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The map label for this gene is mucD [H]

Identifier: 34497516

GI number: 34497516

Start: 2248802

End: 2250214

Strand: Direct

Name: mucD [H]

Synonym: CV_2061

Alternate gene names: 34497516

Gene position: 2248802-2250214 (Clockwise)

Preceding gene: 34497515

Following gene: 34497517

Centisome position: 47.33

GC content: 65.39

Gene sequence:

>1413_bases
ATGTCGGTCAAAAAACTGATTGTTTCTGCAATGCTGGCGGCATCTGTCCTGACTGCCGCGGCGCCTGCCGCGATGGCGGC
GGACCTGCCGGATTTCGCCCAGATCGTCGAGGCCGAAGGCAAGGCGGTGGTCAATATCAGCACCACCTCCACGGTCAAGG
AGATGGTTTCCGGCCTGCCGGAGGGCATGGAGGGGGATCCGTTCTTCGAGTTCTTCCGCCGCTTCGCGCCGCCGCAGCAG
CGCGAGCATCAGGAAAGCTCGCTGGGTTCCGGCTTCATCATTTCGCGGGACGGCTATGTGCTGACCAATGCGCATGTGGT
GGCCCGCGCGGACAAGATTACCGTCAAGCTGAACGACAAGCGCGAATTCCAGGCGCGGGTGATCGGTTCCGACGCCCGTT
CCGACGTGGCGCTGCTGAAGATCGATGCCCAGAACCTGCCGGTGGTGCGGATGGGCGATCCGAAAAGCCTGAAGGTGGGG
CAGTGGGTGCTGGCCATCGGCTCGCCCTTCGGTTTTGAGAACACCGCGACTTCCGGCATCGTGTCCGGCAAGAACCGCAT
GCTGCCGGATGAGAGCGCCGTGCAGTTCATCCAGACCGACGCCGCGGTGAATCCCGGCAATTCCGGCGGCCCGCTGTTCA
ATCTGAAGGGCGAGGTGGTCGGCGTCAATTCGCAGATCTACAGCCGTTCCGGCGGCTTCATGGGCATTTCCTTCGCCATT
CCGATCGATACCGCGATGAATGTCGCCGACCAGTTGAAGGCCAAGGGCAAGGTCACCCGCAGCCGCATCGGCGTGGTGGT
GCAGGAGCTGAGCAAGGAGTTGGCGGCGTCCTTCGGCCTGGCCAAGCCCAGCGGCGTGCTGATCAACGCGCTCGATCCCA
AGGGGCCGGCACAGAAGGCCGGCCTGAAGGCGGGCGACATCGTGCTGCGCATCAATGGCCAGGCGGTGGAGAACGGCGGC
GACATGCAGCGCCTGATCAGCGACCTGCCGCCGGGCAAGGCGATCACGCTGGATGTCTGGCGCAGCCGCGCGCAGACCAG
CGTCCGCGTGGTGCCGGACGAACTGGTGGAGGAGGATGCCCGCGTCGCCAAGCGCGAATACCGCAAGCCCGGCGCCGAGG
CTGAGCAGAACCTGGCCCAGATCGGCTTGCGCCTGCAGGAGCTGAGCCCCGTCCAGCTGCAGCGCGCCGGCATCGATTAC
GGCTTGCTGGTGCGCGGCGCCAACGGCGCGGCGATGCGCGCCGGCATCCAGCCGGGCGACATCATCGTCGGCATCGGCAG
CGATCCGCTGAAGAACTTCGCCCAGCTGAAGAATGCGCTGAACCAGGCCAAGAAAGGCGGCGCCGTGGCCTTGCAGGTGA
TGCGTCAGGGCGTGACCATGTTCGTGCCGCTGACCGTGGACGAAGCCAAGTGA

Upstream 100 bases:

>100_bases
GCGTGAGGGGCGCGGCGTGGCGCCGTTTCCCGATCCGATGGTTGCAAAGCCGGCGTCCGCCGGCATATACAGTCCACAAC
ATTCCAAAGATGGAGCGCGC

Downstream 100 bases:

>100_bases
CGCTGACGCTGTACTTCCGCGAATATTGCAGCCTGTGCCACCAGATGCTGGCGGAGCTCGCGCCTTGGCGCGAGCGCCAC
GGCTTCGAGCTGGAGGTGGT

Product: serine protease MucD

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSVKKLIVSAMLAASVLTAAAPAAMAADLPDFAQIVEAEGKAVVNISTTSTVKEMVSGLPEGMEGDPFFEFFRRFAPPQQ
REHQESSLGSGFIISRDGYVLTNAHVVARADKITVKLNDKREFQARVIGSDARSDVALLKIDAQNLPVVRMGDPKSLKVG
QWVLAIGSPFGFENTATSGIVSGKNRMLPDESAVQFIQTDAAVNPGNSGGPLFNLKGEVVGVNSQIYSRSGGFMGISFAI
PIDTAMNVADQLKAKGKVTRSRIGVVVQELSKELAASFGLAKPSGVLINALDPKGPAQKAGLKAGDIVLRINGQAVENGG
DMQRLISDLPPGKAITLDVWRSRAQTSVRVVPDELVEEDARVAKREYRKPGAEAEQNLAQIGLRLQELSPVQLQRAGIDY
GLLVRGANGAAMRAGIQPGDIIVGIGSDPLKNFAQLKNALNQAKKGGAVALQVMRQGVTMFVPLTVDEAK

Sequences:

>Translated_470_residues
MSVKKLIVSAMLAASVLTAAAPAAMAADLPDFAQIVEAEGKAVVNISTTSTVKEMVSGLPEGMEGDPFFEFFRRFAPPQQ
REHQESSLGSGFIISRDGYVLTNAHVVARADKITVKLNDKREFQARVIGSDARSDVALLKIDAQNLPVVRMGDPKSLKVG
QWVLAIGSPFGFENTATSGIVSGKNRMLPDESAVQFIQTDAAVNPGNSGGPLFNLKGEVVGVNSQIYSRSGGFMGISFAI
PIDTAMNVADQLKAKGKVTRSRIGVVVQELSKELAASFGLAKPSGVLINALDPKGPAQKAGLKAGDIVLRINGQAVENGG
DMQRLISDLPPGKAITLDVWRSRAQTSVRVVPDELVEEDARVAKREYRKPGAEAEQNLAQIGLRLQELSPVQLQRAGIDY
GLLVRGANGAAMRAGIQPGDIIVGIGSDPLKNFAQLKNALNQAKKGGAVALQVMRQGVTMFVPLTVDEAK
>Mature_469_residues
SVKKLIVSAMLAASVLTAAAPAAMAADLPDFAQIVEAEGKAVVNISTTSTVKEMVSGLPEGMEGDPFFEFFRRFAPPQQR
EHQESSLGSGFIISRDGYVLTNAHVVARADKITVKLNDKREFQARVIGSDARSDVALLKIDAQNLPVVRMGDPKSLKVGQ
WVLAIGSPFGFENTATSGIVSGKNRMLPDESAVQFIQTDAAVNPGNSGGPLFNLKGEVVGVNSQIYSRSGGFMGISFAIP
IDTAMNVADQLKAKGKVTRSRIGVVVQELSKELAASFGLAKPSGVLINALDPKGPAQKAGLKAGDIVLRINGQAVENGGD
MQRLISDLPPGKAITLDVWRSRAQTSVRVVPDELVEEDARVAKREYRKPGAEAEQNLAQIGLRLQELSPVQLQRAGIDYG
LLVRGANGAAMRAGIQPGDIIVGIGSDPLKNFAQLKNALNQAKKGGAVALQVMRQGVTMFVPLTVDEAK

