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The map label for this gene is uvrB

Identifier: 34498607

GI number: 34498607

Start: 3436458

End: 3438470

Strand: Reverse

Name: uvrB

Synonym: CV_3152

Alternate gene names: 34498607

Gene position: 3438470-3436458 (Counterclockwise)

Preceding gene: 34498609

Following gene: 34498605

Centisome position: 72.37

GC content: 63.98

Gene sequence:

>2013_bases
ATGCTGCTCACTTTTCCCGACAGTCCGTTCCAGCTGAACCAGCCTTTTCCGCCGGCCGGCGACCAGCCCGCCGCCATCGA
GCAATTGGTGGAGGGCCTGTCCGACGGCCTGTCCTATCAGACGCTGCTGGGCGTGACCGGCTCCGGCAAGACCTACACCA
TGGCCAACGTCATCGCCCGCACCGGGCGGCCGGCCATCATCATGGCGCACAACAAGACGCTGGCCGCGCAGCTGTACAGC
GAGATGCGCGAGTTCTTCCCGCACAACGCGGTCGAATACTTCGTCTCCTACTACGACTACTACCAGCCGGAAGCCTACGT
GCCCAGCCGCGACCTGTTCATCGAGAAGGATTCCAGCATCAACGAGCACATCGAGCAGATGCGCTTGTCGGCCACCAAGT
CGATACTGGAGCGTCCCGACTGCATCATCGTGGCGACGGTGTCGGCGATCTACGGTATCGGCGACCCGTCCGACTACCAC
CAGATGATCCTGCACCTGAAGGAAGGCGAGACCACGCCGCAGCGCGACATCATCAGCCGGCTCACCACCATGCAGTACAG
CCGCAACGATCTGGATTTCGGCCGCGGCACCTTCCGCGTGCGCGGCGACGTGATCGACATCTATCCGGCGGAAAGCAGCG
ACACCGCGCTGCGCGTCAGCCTGTTCGACGACGAGGTGGAAACGCTGACGCTGTTCGACCCCTTGACCGGGACGACCAAG
CAGCGCGTCGGCCGCTACACCGTGTTCCCGTCCAGCCATTACGTGACGCCGCGCGACACCGTGCTGCGCGCCTGCGAGCA
GATCAAGGACGAGTTGCGCCACCGCATCGAGTGGTATCAGAAGGAAGGCAAGCTGGTGGAGGCGCAGCGCATCGAGCAGC
GCACCCGCTTCGATCTGGAAATGCTGTACGAGATGGGCTTCTGCAAGGGCATCGAGAACTACTCGCGCCATTTCTCCGGC
CGCGGCCCCGGCGATCCGCCGCCGACGCTGATCGACTATCTGCCGAAGAACGCGCTGATGTTCATCGACGAAAGCCACGT
CACCGTGCCGCAGGTGGGCGCGATGTACAAGGGCGACGCCGCGCGCAAGGCCAACCTGGTGGAATACGGCTTCCGCCTGC
CGTCGGCCGCCGACAACCGGCCGCTGAAGTTCCACGAGTTCGAGCAGCTGATGCCGCAGACGATCTTCGTGTCGGCGACG
CCGGCGGTGTACGAGAAGGACCACGCGGGCCAGGTGGTGGAGCAGGTGGTGAGGCCGACCGGCCTGGTGGATCCGGAGAT
CGAGATCCGTCCGGTGGCGACCCAGGTCGACGATCTGCTGTCCGAGATCCGGGAGCGGATGGCGCGCGGCGAGCGGGTGC
TGGTCACCACGCTGACCAAGCGCATGGCCGAGCAATTGGCCGACTACTACACCGAGCACGGCGTCAAGGTGCGCTATCTG
CACAGCGACATCGACACCGTCGAGCGGGTGGAGATCATCCGCGACCTGCGCCTGGGCATGTTCGACGTGCTGATCGGCAT
CAATCTGCTGCGCGAGGGCCTGGACATTCCGGAGGTGAGCCTGGTGGCTATCCTGGATGCTGATAAAGAGGGTTTCCTGC
GTAGCGAGCGCAGCCTGATCCAGACCATAGGCCGCGCCGCGCGTAACCTGCGCGGCAAGGCGCTGCTGTACGCCGACCGC
ATCACCGACTCCATGCGCAAGGCGATGGACGAAACCGAGCGCCGCCGCGCCAAGCAGATGGCGTTCAACGCCGAGCACGG
CATCGTGCCCAAGGGCGTGGAGAAGAAGATCAAGGACATCATCGACGGCGTCTACAGCGTGGAGGCCGAACGCAAGAAGC
TGGTGGACGAGGCCGCGGTGGCGATGATGGATGAGAAGACGCTGTCCAAGGAGATCAAGCGTCTGGAAAAGGAGATGATG
GAGGCGGCGCGCAATCTGGAATTCGAACGCGCGGCGCGCATCCGCGACGAGTTGAAGCAGTTGAAGGAAAAGGCCTGGCT
CAGCGATTTGTGA

