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The map label for this gene is panC

Identifier: 34497091

GI number: 34497091

Start: 1773603

End: 1774436

Strand: Direct

Name: panC

Synonym: CV_1636

Alternate gene names: 34497091

Gene position: 1773603-1774436 (Clockwise)

Preceding gene: 34497090

Following gene: 34497092

Centisome position: 37.33

GC content: 67.39

Gene sequence:

>834_bases
ATGGAAATCATCCGTACCGTGGCCGAGATGCGCGCCTGGCGCAAGCAGGCCGGCAAGCTGGCTTTCGTGCCCACCATGGG
CAATCTGCACGAGGGGCACCTGAAGCTGGTGGCCGCCGCGCGCGAACGCGCCGAGAAAGTCGTGGTCAGCATCTTCGTCA
ACCGGCTGCAGTTCGGCCAGGGCGAGGACTTCGACGCTTACCCGCGCACTTTCGACGCCGACTGCGCCAAGCTGGCCGCC
GCCGGCGTGGACGCGCTGTTCTTCCCGTCCGAACGCGAGCTGTACCCGCGCGTGCGGCAGGATTTCAACGTCGAGCCGCC
GCACATCCAGAACGAGCTGTGCGGCGCCTTCCGCCCCGGGCATTTCCGCGGTGTGGCCACCGTGGTCACCAAGCTGTTCA
ACATCGTGCAGCCCGATCTGGCCTGTTTCGGCAAGAAGGACTACCAGCAGCTGCACGTGATCCAGGCCATGATCGCCGAC
CTGAACTCGCCGATCGAGATCGTGCCGGTGGACACCGGCCGCGCCGGCGACGGCCTGGCGCTGTCGTCGCGCAACGGCTA
CCTGTCGGCCGAAGAGCGCGCCGAAGCGCCGCGCCTGTACCGCAACCTGTCCATGATCCGCGACGGACTGATGGCGGGCA
GCCAGGATTACGCGGCGCTGGAGCAAGCCGCGCGCGACGATCTGGCCGCAGCGGGCTGGACCGTGGACTACGTGGAAGTG
CGGCAGGCCGATACGCTGGAGATCGCCCACGCCGGCGAGAAGCGCCTGGTGGTGCTGGCCGCCGCTCGCTTGGGCAAGAC
CCGTCTGATCGACAATATCGAAGTGTTCCGCTAG

Upstream 100 bases:

>100_bases
GGCAGCATCCAGGGCGCTGTCCAGGCTTACATCAAGGCGGTGAAGGACAAGACCTTCCCGGCCGAAGAGCACACTTACTA
AGCCCGGAAGAGAACGAGAG

Downstream 100 bases:

>100_bases
GCCGGGACGAGAAGGAAGGCTGTCATGCAACGCAATATGCTCAAGTCCAAGCTCCACCGCGTGACCACCACGCATGCCGA
GCTGCATTACATCGGCTCCT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEIIRTVAEMRAWRKQAGKLAFVPTMGNLHEGHLKLVAAARERAEKVVVSIFVNRLQFGQGEDFDAYPRTFDADCAKLAA
AGVDALFFPSERELYPRVRQDFNVEPPHIQNELCGAFRPGHFRGVATVVTKLFNIVQPDLACFGKKDYQQLHVIQAMIAD
LNSPIEIVPVDTGRAGDGLALSSRNGYLSAEERAEAPRLYRNLSMIRDGLMAGSQDYAALEQAARDDLAAAGWTVDYVEV
RQADTLEIAHAGEKRLVVLAAARLGKTRLIDNIEVFR

Sequences:

>Translated_277_residues
MEIIRTVAEMRAWRKQAGKLAFVPTMGNLHEGHLKLVAAARERAEKVVVSIFVNRLQFGQGEDFDAYPRTFDADCAKLAA
AGVDALFFPSERELYPRVRQDFNVEPPHIQNELCGAFRPGHFRGVATVVTKLFNIVQPDLACFGKKDYQQLHVIQAMIAD
LNSPIEIVPVDTGRAGDGLALSSRNGYLSAEERAEAPRLYRNLSMIRDGLMAGSQDYAALEQAARDDLAAAGWTVDYVEV
RQADTLEIAHAGEKRLVVLAAARLGKTRLIDNIEVFR
>Mature_277_residues
MEIIRTVAEMRAWRKQAGKLAFVPTMGNLHEGHLKLVAAARERAEKVVVSIFVNRLQFGQGEDFDAYPRTFDADCAKLAA
AGVDALFFPSERELYPRVRQDFNVEPPHIQNELCGAFRPGHFRGVATVVTKLFNIVQPDLACFGKKDYQQLHVIQAMIAD
LNSPIEIVPVDTGRAGDGLALSSRNGYLSAEERAEAPRLYRNLSMIRDGLMAGSQDYAALEQAARDDLAAAGWTVDYVEV
RQADTLEIAHAGEKRLVVLAAARLGKTRLIDNIEVFR

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=277, Percent_Identity=51.6245487364621, Blast_Score=268, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6322046, Length=311, Percent_Identity=36.0128617363344, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_CHRVO (Q7NXJ0)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901306.1
- ProteinModelPortal:   Q7NXJ0
- SMR:   Q7NXJ0
- GeneID:   2550469
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1636
- NMPDR:   fig|243365.1.peg.1636
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q7NXJ0
- ProtClustDB:   PRK00380
- BioCyc:   CVIO243365:CV_1636-MONOMER
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30709; Mature: 30709

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 150-150 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIRTVAEMRAWRKQAGKLAFVPTMGNLHEGHLKLVAAARERAEKVVVSIFVNRLQFGQ
CHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GEDFDAYPRTFDADCAKLAAAGVDALFFPSERELYPRVRQDFNVEPPHIQNELCGAFRPG
CCCCCCCCCCCCHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
HFRGVATVVTKLFNIVQPDLACFGKKDYQQLHVIQAMIADLNSPIEIVPVDTGRAGDGLA
CHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEE
LSSRNGYLSAEERAEAPRLYRNLSMIRDGLMAGSQDYAALEQAARDDLAAAGWTVDYVEV
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEHEEC
RQADTLEIAHAGEKRLVVLAAARLGKTRLIDNIEVFR
CCCCCEEEECCCCCEEEEEEHHHCCCHHHHCCHHHCC
>Mature Secondary Structure
MEIIRTVAEMRAWRKQAGKLAFVPTMGNLHEGHLKLVAAARERAEKVVVSIFVNRLQFGQ
CHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GEDFDAYPRTFDADCAKLAAAGVDALFFPSERELYPRVRQDFNVEPPHIQNELCGAFRPG
CCCCCCCCCCCCHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
HFRGVATVVTKLFNIVQPDLACFGKKDYQQLHVIQAMIADLNSPIEIVPVDTGRAGDGLA
CHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEE
LSSRNGYLSAEERAEAPRLYRNLSMIRDGLMAGSQDYAALEQAARDDLAAAGWTVDYVEV
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEHEEC
RQADTLEIAHAGEKRLVVLAAARLGKTRLIDNIEVFR
CCCCCEEEECCCCCEEEEEEHHHCCCHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782