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The map label for this gene is crt [H]

Identifier: 34497538

GI number: 34497538

Start: 2268809

End: 2269627

Strand: Reverse

Name: crt [H]

Synonym: CV_2083

Alternate gene names: 34497538

Gene position: 2269627-2268809 (Counterclockwise)

Preceding gene: 34497539

Following gene: 34497537

Centisome position: 47.77

GC content: 66.42

Gene sequence:

>819_bases
TTGCCGGTTCAAAACAGAATTCATAAAGGCATAAATATGAATAGCTACGCCCACCTGAACGTGGAAAAACGCGGCCACAC
CGCCGTGGTGACCATAGACAACCCGCCGGCCAACACCTGGAACCGCGCCAGCCTCACCGCGCTGAAGCAGTTGGTGGCCG
ACCTCAACGCCGACCGCGACATCTACGCGCTGGTGATCACCGGCCAGGGCGAGAAATTCTTCTCCGCCGGCGCCGACCTG
AACCTGTTCGCCGATGGAGACAAGAAAGTCGCCACCGAGATGACCCTGCTGTTCGGCGAAGCCTTCGAGGCGCTGTCGGC
TTTTCGCGGCGTCAGCATCGCCGCGATCAACGGCTACGCCATGGGCGGCGGCCTGGAGTGCGCGCTGGCCTGCGACATCC
GCATCGCCGAGGAGCAGGCGCAGATGGCGCTGCCGGAAGCCGGCGTCGGCCTGCTGCCCTGCGCCGGCGGCACCCAGAAC
CTGCCGTGGCTGGTCGGCGAAGGCTGGGCCAAGCGCATGATCCTGTGCGGCGAACGCGTCAACGCCGCCACCGCCGAACG
CATCGGCCTGGTGGAACAGGTGGTGGCCAAGGGCGAGGCGCTGGCCGCTGCGCTCAAGCTGGCCGAAGGCGTGGCCAGGC
AGTCGCCGTCGTCGGTCGGCGTGTGCAAGCAGCTGGTGCAGGCCGCCCGCACCCAGCCGCCGGCCTGGAACCTGATCAAG
GAACGCGAAGCCTTCATCAAGCTGTTCGACACCCAGGACCAGGCCGAAGGCACCCGCGCCTTCCTGGAAAAGCGCGCGCC
GAACTGGAAGAACGCCTGA

Upstream 100 bases:

>100_bases
GCAAAATCCCTGATGCTGCGTTGCGCCGGCTGGCCGTACTCATATGTACTGTCTGCGCCGGCGCGCCTTGCCTCAGCCGC
TGCGCTGGATTTTTCCAGCC

Downstream 100 bases:

>100_bases
AACCCGCCCATCACCCGAACGAGGTCCCGCCATGCAAGACGTGGTGCTGTTTGACGAACTGACTACCGGCGACGGCCATC
GCATCGCCGTCGCCACCCTC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPVQNRIHKGINMNSYAHLNVEKRGHTAVVTIDNPPANTWNRASLTALKQLVADLNADRDIYALVITGQGEKFFSAGADL
NLFADGDKKVATEMTLLFGEAFEALSAFRGVSIAAINGYAMGGGLECALACDIRIAEEQAQMALPEAGVGLLPCAGGTQN
LPWLVGEGWAKRMILCGERVNAATAERIGLVEQVVAKGEALAAALKLAEGVARQSPSSVGVCKQLVQAARTQPPAWNLIK
EREAFIKLFDTQDQAEGTRAFLEKRAPNWKNA

Sequences:

>Translated_272_residues
MPVQNRIHKGINMNSYAHLNVEKRGHTAVVTIDNPPANTWNRASLTALKQLVADLNADRDIYALVITGQGEKFFSAGADL
NLFADGDKKVATEMTLLFGEAFEALSAFRGVSIAAINGYAMGGGLECALACDIRIAEEQAQMALPEAGVGLLPCAGGTQN
LPWLVGEGWAKRMILCGERVNAATAERIGLVEQVVAKGEALAAALKLAEGVARQSPSSVGVCKQLVQAARTQPPAWNLIK
EREAFIKLFDTQDQAEGTRAFLEKRAPNWKNA
>Mature_271_residues
PVQNRIHKGINMNSYAHLNVEKRGHTAVVTIDNPPANTWNRASLTALKQLVADLNADRDIYALVITGQGEKFFSAGADLN
LFADGDKKVATEMTLLFGEAFEALSAFRGVSIAAINGYAMGGGLECALACDIRIAEEQAQMALPEAGVGLLPCAGGTQNL
PWLVGEGWAKRMILCGERVNAATAERIGLVEQVVAKGEALAAALKLAEGVARQSPSSVGVCKQLVQAARTQPPAWNLIKE
REAFIKLFDTQDQAEGTRAFLEKRAPNWKNA