Upstream 100 bases:

>100_bases
CCTTGCCGGGCGGCGCTGCGCCGGGCACCGGGAAACGGGGGGTGAGATCGGGCGGATATCGGCGTAAAATCAACCTTTTC
GCCATTGTTCCGGGTCCGCC

Downstream 100 bases:

>100_bases
GCGATGGCCCTGTCTCCCCGGCAAGCCCGCGCGTCGACCCGCGCGGGCTTGTCTTTTATCCGGACTCCAACAGCTCCGGC
GGCAGTGCGGCCATCTCGGC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MLLTFPDSPFQLNQPFPPAGDQPAAIEQLVEGLSDGLSYQTLLGVTGSGKTYTMANVIARTGRPAIIMAHNKTLAAQLYS
EMREFFPHNAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSINEHIEQMRLSATKSILERPDCIIVATVSAIYGIGDPSDYH
QMILHLKEGETTPQRDIISRLTTMQYSRNDLDFGRGTFRVRGDVIDIYPAESSDTALRVSLFDDEVETLTLFDPLTGTTK
QRVGRYTVFPSSHYVTPRDTVLRACEQIKDELRHRIEWYQKEGKLVEAQRIEQRTRFDLEMLYEMGFCKGIENYSRHFSG
RGPGDPPPTLIDYLPKNALMFIDESHVTVPQVGAMYKGDAARKANLVEYGFRLPSAADNRPLKFHEFEQLMPQTIFVSAT
PAVYEKDHAGQVVEQVVRPTGLVDPEIEIRPVATQVDDLLSEIRERMARGERVLVTTLTKRMAEQLADYYTEHGVKVRYL
HSDIDTVERVEIIRDLRLGMFDVLIGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLRGKALLYADR
ITDSMRKAMDETERRRAKQMAFNAEHGIVPKGVEKKIKDIIDGVYSVEAERKKLVDEAAVAMMDEKTLSKEIKRLEKEMM
EAARNLEFERAARIRDELKQLKEKAWLSDL

Sequences:

>Translated_670_residues
MLLTFPDSPFQLNQPFPPAGDQPAAIEQLVEGLSDGLSYQTLLGVTGSGKTYTMANVIARTGRPAIIMAHNKTLAAQLYS
EMREFFPHNAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSINEHIEQMRLSATKSILERPDCIIVATVSAIYGIGDPSDYH
QMILHLKEGETTPQRDIISRLTTMQYSRNDLDFGRGTFRVRGDVIDIYPAESSDTALRVSLFDDEVETLTLFDPLTGTTK
QRVGRYTVFPSSHYVTPRDTVLRACEQIKDELRHRIEWYQKEGKLVEAQRIEQRTRFDLEMLYEMGFCKGIENYSRHFSG
RGPGDPPPTLIDYLPKNALMFIDESHVTVPQVGAMYKGDAARKANLVEYGFRLPSAADNRPLKFHEFEQLMPQTIFVSAT
PAVYEKDHAGQVVEQVVRPTGLVDPEIEIRPVATQVDDLLSEIRERMARGERVLVTTLTKRMAEQLADYYTEHGVKVRYL
HSDIDTVERVEIIRDLRLGMFDVLIGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLRGKALLYADR
ITDSMRKAMDETERRRAKQMAFNAEHGIVPKGVEKKIKDIIDGVYSVEAERKKLVDEAAVAMMDEKTLSKEIKRLEKEMM
EAARNLEFERAARIRDELKQLKEKAWLSDL
>Mature_670_residues
MLLTFPDSPFQLNQPFPPAGDQPAAIEQLVEGLSDGLSYQTLLGVTGSGKTYTMANVIARTGRPAIIMAHNKTLAAQLYS
EMREFFPHNAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSINEHIEQMRLSATKSILERPDCIIVATVSAIYGIGDPSDYH
QMILHLKEGETTPQRDIISRLTTMQYSRNDLDFGRGTFRVRGDVIDIYPAESSDTALRVSLFDDEVETLTLFDPLTGTTK
QRVGRYTVFPSSHYVTPRDTVLRACEQIKDELRHRIEWYQKEGKLVEAQRIEQRTRFDLEMLYEMGFCKGIENYSRHFSG
RGPGDPPPTLIDYLPKNALMFIDESHVTVPQVGAMYKGDAARKANLVEYGFRLPSAADNRPLKFHEFEQLMPQTIFVSAT
PAVYEKDHAGQVVEQVVRPTGLVDPEIEIRPVATQVDDLLSEIRERMARGERVLVTTLTKRMAEQLADYYTEHGVKVRYL
HSDIDTVERVEIIRDLRLGMFDVLIGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLRGKALLYADR
ITDSMRKAMDETERRRAKQMAFNAEHGIVPKGVEKKIKDIIDGVYSVEAERKKLVDEAAVAMMDEKTLSKEIKRLEKEMM
EAARNLEFERAARIRDELKQLKEKAWLSDL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=67.0180722891566, Blast_Score=889, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_CHRVO (Q7NTA7)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902822.1
- ProteinModelPortal:   Q7NTA7
- GeneID:   2547340
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3152
- NMPDR:   fig|243365.1.peg.3152
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- PhylomeDB:   Q7NTA7
- ProtClustDB:   PRK05298
- BioCyc:   CVIO243365:CV_3152-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76439; Mature: 76439

