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The map label for this gene is mmdA [H]

Identifier: 34497260

GI number: 34497260

Start: 1962488

End: 1963984

Strand: Direct

Name: mmdA [H]

Synonym: CV_1805

Alternate gene names: 34497260

Gene position: 1962488-1963984 (Clockwise)

Preceding gene: 34497259

Following gene: 34497261

Centisome position: 41.31

GC content: 65.4

Gene sequence:

>1497_bases
ATGACGACGGTTCAGGCCTCTTTTTCCGCCACGGGCACGCCGCGGCGTGATTCCGCGGTATGGCAGGCCATAGAGTGGCT
GGTCGATAGCGGCAGTTTTTACCAGCTGGACGCGCTGAGCGAGCATGATTGCCAGCACTTCGGCACCGCCGGCCGCAAGG
TACCCGGCGATGGCCTGGTGACCGGGCATGGCCGGATCGACGGCCGGCCTGTGCTGGTTTACGCCCATGACCGCGATTTT
CTCGGCGGCAGTTCCAGCCGGGTGCATGCGGTGCGGATAGGCAAGTTGCTGGACATGGCGCTGCAGCTTGGCCTGCCGGT
GATAGGCCTCAACGATTCCTCCGGGATTCGGATACACGAAGGAGTCGACGCCGGCGCGCAATTCAGCGAGGTGTTCCACA
AGACGGTCAAGGCTTCCGGCGTGGTGCCGCAGATCTCGGTGATCCTGGGCGACTGCGCCGGGGGCGCGGCCTATGCGCCG
GCCTTGACCGACTTCATCGTCATGGCGGGCGCGGAGTCGACGATGTTCCTGACCGGGCCGTCGGTGATCCGTTCGGCGAC
GGGCGAAAGCGTCACCAAGGAGGAGATCGGCGGCGCGCAGCTGCATGCCGAAGTCACTGGCTTGGCTCATTTCAATTGTG
ATGGACGCGAGCAGGCGGTGGCGCTGGTGCGGGAGCTGCTCGGTTACCTGCCGCAGAACAACGCCAGTCCGACGCCGCGC
GTCGATCGCGGGGATACCGGTCCCAGGCGCACCCCGCGCCTGGAGCGGCTGATTCCAGCCCATCAGAACGAACCCTACGA
TGTGCTGGATGTCGTCGCCGAAATCGCCGACAACAACGAATTCCTCGAAATCCAGGCCCAGTACGCCCCAAACCTGGTGA
CCGGCTTCGCCCGCTTCGGCGGGCGCACTGTTGGCGTGCTGGCCAGCCAGCCGTTGCAGCGCGCAGGTTGTCTCGATGTC
GACTCCTCGCTGAAGGGCGCTCGCTTCGTGCGCTTGTGCGACAGCTTCGATATCCCGCTGTTGACGCTGCTGGACGTGCC
CGGCTACTTGCCCGGCCGCGAACAGGAGACGCGCGGCATCATCGGCGCCGGGGCCAAGCTGCTGCACGCCTATTGCGAGG
CCAGCGTGCCCAAGCTGGCCATCGTGCTGCGCAAGGCTTACGGCGGCGCTTATCCGACGCTGGCCAATTGGTCCGCGACC
GACTTCACCTTCGCATTGGAGCAGGCGGAAATCGCCGTGATGGGGCCGCAAGGGGCGGTCGACATCATTTTCCGCAGAGA
GCTGGCCGCCGCGGCGGATCCTGCGTCATTGAGGGAGAAGCTGCTGGACGACTACCGCGCAGCGCATGCCAATGCGTCGT
ATTCCGCCAAGAAAGGTTATGTGGATGGCTTGCTGGCTGCCGCTGAAGTGCGCAACGCCGTGCTGTCCCATCTGCAGCTG
CTGGCGGACAAGGTGGGCGGCACCCCGGCCCGCCGCCATTCCAACATCCCGCTTTAG

