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The map label for this gene is mucB [H]

Identifier: 34497515

GI number: 34497515

Start: 2247578

End: 2248543

Strand: Direct

Name: mucB [H]

Synonym: CV_2060

Alternate gene names: 34497515

Gene position: 2247578-2248543 (Clockwise)

Preceding gene: 34497514

Following gene: 34497516

Centisome position: 47.31

GC content: 65.84

Gene sequence:

>966_bases
ATGCGTGTCGTTCCTCTGATTGGTGTTTTGATGTTCGGGGCCGCGTGCGCGGCCCATGCGGAGGATGACATGCAGCTGCT
GCGCAATGTCGGCAACGCCGGCAGGCAGCAGCCGCTGGATGGCACCTATCTGCATCAGATGAATGGCACGCTGGAAACCT
TCCGCATCGTCCGCCAGGGGCAAGGCGACAATGTGCGCGAAAAGCGCACTTCGCTGGACGGTCCGACGCGGGAGGTGGTT
CGCAAGGGAAGGGAGCTCACCTGCTTCGCGCCCGACAAGCGCGCCCTGATGGCGTGCAAGATCAGCGCGATGAGGCTGTT
CCCCGCCTTGCTGCCCGACGACCTCGACGACATTACCCGCTCCTATGCCCTCAAGCGCACCGGCCACGACCGCGTGGCCA
AGCGCGACTGCCAGTGGCTGGATCTGCAGCCGCGCGACGCGCAGCGTTACACGATGCGGATGTGCATCGAGCCCGCGACC
TATCTCCCTCTGAAAGTGATGACCTTGTCGCCGCGCGGCGACGCAGTCGAGCAGTTCACCTTCACGGATGTGGAGCTGGG
CGGGGCCAAGGATAAGCGGGCGTATGCTTCCAGGCTGTCGCAGCGCTTCCAGCTGCGCTCCGGCGCATCCGCGGGGAGCG
AGGAGGCGGCCGCTTCGCAAAGCGAGGTGACGGGCCTTCCGCAGGGCTTCCGGCTGTTGCGGTCGGTGCAGCGCGTGCTG
CCCGGCCAGGGCGGCAAGCCGGTTCGCCACATGGTGCTGAGCGATGGCCTGGTCATGCTGTCGGTGTTCGTCGAGCCGCC
GCCGCCGGAGCATGCGCGCCTGGAAAAGGTGGGCAATCTGCACGGGGCGATCAACATGGCCACCAGCTACCAGGGGGATA
TGCAGCTGACCGCGGTGGGCGACATGCCGCAAACCGCGATGATGGCTCTGCTCAAGGGCTTGCATGTCAACGGCAAGGGT
GACTGA

Upstream 100 bases:

>100_bases
CGGTGATGGACCAGGATGATCCCTATGTGCTGGCGCACCAGGAGGTGACCGCAGACCAGAGCGTGATGCGAGTGTCCTAT
GGAAACGGAGCTCGCCACTG

Downstream 100 bases:

>100_bases
GCCCGTGTCCGGCGCGGGAGCGGATTGGGCATCGCGCGGGGATTCTTCCGCGGGTGCGCCGTTCGCCGTCCGGTGATGAT
CATGGCTGGCCATTCCGAAT

Product: negative regulator for alginate biosynthesis MucB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MRVVPLIGVLMFGAACAAHAEDDMQLLRNVGNAGRQQPLDGTYLHQMNGTLETFRIVRQGQGDNVREKRTSLDGPTREVV
RKGRELTCFAPDKRALMACKISAMRLFPALLPDDLDDITRSYALKRTGHDRVAKRDCQWLDLQPRDAQRYTMRMCIEPAT
YLPLKVMTLSPRGDAVEQFTFTDVELGGAKDKRAYASRLSQRFQLRSGASAGSEEAAASQSEVTGLPQGFRLLRSVQRVL
PGQGGKPVRHMVLSDGLVMLSVFVEPPPPEHARLEKVGNLHGAINMATSYQGDMQLTAVGDMPQTAMMALLKGLHVNGKG
D

