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The map label for this gene is caiA [H]

Identifier: 34497539

GI number: 34497539

Start: 2269737

End: 2270897

Strand: Reverse

Name: caiA [H]

Synonym: CV_2084

Alternate gene names: 34497539

Gene position: 2270897-2269737 (Counterclockwise)

Preceding gene: 34497540

Following gene: 34497538

Centisome position: 47.8

GC content: 65.2

Gene sequence:

>1161_bases
ATGAATTTCGAACTGAACGAAGACCAGATCGCCTTCCAGCAAAGCGCCCGCGATTTCGCCGAGCATGAGCTGGCGCCGCA
CGCGGCCGAATGGGACGCCGAGTCCCTCTTCCCGCTGGACGTGATCCGCAAGAGCGGCGACATGGGCTTTCTGGGCCTGT
ACACGCCGGAAGCTTACGGCGGCCTGGGCCTGTCGCGGCTGGACTCCGCCATCGTGTTCGAGGAGCTGGCCGCCGGTTGC
ACCTCCACCGCCGCCTACCTGACCATCCACAACATGGTCAGCTGGATGATCGCCAGCTTCGGCAGCAAGCAACTAGCTGA
ACAATGGGTGCCGAAAATGGTGACCGGCGAAGTCTTGGGCAGCTACTGTCTGACCGAGCCGGGCGCCGGCTCCGACGCCG
CCTCGCTGAAGACTCGCGCCGAGAAGAAAGGCGAGGTCTATGTGCTGAACGGCGGCAAGATGTTCATCTCCGGCGCCGGC
AGCACCCAGGTGCTGGTGGTGATGGCCCGCACCGGCGGCCCCGGCCCCAAGGGCATCTCCGCCTTCGTGGTGCCGGCCGA
CGCGCCGGGCGTCAGCTACGGCAAGAAGGAAAAGAAAATGGGTTGGAACAGCCAGCCCACCCGCGCCATCACCTTCGACA
ACGTCGAAATCCCGGTGGCAAACCGGCTGGGCGAGGAAGGCCAGGGATTCGCCTTCGCCATGAAGGGACTGGACGGCGGC
CGCATCAATATCGCCACCTGCGCCGTCGGCACCGCCCAGGCCGCGCTGAACGCCGCGCAGCGCTATGTGCAGGAACGCCA
GCAATTCGGCCACCCGCTGGCAGAATTGCAAACCGTGCAGTTCCGCCTGGCCGACATGCTGACCGAGCTGGTGGCCGCGC
GCCAGATGGTGCGCCTGGCCGCCTGGAAGCTGGACAATGCCAGCGCCGACGCCACCGCCTATTGCGCGATGGCAAAGCGC
CTGGCCACCGATCTGAGTTTCAATATCGCCAACAACGCGCTGCAGTTGTTCGGCGGCTACGGCTATCTGCAGGACTTCCC
GCTGGAGCGCCACGTGCGCGACCTGCGCGTGCACCAGATTCTGGAAGGCACCAACGAAGTGATGCGGATGATAGTCGGCC
GCAAGATGCTGCAGGACGGCGCGCTGGAAACGCTGCGCTAG

Upstream 100 bases:

>100_bases
AAGGTGCACACCACCATCTCGCTGCGCTGATTGTCGCGTAGGGCGGATGCCCCGTTAAGCGGGGCGATCCGCCTGCTCCG
TCTCAATAGGAACACAGAAC

Downstream 100 bases:

>100_bases
GCAAGGCCGGCAAAATCCCTGATGCTGCGTTGCGCCGGCTGGCCGTACTCATATGTACTGTCTGCGCCGGCGCGCCTTGC
CTCAGCCGCTGCGCTGGATT

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MNFELNEDQIAFQQSARDFAEHELAPHAAEWDAESLFPLDVIRKSGDMGFLGLYTPEAYGGLGLSRLDSAIVFEELAAGC
TSTAAYLTIHNMVSWMIASFGSKQLAEQWVPKMVTGEVLGSYCLTEPGAGSDAASLKTRAEKKGEVYVLNGGKMFISGAG
STQVLVVMARTGGPGPKGISAFVVPADAPGVSYGKKEKKMGWNSQPTRAITFDNVEIPVANRLGEEGQGFAFAMKGLDGG
RINIATCAVGTAQAALNAAQRYVQERQQFGHPLAELQTVQFRLADMLTELVAARQMVRLAAWKLDNASADATAYCAMAKR
LATDLSFNIANNALQLFGGYGYLQDFPLERHVRDLRVHQILEGTNEVMRMIVGRKMLQDGALETLR

Sequences:

>Translated_386_residues
MNFELNEDQIAFQQSARDFAEHELAPHAAEWDAESLFPLDVIRKSGDMGFLGLYTPEAYGGLGLSRLDSAIVFEELAAGC
TSTAAYLTIHNMVSWMIASFGSKQLAEQWVPKMVTGEVLGSYCLTEPGAGSDAASLKTRAEKKGEVYVLNGGKMFISGAG
STQVLVVMARTGGPGPKGISAFVVPADAPGVSYGKKEKKMGWNSQPTRAITFDNVEIPVANRLGEEGQGFAFAMKGLDGG
RINIATCAVGTAQAALNAAQRYVQERQQFGHPLAELQTVQFRLADMLTELVAARQMVRLAAWKLDNASADATAYCAMAKR
LATDLSFNIANNALQLFGGYGYLQDFPLERHVRDLRVHQILEGTNEVMRMIVGRKMLQDGALETLR
>Mature_386_residues
MNFELNEDQIAFQQSARDFAEHELAPHAAEWDAESLFPLDVIRKSGDMGFLGLYTPEAYGGLGLSRLDSAIVFEELAAGC
TSTAAYLTIHNMVSWMIASFGSKQLAEQWVPKMVTGEVLGSYCLTEPGAGSDAASLKTRAEKKGEVYVLNGGKMFISGAG
STQVLVVMARTGGPGPKGISAFVVPADAPGVSYGKKEKKMGWNSQPTRAITFDNVEIPVANRLGEEGQGFAFAMKGLDGG
RINIATCAVGTAQAALNAAQRYVQERQQFGHPLAELQTVQFRLADMLTELVAARQMVRLAAWKLDNASADATAYCAMAKR
LATDLSFNIANNALQLFGGYGYLQDFPLERHVRDLRVHQILEGTNEVMRMIVGRKMLQDGALETLR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=58.1333333333333, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=38.3202099737533, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=38.3202099737533, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=41.8421052631579, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=35.2941176470588, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=35.1706036745407, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI4501857, Length=371, Percent_Identity=35.0404312668464, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI226958414, Length=364, Percent_Identity=34.8901098901099, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI21361497, Length=356, Percent_Identity=34.2696629213483, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4557235, Length=398, Percent_Identity=31.6582914572864, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI76496475, Length=398, Percent_Identity=31.6582914572864, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=28.9124668435013, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI7669494, Length=356, Percent_Identity=28.9325842696629, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI48976061, Length=381, Percent_Identity=28.3464566929134, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI211971008, Length=381, Percent_Identity=28.3464566929134, Blast_Score=121, Evalue=9e-28,
Organism=Homo sapiens, GI38505218, Length=363, Percent_Identity=28.6501377410468, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=32.0209973753281, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=31.4432989690722, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87082384, Length=262, Percent_Identity=27.8625954198473, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=51.0928961748634, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=38.0829015544041, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=37.9581151832461, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=35.9580052493438, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=36.0526315789474, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=34.9726775956284, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=33.972602739726, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71985184, Length=349, Percent_Identity=33.2378223495702, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71990804, Length=285, Percent_Identity=36.8421052631579, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17505929, Length=376, Percent_Identity=31.1170212765957, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=29.973474801061, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=376, Percent_Identity=30.3191489361702, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.2294372294372, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71985192, Length=296, Percent_Identity=32.4324324324324, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=29.8181818181818, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17562446, Length=323, Percent_Identity=27.5541795665635, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17531909, Length=233, Percent_Identity=27.0386266094421, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=301, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI86563383, Length=301, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=38.3202099737533, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI21356377, Length=379, Percent_Identity=39.8416886543536, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.7659574468085, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=34.9869451697128, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24666513, Length=379, Percent_Identity=34.5646437994723, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI281363737, Length=346, Percent_Identity=33.8150289017341, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=28.9817232375979, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221473076, Length=330, Percent_Identity=26.0606060606061, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550141, Length=330, Percent_Identity=26.0606060606061, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24652780, Length=316, Percent_Identity=23.4177215189873, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41799; Mature: 41799

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFELNEDQIAFQQSARDFAEHELAPHAAEWDAESLFPLDVIRKSGDMGFLGLYTPEAYG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCHHHC
GLGLSRLDSAIVFEELAAGCTSTAAYLTIHNMVSWMIASFGSKQLAEQWVPKMVTGEVLG
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SYCLTEPGAGSDAASLKTRAEKKGEVYVLNGGKMFISGAGSTQVLVVMARTGGPGPKGIS
HHHCCCCCCCCCHHHHHHHHHCCCCEEEEECCEEEEECCCCCEEEEEEEECCCCCCCCCE
AFVVPADAPGVSYGKKEKKMGWNSQPTRAITFDNVEIPVANRLGEEGQGFAFAMKGLDGG
EEEEECCCCCCCCCCHHHHCCCCCCCCEEEEECCEEECHHHHCCCCCCCEEEEEECCCCC
RINIATCAVGTAQAALNAAQRYVQERQQFGHPLAELQTVQFRLADMLTELVAARQMVRLA
EEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWKLDNASADATAYCAMAKRLATDLSFNIANNALQLFGGYGYLQDFPLERHVRDLRVHQI
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHH
LEGTNEVMRMIVGRKMLQDGALETLR
HHHHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MNFELNEDQIAFQQSARDFAEHELAPHAAEWDAESLFPLDVIRKSGDMGFLGLYTPEAYG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCHHHC
GLGLSRLDSAIVFEELAAGCTSTAAYLTIHNMVSWMIASFGSKQLAEQWVPKMVTGEVLG
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SYCLTEPGAGSDAASLKTRAEKKGEVYVLNGGKMFISGAGSTQVLVVMARTGGPGPKGIS
HHHCCCCCCCCCHHHHHHHHHCCCCEEEEECCEEEEECCCCCEEEEEEEECCCCCCCCCE
AFVVPADAPGVSYGKKEKKMGWNSQPTRAITFDNVEIPVANRLGEEGQGFAFAMKGLDGG
EEEEECCCCCCCCCCHHHHCCCCCCCCEEEEECCEEECHHHHCCCCCCCEEEEEECCCCC
RINIATCAVGTAQAALNAAQRYVQERQQFGHPLAELQTVQFRLADMLTELVAARQMVRLA
EEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWKLDNASADATAYCAMAKRLATDLSFNIANNALQLFGGYGYLQDFPLERHVRDLRVHQI
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHH
LEGTNEVMRMIVGRKMLQDGALETLR
HHHHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]