Upstream 100 bases:

>100_bases
CAGCGACGGCATATCCCGATCGTGGCCAGATAACGCCGGCGGTTGCCGTGTTCCGGCCATGGAGTTGAACGATGATTGAC
AACAGAGAAGGCAAGCGACG

Downstream 100 bases:

>100_bases
AAAGGTCTGTATCTCATGAAGATTCCCCGTTCCAAGGAAGACGATTACAGCCAGGCAATCATCGCGCAACGCCACGGCTG
GCTGGAGACGTTCACCGGGC

Product: acetyl-CoA carboxylase subunit alpha

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTTVQASFSATGTPRRDSAVWQAIEWLVDSGSFYQLDALSEHDCQHFGTAGRKVPGDGLVTGHGRIDGRPVLVYAHDRDF
LGGSSSRVHAVRIGKLLDMALQLGLPVIGLNDSSGIRIHEGVDAGAQFSEVFHKTVKASGVVPQISVILGDCAGGAAYAP
ALTDFIVMAGAESTMFLTGPSVIRSATGESVTKEEIGGAQLHAEVTGLAHFNCDGREQAVALVRELLGYLPQNNASPTPR
VDRGDTGPRRTPRLERLIPAHQNEPYDVLDVVAEIADNNEFLEIQAQYAPNLVTGFARFGGRTVGVLASQPLQRAGCLDV
DSSLKGARFVRLCDSFDIPLLTLLDVPGYLPGREQETRGIIGAGAKLLHAYCEASVPKLAIVLRKAYGGAYPTLANWSAT
DFTFALEQAEIAVMGPQGAVDIIFRRELAAAADPASLREKLLDDYRAAHANASYSAKKGYVDGLLAAAEVRNAVLSHLQL
LADKVGGTPARRHSNIPL

Sequences:

>Translated_498_residues
MTTVQASFSATGTPRRDSAVWQAIEWLVDSGSFYQLDALSEHDCQHFGTAGRKVPGDGLVTGHGRIDGRPVLVYAHDRDF
LGGSSSRVHAVRIGKLLDMALQLGLPVIGLNDSSGIRIHEGVDAGAQFSEVFHKTVKASGVVPQISVILGDCAGGAAYAP
ALTDFIVMAGAESTMFLTGPSVIRSATGESVTKEEIGGAQLHAEVTGLAHFNCDGREQAVALVRELLGYLPQNNASPTPR
VDRGDTGPRRTPRLERLIPAHQNEPYDVLDVVAEIADNNEFLEIQAQYAPNLVTGFARFGGRTVGVLASQPLQRAGCLDV
DSSLKGARFVRLCDSFDIPLLTLLDVPGYLPGREQETRGIIGAGAKLLHAYCEASVPKLAIVLRKAYGGAYPTLANWSAT
DFTFALEQAEIAVMGPQGAVDIIFRRELAAAADPASLREKLLDDYRAAHANASYSAKKGYVDGLLAAAEVRNAVLSHLQL
LADKVGGTPARRHSNIPL
>Mature_497_residues
TTVQASFSATGTPRRDSAVWQAIEWLVDSGSFYQLDALSEHDCQHFGTAGRKVPGDGLVTGHGRIDGRPVLVYAHDRDFL
GGSSSRVHAVRIGKLLDMALQLGLPVIGLNDSSGIRIHEGVDAGAQFSEVFHKTVKASGVVPQISVILGDCAGGAAYAPA
LTDFIVMAGAESTMFLTGPSVIRSATGESVTKEEIGGAQLHAEVTGLAHFNCDGREQAVALVRELLGYLPQNNASPTPRV
DRGDTGPRRTPRLERLIPAHQNEPYDVLDVVAEIADNNEFLEIQAQYAPNLVTGFARFGGRTVGVLASQPLQRAGCLDVD
SSLKGARFVRLCDSFDIPLLTLLDVPGYLPGREQETRGIIGAGAKLLHAYCEASVPKLAIVLRKAYGGAYPTLANWSATD
FTFALEQAEIAVMGPQGAVDIIFRRELAAAADPASLREKLLDDYRAAHANASYSAKKGYVDGLLAAAEVRNAVLSHLQLL
ADKVGGTPARRHSNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=480, Percent_Identity=45.8333333333333, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI295821216, Length=500, Percent_Identity=44.2, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI11545863, Length=471, Percent_Identity=31.2101910828025, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI134142062, Length=323, Percent_Identity=25.077399380805, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=478, Percent_Identity=45.397489539749, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI25147359, Length=478, Percent_Identity=45.397489539749, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17552936, Length=479, Percent_Identity=29.4363256784969, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24586065, Length=493, Percent_Identity=30.6288032454361, Blast_Score=199, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 53007; Mature: 52875