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=261, Percent_Identity=34.0996168582375, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI68989263, Length=201, Percent_Identity=35.8208955223881, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI20127408, Length=200, Percent_Identity=37, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4502327, Length=257, Percent_Identity=30.3501945525292, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI37594471, Length=212, Percent_Identity=27.8301886792453, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI37594469, Length=212, Percent_Identity=27.8301886792453, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI261878539, Length=109, Percent_Identity=41.2844036697248, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI31542718, Length=251, Percent_Identity=28.2868525896414, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI150378541, Length=245, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI70995211, Length=267, Percent_Identity=27.7153558052434, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI157694516, Length=170, Percent_Identity=24.7058823529412, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI213417737, Length=170, Percent_Identity=24.7058823529412, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787659, Length=258, Percent_Identity=39.5348837209302, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI221142681, Length=256, Percent_Identity=32.8125, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1788682, Length=215, Percent_Identity=35.3488372093023, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1790281, Length=193, Percent_Identity=32.6424870466321, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI87082183, Length=261, Percent_Identity=24.904214559387, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787660, Length=267, Percent_Identity=29.5880149812734, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788597, Length=250, Percent_Identity=24.8, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=257, Percent_Identity=35.0194552529183, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25145438, Length=256, Percent_Identity=34.375, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17540714, Length=192, Percent_Identity=32.8125, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17558304, Length=182, Percent_Identity=35.7142857142857, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25144276, Length=180, Percent_Identity=38.3333333333333, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17508951, Length=180, Percent_Identity=38.3333333333333, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508953, Length=180, Percent_Identity=38.3333333333333, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17560910, Length=234, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=200, Percent_Identity=30, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=238, Percent_Identity=25.6302521008403, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25141363, Length=160, Percent_Identity=31.875, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25144160, Length=190, Percent_Identity=28.4210526315789, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=190, Percent_Identity=28.4210526315789, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=213, Percent_Identity=27.2300469483568, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17535521, Length=218, Percent_Identity=25.6880733944954, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129971, Length=273, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24653477, Length=273, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24653139, Length=252, Percent_Identity=32.9365079365079, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21357171, Length=195, Percent_Identity=29.7435897435897, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650670, Length=272, Percent_Identity=27.5735294117647, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24654903, Length=192, Percent_Identity=25.5208333333333, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922422, Length=247, Percent_Identity=24.6963562753036, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583077, Length=252, Percent_Identity=30.1587301587302, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583079, Length=252, Percent_Identity=30.1587301587302, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921000, Length=252, Percent_Identity=30.1587301587302, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19920382, Length=191, Percent_Identity=29.8429319371728, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 29129; Mature: 28997

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVQNRIHKGINMNSYAHLNVEKRGHTAVVTIDNPPANTWNRASLTALKQLVADLNADRD
CCCHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCC
IYALVITGQGEKFFSAGADLNLFADGDKKVATEMTLLFGEAFEALSAFRGVSIAAINGYA
EEEEEEECCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEE
MGGGLECALACDIRIAEEQAQMALPEAGVGLLPCAGGTQNLPWLVGEGWAKRMILCGERV
ECCCCEEEEEEEEEECHHHHHHCCCCCCCEEEECCCCCCCCCEEECCHHHHHHHHCCCCC
NAATAERIGLVEQVVAKGEALAAALKLAEGVARQSPSSVGVCKQLVQAARTQPPAWNLIK
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHH
EREAFIKLFDTQDQAEGTRAFLEKRAPNWKNA
HHHHHHHEECCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PVQNRIHKGINMNSYAHLNVEKRGHTAVVTIDNPPANTWNRASLTALKQLVADLNADRD
CCHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCC
IYALVITGQGEKFFSAGADLNLFADGDKKVATEMTLLFGEAFEALSAFRGVSIAAINGYA
EEEEEEECCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEE
MGGGLECALACDIRIAEEQAQMALPEAGVGLLPCAGGTQNLPWLVGEGWAKRMILCGERV
ECCCCEEEEEEEEEECHHHHHHCCCCCCCEEEECCCCCCCCCEEECCHHHHHHHHCCCCC
NAATAERIGLVEQVVAKGEALAAALKLAEGVARQSPSSVGVCKQLVQAARTQPPAWNLIK
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHH
EREAFIKLFDTQDQAEGTRAFLEKRAPNWKNA
HHHHHHHEECCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]