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=304, Percent_Identity=37.171052631579, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI24308541, Length=283, Percent_Identity=34.6289752650177, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI7019477, Length=284, Percent_Identity=36.9718309859155, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI22129776, Length=259, Percent_Identity=35.5212355212355, Blast_Score=153, Evalue=4e-37,
Organism=Escherichia coli, GI1789629, Length=470, Percent_Identity=35.7446808510638, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1786356, Length=463, Percent_Identity=33.4773218142549, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1789630, Length=289, Percent_Identity=33.9100346020761, Blast_Score=171, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24646839, Length=293, Percent_Identity=35.4948805460751, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 49815; Mature: 49684

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKKLIVSAMLAASVLTAAAPAAMAADLPDFAQIVEAEGKAVVNISTTSTVKEMVSGLP
CCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHCCC
EGMEGDPFFEFFRRFAPPQQREHQESSLGSGFIISRDGYVLTNAHVVARADKITVKLNDK
CCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCEEEECCEEEEEEEEEEEEECCC
REFQARVIGSDARSDVALLKIDAQNLPVVRMGDPKSLKVGQWVLAIGSPFGFENTATSGI
CCEEEEEECCCCCCCEEEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCE
VSGKNRMLPDESAVQFIQTDAAVNPGNSGGPLFNLKGEVVGVNSQIYSRSGGFMGISFAI
ECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEECHHHHHCCCCEEEEEEEE
PIDTAMNVADQLKAKGKVTRSRIGVVVQELSKELAASFGLAKPSGVLINALDPKGPAQKA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHC
GLKAGDIVLRINGQAVENGGDMQRLISDLPPGKAITLDVWRSRAQTSVRVVPDELVEEDA
CCCCCCEEEEECCEEECCCCHHHHHHHHCCCCCEEEHHHHHCCCCCEEEECCHHHHHHHH
RVAKREYRKPGAEAEQNLAQIGLRLQELSPVQLQRAGIDYGLLVRGANGAAMRAGIQPGD
HHHHHHHCCCCCHHHHHHHHHCCCHHCCCCHHHHHCCCCEEEEEECCCCCEEECCCCCCC
IIVGIGSDPLKNFAQLKNALNQAKKGGAVALQVMRQGVTMFVPLTVDEAK
EEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEECCCC
>Mature Secondary Structure 
SVKKLIVSAMLAASVLTAAAPAAMAADLPDFAQIVEAEGKAVVNISTTSTVKEMVSGLP
CHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHCCC
EGMEGDPFFEFFRRFAPPQQREHQESSLGSGFIISRDGYVLTNAHVVARADKITVKLNDK
CCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCEEEECCEEEEEEEEEEEEECCC
REFQARVIGSDARSDVALLKIDAQNLPVVRMGDPKSLKVGQWVLAIGSPFGFENTATSGI
CCEEEEEECCCCCCCEEEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCE
VSGKNRMLPDESAVQFIQTDAAVNPGNSGGPLFNLKGEVVGVNSQIYSRSGGFMGISFAI
ECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEECHHHHHCCCCEEEEEEEE
PIDTAMNVADQLKAKGKVTRSRIGVVVQELSKELAASFGLAKPSGVLINALDPKGPAQKA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHC
GLKAGDIVLRINGQAVENGGDMQRLISDLPPGKAITLDVWRSRAQTSVRVVPDELVEEDA
CCCCCCEEEEECCEEECCCCHHHHHHHHCCCCCEEEHHHHHCCCCCEEEECCHHHHHHHH
RVAKREYRKPGAEAEQNLAQIGLRLQELSPVQLQRAGIDYGLLVRGANGAAMRAGIQPGD
HHHHHHHCCCCCHHHHHHHHHCCCHHCCCCHHHHHCCCCEEEEEECCCCCEEECCCCCCC
IIVGIGSDPLKNFAQLKNALNQAKKGGAVALQVMRQGVTMFVPLTVDEAK
EEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]