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLTFPDSPFQLNQPFPPAGDQPAAIEQLVEGLSDGLSYQTLLGVTGSGKTYTMANVIAR
CEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHEEECCCCCEEHHHHHHHH
TGRPAIIMAHNKTLAAQLYSEMREFFPHNAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSI
CCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCH
NEHIEQMRLSATKSILERPDCIIVATVSAIYGIGDPSDYHQMILHLKEGETTPQRDIISR
HHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
LTTMQYSRNDLDFGRGTFRVRGDVIDIYPAESSDTALRVSLFDDEVETLTLFDPLTGTTK
HHHHHHCCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCCHH
QRVGRYTVFPSSHYVTPRDTVLRACEQIKDELRHRIEWYQKEGKLVEAQRIEQRTRFDLE
HHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
MLYEMGFCKGIENYSRHFSGRGPGDPPPTLIDYLPKNALMFIDESHVTVPQVGAMYKGDA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCC
ARKANLVEYGFRLPSAADNRPLKFHEFEQLMPQTIFVSATPAVYEKDHAGQVVEQVVRPT
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCHHHCCCHHHHHHHHHHCCC
GLVDPEIEIRPVATQVDDLLSEIRERMARGERVLVTTLTKRMAEQLADYYTEHGVKVRYL
CCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCCEEEEE
HSDIDTVERVEIIRDLRLGMFDVLIGINLLREGLDIPEVSLVAILDADKEGFLRSERSLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHH
QTIGRAARNLRGKALLYADRITDSMRKAMDETERRRAKQMAFNAEHGIVPKGVEKKIKDI
HHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
IDGVYSVEAERKKLVDEAAVAMMDEKTLSKEIKRLEKEMMEAARNLEFERAARIRDELKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LKEKAWLSDL
HHHHHHCCCC
>Mature Secondary Structure
MLLTFPDSPFQLNQPFPPAGDQPAAIEQLVEGLSDGLSYQTLLGVTGSGKTYTMANVIAR
CEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHEEECCCCCEEHHHHHHHH
TGRPAIIMAHNKTLAAQLYSEMREFFPHNAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSI
CCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCH
NEHIEQMRLSATKSILERPDCIIVATVSAIYGIGDPSDYHQMILHLKEGETTPQRDIISR
HHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
LTTMQYSRNDLDFGRGTFRVRGDVIDIYPAESSDTALRVSLFDDEVETLTLFDPLTGTTK
HHHHHHCCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCCHH
QRVGRYTVFPSSHYVTPRDTVLRACEQIKDELRHRIEWYQKEGKLVEAQRIEQRTRFDLE
HHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
MLYEMGFCKGIENYSRHFSGRGPGDPPPTLIDYLPKNALMFIDESHVTVPQVGAMYKGDA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCC
ARKANLVEYGFRLPSAADNRPLKFHEFEQLMPQTIFVSATPAVYEKDHAGQVVEQVVRPT
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCHHHCCCHHHHHHHHHHCCC
GLVDPEIEIRPVATQVDDLLSEIRERMARGERVLVTTLTKRMAEQLADYYTEHGVKVRYL
CCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCCEEEEE
HSDIDTVERVEIIRDLRLGMFDVLIGINLLREGLDIPEVSLVAILDADKEGFLRSERSLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHH
QTIGRAARNLRGKALLYADRITDSMRKAMDETERRRAKQMAFNAEHGIVPKGVEKKIKDI
HHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
IDGVYSVEAERKKLVDEAAVAMMDEKTLSKEIKRLEKEMMEAARNLEFERAARIRDELKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LKEKAWLSDL
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782