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The map label for this gene is lpxB

Identifier: 34497664

GI number: 34497664

Start: 2379831

End: 2380991

Strand: Direct

Name: lpxB

Synonym: CV_2209

Alternate gene names: 34497664

Gene position: 2379831-2380991 (Clockwise)

Preceding gene: 34497663

Following gene: 34497665

Centisome position: 50.09

GC content: 66.41

Gene sequence:

>1161_bases
CTGTTCAAGCGCAAGGGGGCCTTGAAGGTTGCCATGGTGGCCGGGGAGGCTTCCGGCGACCTGCTGGCCGCCCACCTGAT
GGATGCGCTGCGCGCGCACCGCAGCGACATCGAATTCGCCGGCATCGGCGGCCCGCGCATGGAAGCCCGCGGCTTCCACA
GCATGGTGCCGCAGGAGAAGCTGGCGGTGCGCGGCTACTCCGAAGTCCTGAAAAGCCTGCCGGAGCTGCTGAAGATACGC
CGCCGGCTGCGCGAGCAGCTGCTGGAGGAAAGGCCGGATGTTTTCATCGGCGTGGATGCCCCCGATTTCAACCTGGGCCT
GGAGGCCGGCTTGAAGAAGGGCGGTATTCCCACCGTGCATTACGTCAGCCCTTCGGTATGGGCGTGGCGTCCTGAGCGCG
TCCAGAAGATAGGCCGCGCGGTCAACCACGTGCTGTGCCTGTTCCCGATGGAACCGCCGCTGTACCGCCAGGCCGGCGTG
CCGGTGACTTATGTCGGCCATCCGCTGGCCAGCGAGATTCCGCTGGAGCCGGACCGGGAGGCGATGCGCGACCAACTGGG
GCTGCCGCAAGGCGTGCCGGTGTTCACCCTGATGCCGGGCAGCCGCCAGAGCGAGCTGGAATACATGGTGCCCATCTACC
TGGACACGGCCCGCCTGCTGTTGCGCCAGTATCCGGAGGCCCAATTCCTGGTGCCGTTGGCCACCCGCGCCACCATGGAC
CAGTTCGAGCAGATGCTGTACCGCTTCAAGGCGCGCGACCTTCCCATACGCAAGCTGTTCGGCCACGCGCAGATGGCGAT
GATCGCCAGCGACGTGGTGCTGGTCACCAGCGGCACGGCGACGCTGGAGGTGGCGCTGACCAAGCGGCCGATGGTGATCA
GCTACAAGCTGTCCGCCCTGACTTACCGGCTGGTCAAGCGCAAGATCAAGCTGCCCTACGTCGGTCTGCCCAATATCTTG
TGCGGCCGCTTCGTGGTGCCGGAACTGCTGCAGAAGCAGGCCACGCCGCAGAAGCTGGCCGAGGAGATGCAGCGGCTGTA
CACCGACTCCGCGGCCAGGGCCGACATGGAAAAGGCGTTCACCGAACTGCACCTGGCCTTGAAGCAGGATACGGCCACCC
GCGCCGCGCGCGCGGTGCTGGAGGTGGCGCGATGCCATTGA

Upstream 100 bases:

>100_bases
CTGGCCGAAGCGGGCGAAGGCCATGCCGAGCTGGAGCCGTTCGTGCGCTTCTTCGGACAATCGGCGCGAGGCATCATCCG
CTGAGCTTATGAGCGACCAA

Downstream 100 bases:

>100_bases
AGCTGCGGGTGGCGGGCGTGGACGAGGCGGGCCGCGGTCCGCTGGCCGGCGCCGTGTTCGCCGCCGCCGTCATCCTGGAT
CCGGCCAAACCGATCGCCGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MFKRKGALKVAMVAGEASGDLLAAHLMDALRAHRSDIEFAGIGGPRMEARGFHSMVPQEKLAVRGYSEVLKSLPELLKIR
RRLREQLLEERPDVFIGVDAPDFNLGLEAGLKKGGIPTVHYVSPSVWAWRPERVQKIGRAVNHVLCLFPMEPPLYRQAGV
PVTYVGHPLASEIPLEPDREAMRDQLGLPQGVPVFTLMPGSRQSELEYMVPIYLDTARLLLRQYPEAQFLVPLATRATMD
QFEQMLYRFKARDLPIRKLFGHAQMAMIASDVVLVTSGTATLEVALTKRPMVISYKLSALTYRLVKRKIKLPYVGLPNIL
CGRFVVPELLQKQATPQKLAEEMQRLYTDSAARADMEKAFTELHLALKQDTATRAARAVLEVARCH

Sequences:

>Translated_386_residues
MFKRKGALKVAMVAGEASGDLLAAHLMDALRAHRSDIEFAGIGGPRMEARGFHSMVPQEKLAVRGYSEVLKSLPELLKIR
RRLREQLLEERPDVFIGVDAPDFNLGLEAGLKKGGIPTVHYVSPSVWAWRPERVQKIGRAVNHVLCLFPMEPPLYRQAGV
PVTYVGHPLASEIPLEPDREAMRDQLGLPQGVPVFTLMPGSRQSELEYMVPIYLDTARLLLRQYPEAQFLVPLATRATMD
QFEQMLYRFKARDLPIRKLFGHAQMAMIASDVVLVTSGTATLEVALTKRPMVISYKLSALTYRLVKRKIKLPYVGLPNIL
CGRFVVPELLQKQATPQKLAEEMQRLYTDSAARADMEKAFTELHLALKQDTATRAARAVLEVARCH
>Mature_386_residues
MFKRKGALKVAMVAGEASGDLLAAHLMDALRAHRSDIEFAGIGGPRMEARGFHSMVPQEKLAVRGYSEVLKSLPELLKIR
RRLREQLLEERPDVFIGVDAPDFNLGLEAGLKKGGIPTVHYVSPSVWAWRPERVQKIGRAVNHVLCLFPMEPPLYRQAGV
PVTYVGHPLASEIPLEPDREAMRDQLGLPQGVPVFTLMPGSRQSELEYMVPIYLDTARLLLRQYPEAQFLVPLATRATMD
QFEQMLYRFKARDLPIRKLFGHAQMAMIASDVVLVTSGTATLEVALTKRPMVISYKLSALTYRLVKRKIKLPYVGLPNIL
CGRFVVPELLQKQATPQKLAEEMQRLYTDSAARADMEKAFTELHLALKQDTATRAARAVLEVARCH

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=377, Percent_Identity=46.1538461538462, Blast_Score=329, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_CHRVO (Q7NVY1)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901879.1
- ProteinModelPortal:   Q7NVY1
- GeneID:   2549496
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2209
- NMPDR:   fig|243365.1.peg.2209
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   Q7NVY1
- ProtClustDB:   CLSK2485471
- BioCyc:   CVIO243365:CV_2209-MONOMER
- BRENDA:   2.4.1.182
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 43315; Mature: 43315

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRKGALKVAMVAGEASGDLLAAHLMDALRAHRSDIEFAGIGGPRMEARGFHSMVPQEK
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCHHCCHHHHCCHHH
LAVRGYSEVLKSLPELLKIRRRLREQLLEERPDVFIGVDAPDFNLGLEAGLKKGGIPTVH
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHCCCCCCCCEEE
YVSPSVWAWRPERVQKIGRAVNHVLCLFPMEPPLYRQAGVPVTYVGHPLASEIPLEPDRE
EECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHCCCCEEECCCCCCCCCCCCCCHH
AMRDQLGLPQGVPVFTLMPGSRQSELEYMVPIYLDTARLLLRQYPEAQFLVPLATRATMD
HHHHHCCCCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEEHHHHHHHHH
QFEQMLYRFKARDLPIRKLFGHAQMAMIASDVVLVTSGTATLEVALTKRPMVISYKLSAL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEECCCEEEEEEECCCCEEEEEHHHHH
TYRLVKRKIKLPYVGLPNILCGRFVVPELLQKQATPQKLAEEMQRLYTDSAARADMEKAF
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TELHLALKQDTATRAARAVLEVARCH
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFKRKGALKVAMVAGEASGDLLAAHLMDALRAHRSDIEFAGIGGPRMEARGFHSMVPQEK
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCHHCCHHHHCCHHH
LAVRGYSEVLKSLPELLKIRRRLREQLLEERPDVFIGVDAPDFNLGLEAGLKKGGIPTVH
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHCCCCCCCCEEE
YVSPSVWAWRPERVQKIGRAVNHVLCLFPMEPPLYRQAGVPVTYVGHPLASEIPLEPDRE
EECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHCCCCEEECCCCCCCCCCCCCCHH
AMRDQLGLPQGVPVFTLMPGSRQSELEYMVPIYLDTARLLLRQYPEAQFLVPLATRATMD
HHHHHCCCCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEEHHHHHHHHH
QFEQMLYRFKARDLPIRKLFGHAQMAMIASDVVLVTSGTATLEVALTKRPMVISYKLSAL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEECCCEEEEEEECCCCEEEEEHHHHH
TYRLVKRKIKLPYVGLPNILCGRFVVPELLQKQATPQKLAEEMQRLYTDSAARADMEKAF
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TELHLALKQDTATRAARAVLEVARCH
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782