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The map label for this gene is frdB [H]

Identifier: 34498823

GI number: 34498823

Start: 3663379

End: 3664125

Strand: Reverse

Name: frdB [H]

Synonym: CV_3368

Alternate gene names: 34498823

Gene position: 3664125-3663379 (Counterclockwise)

Preceding gene: 34498824

Following gene: 34498822

Centisome position: 77.12

GC content: 62.12

Gene sequence:

>747_bases
ATGACGGACAAAACCATCCATATCGAGGTGCTGCGCTACCGGCCCGAGCAGGACAAGGAGCCGTGGCTGCAAGGCTTCGA
CGTGCCGTACAGCGACGACATGTCGGTGCTGCAGGGCCTGCAATACATCCGCGATTATCTCGACGGCACGCTGGCCTTCC
GTTGGTCCTGCCGCCAGGCCATCTGCGGCAGTTGCGGCATGATGGTGGACGGCGTGCCCAAGCTCGCCTGCAAGACCTTT
CTGCGCGACTATCCGGGCAGGGTGCGCATCGAGCCCTTGAACCACTTCCCGATCGAGCGCGATCTGGTGGTGGTGCTGGA
CGACTTCATCGACAAACTCGAAAGCATCACGCCCTATATCGTGCCCAAGGAAGACAAGCCCTTGTCCGAGGGCGAGTACC
AGCAGACGCCGGCGCAGATGGACTGGTACGCCCAGTTCAGCGGCTGCATCAATTGCCTGCTGTGCTACGCCGCCTGTCCG
CAATACGGCCTGAACTCGGATTTCCTCGGCCCCGGCGCCATCGCGCTCTTGCACCGCTACAACCAGGACAGCCGCGATGG
CGCGTCCGAACAGCGCATGGCGCTGCTGGCGGCGCAGGAGGGCGTGTTCAACTGCACGGCTGTGGGTTACTGCTCGGAAG
TCTGTCCCAAGGCGGTGGACCCGGCCAATGCGGTCAACCTGAACAAGACCGAAGTGGCCAAGGACTATTTCCTGCGATTC
GTCAGACCTAAGGGAGCATGCCAATGA

Upstream 100 bases:

>100_bases
GGCCGCGCATCGAGTACGGCGCAGTGAAGATCACCACGTCCCAACCCGGCGTGCGCGCCTATGGCGCGGCGGGGGTGGCC
GCAGAACAAGGAGAACAGGC

Downstream 100 bases:

>100_bases
GCAAGCGCAAGCCCTACGTCCGGCCGATGGAAGGCTGGTGGAAGAAGAACCCCTACTTCATCGAGTACATGATCCACGAG
GGCACGGCGCTGTTCGTCGC

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTDKTIHIEVLRYRPEQDKEPWLQGFDVPYSDDMSVLQGLQYIRDYLDGTLAFRWSCRQAICGSCGMMVDGVPKLACKTF
LRDYPGRVRIEPLNHFPIERDLVVVLDDFIDKLESITPYIVPKEDKPLSEGEYQQTPAQMDWYAQFSGCINCLLCYAACP
QYGLNSDFLGPGAIALLHRYNQDSRDGASEQRMALLAAQEGVFNCTAVGYCSEVCPKAVDPANAVNLNKTEVAKDYFLRF
VRPKGACQ

Sequences:

>Translated_248_residues
MTDKTIHIEVLRYRPEQDKEPWLQGFDVPYSDDMSVLQGLQYIRDYLDGTLAFRWSCRQAICGSCGMMVDGVPKLACKTF
LRDYPGRVRIEPLNHFPIERDLVVVLDDFIDKLESITPYIVPKEDKPLSEGEYQQTPAQMDWYAQFSGCINCLLCYAACP
QYGLNSDFLGPGAIALLHRYNQDSRDGASEQRMALLAAQEGVFNCTAVGYCSEVCPKAVDPANAVNLNKTEVAKDYFLRF
VRPKGACQ
>Mature_247_residues
TDKTIHIEVLRYRPEQDKEPWLQGFDVPYSDDMSVLQGLQYIRDYLDGTLAFRWSCRQAICGSCGMMVDGVPKLACKTFL
RDYPGRVRIEPLNHFPIERDLVVVLDDFIDKLESITPYIVPKEDKPLSEGEYQQTPAQMDWYAQFSGCINCLLCYAACPQ
YGLNSDFLGPGAIALLHRYNQDSRDGASEQRMALLAAQEGVFNCTAVGYCSEVCPKAVDPANAVNLNKTEVAKDYFLRFV
RPKGACQ

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=219, Percent_Identity=33.7899543378995, Blast_Score=127, Evalue=9e-30,
Organism=Escherichia coli, GI1790596, Length=241, Percent_Identity=57.2614107883817, Blast_Score=291, Evalue=3e-80,
Organism=Escherichia coli, GI1786943, Length=231, Percent_Identity=32.9004329004329, Blast_Score=127, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17533915, Length=222, Percent_Identity=34.2342342342342, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6322987, Length=230, Percent_Identity=33.9130434782609, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24643156, Length=222, Percent_Identity=33.7837837837838, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17137106, Length=224, Percent_Identity=31.6964285714286, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 28006; Mature: 27875

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00197 2FE2S_FER_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKTIHIEVLRYRPEQDKEPWLQGFDVPYSDDMSVLQGLQYIRDYLDGTLAFRWSCRQA
CCCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHH
ICGSCGMMVDGVPKLACKTFLRDYPGRVRIEPLNHFPIERDLVVVLDDFIDKLESITPYI
HHCCCCCHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCE
VPKEDKPLSEGEYQQTPAQMDWYAQFSGCINCLLCYAACPQYGLNSDFLGPGAIALLHRY
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHC
NQDSRDGASEQRMALLAAQEGVFNCTAVGYCSEVCPKAVDPANAVNLNKTEVAKDYFLRF
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
VRPKGACQ
HCCCCCCC
>Mature Secondary Structure 
TDKTIHIEVLRYRPEQDKEPWLQGFDVPYSDDMSVLQGLQYIRDYLDGTLAFRWSCRQA
CCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHH
ICGSCGMMVDGVPKLACKTFLRDYPGRVRIEPLNHFPIERDLVVVLDDFIDKLESITPYI
HHCCCCCHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCE
VPKEDKPLSEGEYQQTPAQMDWYAQFSGCINCLLCYAACPQYGLNSDFLGPGAIALLHRY
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHC
NQDSRDGASEQRMALLAAQEGVFNCTAVGYCSEVCPKAVDPANAVNLNKTEVAKDYFLRF
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
VRPKGACQ
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]