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The map label for this gene is hmgA [H]

Identifier: 34497261

GI number: 34497261

Start: 1964132

End: 1965217

Strand: Direct

Name: hmgA [H]

Synonym: CV_1806

Alternate gene names: 34497261

Gene position: 1964132-1965217 (Clockwise)

Preceding gene: 34497260

Following gene: 34497262

Centisome position: 41.34

GC content: 67.4

Gene sequence:

>1086_bases
CTGGGCACTTGCGAGAACTATGTCGGCACCGTCGGCGTGCCGGTCGGCCTGGCCGGGCCGCTCGCCATTCACGGCAGCCG
GGCGCAGGGGGAGTTCGTCGTGCCGATGGCGACGACGGAGGGCGCGCTGGTGGCGTCCTTCTCGCGCGGCATGAGCATCA
TCACCGAAAGCGGAGGTTGCCATGTGCTGAGCCCGGGCAATGTCCTGCCGGGCGAGACCGGGCAGCCGTACCGCGTGCTG
GGCGACGCGCTGACCAAGATCTCCGCCGTGGTGCTGCGGGACGCGGCCGAGGCCGGCCGGTTCGACGGCTGGTTGCGAGA
ACACCTGCCGCAGATCGTCGCCGCAGCCAACGCCACCAGCCGATTCGCCAGGCTGCTGGAAGTCAGCCCGCTGTTCCATG
GCGACTTGGTCGGCCTCGCCTTCACCTACTCCACAGACCAGGCGATGGGGCTGAATATGGCGACCAAGGCCAATGAAGCG
GCTTGTCGCTATATCCTCGCCCACAGCGGCGGCTTGGCCATCGACTATTTCAACACTTTGGGAGGGGACAAGCGCTTTGT
GCCGGACCAGGCCAAGGGACGGTACGTGTCGGCCAGCGTCAGAATCCCGGCCCAGTTGCTGCAACAGCGGCTGCGCACCA
CGGCGCACAGGATGCGGCGCTTCCTCGGAGCCTGCAATATCCTGCTGGCTCAGCGCGGCGCCACGGCGCCCAATATCCAT
ATCGCCAATGCGCTGACGGCCATGTTCATCGCCTGCGGCCAGGACCCGGCTTTCGTCACGGTGTCGTTCAAGAACGCCAG
CACCATGTTCGAGCCGCAGAGCAACGGCGATCTGCTCGCCTCTGTGACGCTGCCCAATTTGTTGCTGGGCACGGTCGGCG
GCGGAGTCAAGCTGCCGGGGCAGCAGGAATGCCTGCGGATGCTGGGCTGCGAGGACGACGTGATCAAGCTGGCCGAGATC
ATCGCCGCCGTCGCGCTGGCCGGCGAAGTCTCGGTGGCGGGCGCCGTGACGGCGGGCGAGTTCACGCATGCGCACACCGT
GCTGGGGCGCGGGCTGCACGGCGACAATGCGGAGCGCAAGGCATGA

Upstream 100 bases:

>100_bases
CAGCCAGGCAATCATCGCGCAACGCCACGGCTGGCTGGAGACGTTCACCGGGCAGCATTTTCCGTATTTGCAGGGACGGC
CCTACGAGCCGGGCTCGGTG

Downstream 100 bases:

>100_bases
TACGGCGGCTGCTGCTCTGTTGCCGCGGCGAGATCGCGCTGCGCTTCATCCGCACTTGCCGCTTGATGGGTGTGGAAACC
GTGGCGGCTTATCCGGCGGA

Product: hydroxymethylglutaryl-CoA reductase (NADPH2)

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MGTCENYVGTVGVPVGLAGPLAIHGSRAQGEFVVPMATTEGALVASFSRGMSIITESGGCHVLSPGNVLPGETGQPYRVL
GDALTKISAVVLRDAAEAGRFDGWLREHLPQIVAAANATSRFARLLEVSPLFHGDLVGLAFTYSTDQAMGLNMATKANEA
ACRYILAHSGGLAIDYFNTLGGDKRFVPDQAKGRYVSASVRIPAQLLQQRLRTTAHRMRRFLGACNILLAQRGATAPNIH
IANALTAMFIACGQDPAFVTVSFKNASTMFEPQSNGDLLASVTLPNLLLGTVGGGVKLPGQQECLRMLGCEDDVIKLAEI
IAAVALAGEVSVAGAVTAGEFTHAHTVLGRGLHGDNAERKA

