCEECCCCCCCEEECEEEEECCCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKTCQADVVIVGAGGAGLRAAIAAAQFDPKLKIALVSKVYPMRSHTVAAEGGSAAVKQDH
CCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEHHHCCCCCCEEEECCCCCCCCCCC
DSFDAHFHDTVAGGDWLCEQDVVEYFVRQCPEEMVQLEHWGCPWSRKDDGSVNVRAFGGM
CCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEEECCE
KIERTWFAADKTGFHMLHTLFQTSIQFPQIQRFDEYFCADLIVEDGQARGVLAIEIASGE
EEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCCEEEEEEECCC
SVLIEAGAVVMATGGAGRVFRENTNGGIVTGDGMALAYRHGVPLRDMEFVQYHPTCMPRT
EEEEECCEEEEEECCCCCEEEECCCCCEEECCCEEEEEECCCCCCCCHHHEECCCCCCCC
GLLFTEACRGEGGLLINKDGYRYLQDYGLGPAEDKPRNKFMELGPRDRLSQAFWYEQQKG
CCEEEHHHCCCCCEEECCCCHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCC
RTVQGPWGSAVYLDLRHLGHAKLRERLPQICELAEEFLGIDPAKEPIPVRPAVHYTMGGI
CEECCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCE
LVDGHCAAPMPGLYAAGECSSVGIHGANRLGSNSLAELSVFGKVAGVEAARFARDCKPAK
EECCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCHHH
RESLLKQAEAVQARLHALRAKDGTERIADLRREMAETMEAGCGIYRMEDSMRATCDKLAE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHH
LKQRFRNVNVEDKSSVWNSDWLLAIELGYQLDVAEAMAHSALHRKESRGAHQRLDGFEQR
HHHHHHCCCCCCCCCCCCCCCEEEEEECCEECHHHHHHHHHHHHHHHCCHHHHHCCCCCC
DDANFLKHSHAIYQPDAGPRIEYGAVKITTSQPGVRAYGAAGVAAEQGEQA
CCHHHHHHCCCEECCCCCCCEEECEEEEECCCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]