Sequences:

>Translated_321_residues
MRVVPLIGVLMFGAACAAHAEDDMQLLRNVGNAGRQQPLDGTYLHQMNGTLETFRIVRQGQGDNVREKRTSLDGPTREVV
RKGRELTCFAPDKRALMACKISAMRLFPALLPDDLDDITRSYALKRTGHDRVAKRDCQWLDLQPRDAQRYTMRMCIEPAT
YLPLKVMTLSPRGDAVEQFTFTDVELGGAKDKRAYASRLSQRFQLRSGASAGSEEAAASQSEVTGLPQGFRLLRSVQRVL
PGQGGKPVRHMVLSDGLVMLSVFVEPPPPEHARLEKVGNLHGAINMATSYQGDMQLTAVGDMPQTAMMALLKGLHVNGKG
D
>Mature_321_residues
MRVVPLIGVLMFGAACAAHAEDDMQLLRNVGNAGRQQPLDGTYLHQMNGTLETFRIVRQGQGDNVREKRTSLDGPTREVV
RKGRELTCFAPDKRALMACKISAMRLFPALLPDDLDDITRSYALKRTGHDRVAKRDCQWLDLQPRDAQRYTMRMCIEPAT
YLPLKVMTLSPRGDAVEQFTFTDVELGGAKDKRAYASRLSQRFQLRSGASAGSEEAAASQSEVTGLPQGFRLLRSVQRVL
PGQGGKPVRHMVLSDGLVMLSVFVEPPPPEHARLEKVGNLHGAINMATSYQGDMQLTAVGDMPQTAMMALLKGLHVNGKG
D

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=304, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 35329; Mature: 35329

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVPLIGVLMFGAACAAHAEDDMQLLRNVGNAGRQQPLDGTYLHQMNGTLETFRIVRQG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHCC
QGDNVREKRTSLDGPTREVVRKGRELTCFAPDKRALMACKISAMRLFPALLPDDLDDITR
CCCCHHHHHHCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
SYALKRTGHDRVAKRDCQWLDLQPRDAQRYTMRMCIEPATYLPLKVMTLSPRGDAVEQFT
HHHHHHCCCHHHHHCCCCEECCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHEE
FTDVELGGAKDKRAYASRLSQRFQLRSGASAGSEEAAASQSEVTGLPQGFRLLRSVQRVL
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHCCCCHHHHHHHHHHHHC
PGQGGKPVRHMVLSDGLVMLSVFVEPPPPEHARLEKVGNLHGAINMATSYQGDMQLTAVG
CCCCCCHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHCHHHHEEEEECCCCCEEEEEEC
DMPQTAMMALLKGLHVNGKGD
CCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRVVPLIGVLMFGAACAAHAEDDMQLLRNVGNAGRQQPLDGTYLHQMNGTLETFRIVRQG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHCC
QGDNVREKRTSLDGPTREVVRKGRELTCFAPDKRALMACKISAMRLFPALLPDDLDDITR
CCCCHHHHHHCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
SYALKRTGHDRVAKRDCQWLDLQPRDAQRYTMRMCIEPATYLPLKVMTLSPRGDAVEQFT
HHHHHHCCCHHHHHCCCCEECCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHEE
FTDVELGGAKDKRAYASRLSQRFQLRSGASAGSEEAAASQSEVTGLPQGFRLLRSVQRVL
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHCCCCHHHHHHHHHHHHC
PGQGGKPVRHMVLSDGLVMLSVFVEPPPPEHARLEKVGNLHGAINMATSYQGDMQLTAVG
CCCCCCHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHCHHHHEEEEECCCCCEEEEEEC
DMPQTAMMALLKGLHVNGKGD
CCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]