Sequences:

>Translated_361_residues
MGTCENYVGTVGVPVGLAGPLAIHGSRAQGEFVVPMATTEGALVASFSRGMSIITESGGCHVLSPGNVLPGETGQPYRVL
GDALTKISAVVLRDAAEAGRFDGWLREHLPQIVAAANATSRFARLLEVSPLFHGDLVGLAFTYSTDQAMGLNMATKANEA
ACRYILAHSGGLAIDYFNTLGGDKRFVPDQAKGRYVSASVRIPAQLLQQRLRTTAHRMRRFLGACNILLAQRGATAPNIH
IANALTAMFIACGQDPAFVTVSFKNASTMFEPQSNGDLLASVTLPNLLLGTVGGGVKLPGQQECLRMLGCEDDVIKLAEI
IAAVALAGEVSVAGAVTAGEFTHAHTVLGRGLHGDNAERKA
>Mature_360_residues
GTCENYVGTVGVPVGLAGPLAIHGSRAQGEFVVPMATTEGALVASFSRGMSIITESGGCHVLSPGNVLPGETGQPYRVLG
DALTKISAVVLRDAAEAGRFDGWLREHLPQIVAAANATSRFARLLEVSPLFHGDLVGLAFTYSTDQAMGLNMATKANEAA
CRYILAHSGGLAIDYFNTLGGDKRFVPDQAKGRYVSASVRIPAQLLQQRLRTTAHRMRRFLGACNILLAQRGATAPNIHI
ANALTAMFIACGQDPAFVTVSFKNASTMFEPQSNGDLLASVTLPNLLLGTVGGGVKLPGQQECLRMLGCEDDVIKLAEII
AAVALAGEVSVAGAVTAGEFTHAHTVLGRGLHGDNAERKA

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=375, Percent_Identity=34.4, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI196049380, Length=305, Percent_Identity=32.7868852459016, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI25144592, Length=379, Percent_Identity=34.5646437994723, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323565, Length=365, Percent_Identity=31.5068493150685, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323483, Length=371, Percent_Identity=31.266846361186, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI281362379, Length=365, Percent_Identity=34.2465753424658, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45553469, Length=365, Percent_Identity=34.2465753424658, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24649399, Length=365, Percent_Identity=34.2465753424658, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 37763; Mature: 37632

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTCENYVGTVGVPVGLAGPLAIHGSRAQGEFVVPMATTEGALVASFSRGMSIITESGGC
CCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCHHHHHHHCCCEEEECCCCE
HVLSPGNVLPGETGQPYRVLGDALTKISAVVLRDAAEAGRFDGWLREHLPQIVAAANATS
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHH
RFARLLEVSPLFHGDLVGLAFTYSTDQAMGLNMATKANEAACRYILAHSGGLAIDYFNTL
HHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHEEEEECCCCEEEEEHHHC
GGDKRFVPDQAKGRYVSASVRIPAQLLQQRLRTTAHRMRRFLGACNILLAQRGATAPNIH
CCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEE
IANALTAMFIACGQDPAFVTVSFKNASTMFEPQSNGDLLASVTLPNLLLGTVGGGVKLPG
HHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCEEEEECHHHHHHHHCCCCCCCCC
QQECLRMLGCEDDVIKLAEIIAAVALAGEVSVAGAVTAGEFTHAHTVLGRGLHGDNAERK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCC
A
C
>Mature Secondary Structure 
GTCENYVGTVGVPVGLAGPLAIHGSRAQGEFVVPMATTEGALVASFSRGMSIITESGGC
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCHHHHHHHCCCEEEECCCCE
HVLSPGNVLPGETGQPYRVLGDALTKISAVVLRDAAEAGRFDGWLREHLPQIVAAANATS
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHH
RFARLLEVSPLFHGDLVGLAFTYSTDQAMGLNMATKANEAACRYILAHSGGLAIDYFNTL
HHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHEEEEECCCCEEEEEHHHC
GGDKRFVPDQAKGRYVSASVRIPAQLLQQRLRTTAHRMRRFLGACNILLAQRGATAPNIH
CCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEE
IANALTAMFIACGQDPAFVTVSFKNASTMFEPQSNGDLLASVTLPNLLLGTVGGGVKLPG
HHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCEEEEECHHHHHHHHCCCCCCCCC
QQECLRMLGCEDDVIKLAEIIAAVALAGEVSVAGAVTAGEFTHAHTVLGRGLHGDNAERK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1556098 [H]