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVQASFSATGTPRRDSAVWQAIEWLVDSGSFYQLDALSEHDCQHFGTAGRKVPGDGLV
CCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCCCCCCCEE
TGHGRIDGRPVLVYAHDRDFLGGSSSRVHAVRIGKLLDMALQLGLPVIGLNDSSGIRIHE
ECCCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEECCCCCEEEEC
GVDAGAQFSEVFHKTVKASGVVPQISVILGDCAGGAAYAPALTDFIVMAGAESTMFLTGP
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHEECCCCEEEEECH
SVIRSATGESVTKEEIGGAQLHAEVTGLAHFNCDGREQAVALVRELLGYLPQNNASPTPR
HHHHHCCCCCCCHHHCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCC
VDRGDTGPRRTPRLERLIPAHQNEPYDVLDVVAEIADNNEFLEIQAQYAPNLVTGFARFG
CCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCHHHHHHHHHC
GRTVGVLASQPLQRAGCLDVDSSLKGARFVRLCDSFDIPLLTLLDVPGYLPGREQETRGI
CCEEEEHHCCCHHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHCCH
IGAGAKLLHAYCEASVPKLAIVLRKAYGGAYPTLANWSATDFTFALEQAEIAVMGPQGAV
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCEEEEECCCCCE
DIIFRRELAAAADPASLREKLLDDYRAAHANASYSAKKGYVDGLLAAAEVRNAVLSHLQL
EHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LADKVGGTPARRHSNIPL
HHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TTVQASFSATGTPRRDSAVWQAIEWLVDSGSFYQLDALSEHDCQHFGTAGRKVPGDGLV
CEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCCCCCCCEE
TGHGRIDGRPVLVYAHDRDFLGGSSSRVHAVRIGKLLDMALQLGLPVIGLNDSSGIRIHE
ECCCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEECCCCCEEEEC
GVDAGAQFSEVFHKTVKASGVVPQISVILGDCAGGAAYAPALTDFIVMAGAESTMFLTGP
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHEECCCCEEEEECH
SVIRSATGESVTKEEIGGAQLHAEVTGLAHFNCDGREQAVALVRELLGYLPQNNASPTPR
HHHHHCCCCCCCHHHCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCC
VDRGDTGPRRTPRLERLIPAHQNEPYDVLDVVAEIADNNEFLEIQAQYAPNLVTGFARFG
CCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCHHHHHHHHHC
GRTVGVLASQPLQRAGCLDVDSSLKGARFVRLCDSFDIPLLTLLDVPGYLPGREQETRGI
CCEEEEHHCCCHHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHCCH
IGAGAKLLHAYCEASVPKLAIVLRKAYGGAYPTLANWSATDFTFALEQAEIAVMGPQGAV
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCEEEEECCCCCE
DIIFRRELAAAADPASLREKLLDDYRAAHANASYSAKKGYVDGLLAAAEVRNAVLSHLQL
EHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LADKVGGTPARRHSNIPL
HHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]