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The map label for this gene is lpxK

Identifier: 34498801

GI number: 34498801

Start: 3643124

End: 3644143

Strand: Reverse

Name: lpxK

Synonym: CV_3346

Alternate gene names: 34498801

Gene position: 3644143-3643124 (Counterclockwise)

Preceding gene: 34498802

Following gene: 34498800

Centisome position: 76.7

GC content: 71.57

Gene sequence:

>1020_bases
ATGCGTCTGATCGAACAACACTGGTACCGGCCGCGAGGCTGGCTGACAGCCCTTCTGGCGCCGCTGGAAGGGCTGTTTGC
GCTGCTGGCCGCTGCTCGCCGGCAGGCGTTCCGCCGCGGCTGGAAAACGAGCGGGCGACTGCCGGTTCCGGTGGTGGTGA
TAGGCAACATCAATGTCGGCGGCGTCGGCAAGACGCCGCTGACGCTGGCGCTGCTGCGCGATTTCGCCGCGCGCGGCGTC
AAGGTCGGGGTGATCAGCCGCGGCTACGGCGGCAAGGCGCCGGCGCCGACCGAGGTGGGGCCGGACAGCGACCCGGCCCT
GGTCGGCGACGAGCCGCTGCTGCTGGCCGCCGCCGGCGCGCCGGTGGTGGTGGGGCGCGACCGCGTCGCCGCCGGCCGCC
ATCTGCTGGCGCGGCATCCGGACGTGGAGCTGATTCTCAGCGACGACGGCCTGCAGCATTACCGGCTGGCGCGCGATCTG
GAGATCGTCGTGCTGGACGGCAGCCGCGGCCTGGGCAGCGGCCGGCTGCTGCCCAACGGCCCGCTGCGCGAGCCGCCGTC
GCGGCTGGCGGCGGTGGATGCCGTGGTGGTCAACGGCGAGGGCGCCCAGTTGCCGTTGCCGGATGGTCTGCCGCGCTTCG
CCATGACGCTGCGCCCCGGCGCCTGCCACGCGCTGGACGACGCGTCGCGCGCGCGGGACGCGGCCGGCTTTGCCGGGCGG
AAGGTGGCGGCCTTGGCCGGCATCGGCCATCCCGAGCGGTTTTTCGACACGCTGGCGGGGCAGGGCATCGCCGTCGAGCA
ACGACTGTCCTTCCCCGATCACCACGCGTTCGTCCCCGGCGACATTCCCGCCGACGCCGACGCGGTGATCGTCACCAGCA
AGGACGCGGTCAAGCTCGCGCGCGTGATTCATGATGCGGCGCAGCGTGCTAGACTATGGGTTTTGCCGGTTCAGGCCACG
CTGGCGCCTGATCTGTGCGAATGGATACTAGCCCGCTTGAAGACGAAACATGGACGCTAA

Upstream 100 bases:

>100_bases
ACGCATCAATCGGTGATCACCGTGATGGAGGCCGCGCGCGAGGCCGGCCTGTCGCAACTGACTTTCGCCACCCAGAACCT
GAAGTGAAGCCGAAGGCCGC

Downstream 100 bases:

>100_bases
ATTTCTGGAAATCCTGGTGTGCCCGCTGTGCAAGGGCCCGCTGGTGTTCGACAAGAGCAAGGACGAGCTGATCTGCAAGG
GAGACCGCCTGGCGTTCCCG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRLIEQHWYRPRGWLTALLAPLEGLFALLAAARRQAFRRGWKTSGRLPVPVVVIGNINVGGVGKTPLTLALLRDFAARGV
KVGVISRGYGGKAPAPTEVGPDSDPALVGDEPLLLAAAGAPVVVGRDRVAAGRHLLARHPDVELILSDDGLQHYRLARDL
EIVVLDGSRGLGSGRLLPNGPLREPPSRLAAVDAVVVNGEGAQLPLPDGLPRFAMTLRPGACHALDDASRARDAAGFAGR
KVAALAGIGHPERFFDTLAGQGIAVEQRLSFPDHHAFVPGDIPADADAVIVTSKDAVKLARVIHDAAQRARLWVLPVQAT
LAPDLCEWILARLKTKHGR

Sequences:

>Translated_339_residues
MRLIEQHWYRPRGWLTALLAPLEGLFALLAAARRQAFRRGWKTSGRLPVPVVVIGNINVGGVGKTPLTLALLRDFAARGV
KVGVISRGYGGKAPAPTEVGPDSDPALVGDEPLLLAAAGAPVVVGRDRVAAGRHLLARHPDVELILSDDGLQHYRLARDL
EIVVLDGSRGLGSGRLLPNGPLREPPSRLAAVDAVVVNGEGAQLPLPDGLPRFAMTLRPGACHALDDASRARDAAGFAGR
KVAALAGIGHPERFFDTLAGQGIAVEQRLSFPDHHAFVPGDIPADADAVIVTSKDAVKLARVIHDAAQRARLWVLPVQAT
LAPDLCEWILARLKTKHGR
>Mature_339_residues
MRLIEQHWYRPRGWLTALLAPLEGLFALLAAARRQAFRRGWKTSGRLPVPVVVIGNINVGGVGKTPLTLALLRDFAARGV
KVGVISRGYGGKAPAPTEVGPDSDPALVGDEPLLLAAAGAPVVVGRDRVAAGRHLLARHPDVELILSDDGLQHYRLARDL
EIVVLDGSRGLGSGRLLPNGPLREPPSRLAAVDAVVVNGEGAQLPLPDGLPRFAMTLRPGACHALDDASRARDAAGFAGR
KVAALAGIGHPERFFDTLAGQGIAVEQRLSFPDHHAFVPGDIPADADAVIVTSKDAVKLARVIHDAAQRARLWVLPVQAT
LAPDLCEWILARLKTKHGR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=330, Percent_Identity=43.6363636363636, Blast_Score=223, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_CHRVO (Q7NSS4)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903016.1
- ProteinModelPortal:   Q7NSS4
- GeneID:   2547424
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3346
- NMPDR:   fig|243365.1.peg.3346
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- PhylomeDB:   Q7NSS4
- ProtClustDB:   PRK00652
- BioCyc:   CVIO243365:CV_3346-MONOMER
- BRENDA:   2.7.1.130
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 35998; Mature: 35998

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIEQHWYRPRGWLTALLAPLEGLFALLAAARRQAFRRGWKTSGRLPVPVVVIGNINVG
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
GVGKTPLTLALLRDFAARGVKVGVISRGYGGKAPAPTEVGPDSDPALVGDEPLLLAAAGA
CCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCEEEEECCC
PVVVGRDRVAAGRHLLARHPDVELILSDDGLQHYRLARDLEIVVLDGSRGLGSGRLLPNG
CEEECCCCHHHCCHHHHCCCCEEEEECCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCC
PLREPPSRLAAVDAVVVNGEGAQLPLPDGLPRFAMTLRPGACHALDDASRARDAAGFAGR
CCCCCHHHHEEEEEEEECCCCCCCCCCCCCCHHEEEECCCCCCHHCCHHHHHHHCCCCCC
KVAALAGIGHPERFFDTLAGQGIAVEQRLSFPDHHAFVPGDIPADADAVIVTSKDAVKLA
HHHHHHCCCCHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHH
RVIHDAAQRARLWVLPVQATLAPDLCEWILARLKTKHGR
HHHHHHHHHCEEEEEEEHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLIEQHWYRPRGWLTALLAPLEGLFALLAAARRQAFRRGWKTSGRLPVPVVVIGNINVG
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
GVGKTPLTLALLRDFAARGVKVGVISRGYGGKAPAPTEVGPDSDPALVGDEPLLLAAAGA
CCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCEEEEECCC
PVVVGRDRVAAGRHLLARHPDVELILSDDGLQHYRLARDLEIVVLDGSRGLGSGRLLPNG
CEEECCCCHHHCCHHHHCCCCEEEEECCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCC
PLREPPSRLAAVDAVVVNGEGAQLPLPDGLPRFAMTLRPGACHALDDASRARDAAGFAGR
CCCCCHHHHEEEEEEEECCCCCCCCCCCCCCHHEEEECCCCCCHHCCHHHHHHHCCCCCC
KVAALAGIGHPERFFDTLAGQGIAVEQRLSFPDHHAFVPGDIPADADAVIVTSKDAVKLA
HHHHHHCCCCHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHH
RVIHDAAQRARLWVLPVQATLAPDLCEWILARLKTKHGR
HHHHHHHHHCEEEEEEEHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782