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The map label for this gene is fsr [H]

Identifier: 34496253

GI number: 34496253

Start: 821561

End: 822760

Strand: Reverse

Name: fsr [H]

Synonym: CV_0798

Alternate gene names: 34496253

Gene position: 822760-821561 (Counterclockwise)

Preceding gene: 34496255

Following gene: 34496252

Centisome position: 17.32

GC content: 67.33

Gene sequence:

>1200_bases
ATGACTACCAGCAGTCCCACACTCGCCGCCGCGCAGGACACCCGCTTCCGCGTGCTCGGCGCGATCAGTTTTTCCCATTT
TCTCAACGACATGCTGCAGTCGCTGCTGGTGGCGCTGTACCCGCTGCTGAAGGGCAACTACCACCTCAGCTTCGCCGAGA
TCGGCCTGATGACCTTCACCTACCAGTGCACCGCGTCGCTGCTGCAGCCGCTGGTGGGCATCTATACCGACAAGCGGCCT
CAGCCCTATTCGCTGGTATTCGGCATGGGTTCGACGCTGATCGGCCTGCTGCTGCTGTCCGGCGCCACCAGCTTCCCGCT
GCTGCTGCTGGCCGCCGCGCTGGTGGGCACCGGTTCGTCCATTTTCCACCCGGAATCGTCGCGCGTGGCGCGGATGGCGT
CGGGCGGCCGCCCCGGCCTCGCCCAGTCGATCTTCCAGGTCGGCGGCAACGCCGGCAGCGCCACCGGTCCCTTGCTGGCG
GCGCTGATCGTGATCCCGCTGGGCCAGCGCAGCGTGGCCTGGTTCGGTCTGGCCGCGCTGCTGGCGATGTACGTGCTGTT
CCGCGTCGGCCAGTGGTACGCGCACCAGCAGCGCCAGGCGAAGAAAGCCAGCGCGGCCGTCCCGCCCGACCTGTCCTCGG
CCCGGGTCAGGCTGACGCTGCTGCTGTTGCTGCTGCTGGTGTTCTCCAAGCACTTTTACCTCGCCAGCATCACCAGCTAC
TACACCTTCTACCTGATCCACCACTTCCAGGTGGGCGTGCAGTCGGCGCAGCTGTACCTGTTCCTGTTCCTGTTCGCGGT
GGCCGCCGGCACCGTGCTGGGCGGCCCGATCGGCGACGCCATCGGCCGCAAGCGGGTGATAGGCTTCTCCATCTTGGGCG
TGGCGCCGCTGGCGCTGGCGCTGCCGCACGCCAACCTGTTCTGGACCGCGGCGCTGTCGTTGCCCATCGGCTTCATCCTG
GCCTCGGCTTTCCCAGCCATCCTGATCTATGCGCAGGAGCTGCTGCCGGGCAAGGTGGGCATGGTGTCCGGCATGTTCTT
CGGCTTCGCCTTCGGCATCGGCGGCATCGGCGCCGCGGTGCTGGGCGAACTGGCGGACCTCAGGGGCATCGAATTCGTCT
ACCAGTTGTGCGCCTTCCTGCCGCTGCTGGGCATCGCGGCGGTGGCGCTGCCGGATCTGCATCGCAAGGCCAGGGTTTGA

Upstream 100 bases:

>100_bases
CCACTCTGCCTCTTTCGATAAGATGATTGCCTCATTTTCGCAGGACTGGCGGAAACGTGCTTGCTAGCATGGTCCTACCA
CCCAGAATGAGTATCGCACG

Downstream 100 bases:

>100_bases
CACCGTCCGGCGGCGCGCCGGATACTGCGCGGCATTGAAACCCAAGCGGGACGCCGGGCACAGGCTGGCGTTCCGCGCAT
TCGGAAGCGCAGTCATCATG

Product: major facilitator superfamily fosmidomycin resistance protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTTSSPTLAAAQDTRFRVLGAISFSHFLNDMLQSLLVALYPLLKGNYHLSFAEIGLMTFTYQCTASLLQPLVGIYTDKRP
QPYSLVFGMGSTLIGLLLLSGATSFPLLLLAAALVGTGSSIFHPESSRVARMASGGRPGLAQSIFQVGGNAGSATGPLLA
ALIVIPLGQRSVAWFGLAALLAMYVLFRVGQWYAHQQRQAKKASAAVPPDLSSARVRLTLLLLLLLVFSKHFYLASITSY
YTFYLIHHFQVGVQSAQLYLFLFLFAVAAGTVLGGPIGDAIGRKRVIGFSILGVAPLALALPHANLFWTAALSLPIGFIL
ASAFPAILIYAQELLPGKVGMVSGMFFGFAFGIGGIGAAVLGELADLRGIEFVYQLCAFLPLLGIAAVALPDLHRKARV

Sequences:

>Translated_399_residues
MTTSSPTLAAAQDTRFRVLGAISFSHFLNDMLQSLLVALYPLLKGNYHLSFAEIGLMTFTYQCTASLLQPLVGIYTDKRP
QPYSLVFGMGSTLIGLLLLSGATSFPLLLLAAALVGTGSSIFHPESSRVARMASGGRPGLAQSIFQVGGNAGSATGPLLA
ALIVIPLGQRSVAWFGLAALLAMYVLFRVGQWYAHQQRQAKKASAAVPPDLSSARVRLTLLLLLLLVFSKHFYLASITSY
YTFYLIHHFQVGVQSAQLYLFLFLFAVAAGTVLGGPIGDAIGRKRVIGFSILGVAPLALALPHANLFWTAALSLPIGFIL
ASAFPAILIYAQELLPGKVGMVSGMFFGFAFGIGGIGAAVLGELADLRGIEFVYQLCAFLPLLGIAAVALPDLHRKARV
>Mature_398_residues
TTSSPTLAAAQDTRFRVLGAISFSHFLNDMLQSLLVALYPLLKGNYHLSFAEIGLMTFTYQCTASLLQPLVGIYTDKRPQ
PYSLVFGMGSTLIGLLLLSGATSFPLLLLAAALVGTGSSIFHPESSRVARMASGGRPGLAQSIFQVGGNAGSATGPLLAA
LIVIPLGQRSVAWFGLAALLAMYVLFRVGQWYAHQQRQAKKASAAVPPDLSSARVRLTLLLLLLLVFSKHFYLASITSYY
TFYLIHHFQVGVQSAQLYLFLFLFAVAAGTVLGGPIGDAIGRKRVIGFSILGVAPLALALPHANLFWTAALSLPIGFILA
SAFPAILIYAQELLPGKVGMVSGMFFGFAFGIGGIGAAVLGELADLRGIEFVYQLCAFLPLLGIAAVALPDLHRKARV

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=384, Percent_Identity=63.8020833333333, Blast_Score=441, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42394; Mature: 42263

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSSPTLAAAQDTRFRVLGAISFSHFLNDMLQSLLVALYPLLKGNYHLSFAEIGLMTFT
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
YQCTASLLQPLVGIYTDKRPQPYSLVFGMGSTLIGLLLLSGATSFPLLLLAAALVGTGSS
HHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
IFHPESSRVARMASGGRPGLAQSIFQVGGNAGSATGPLLAALIVIPLGQRSVAWFGLAAL
CCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
LAMYVLFRVGQWYAHQQRQAKKASAAVPPDLSSARVRLTLLLLLLLVFSKHFYLASITSY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
YTFYLIHHFQVGVQSAQLYLFLFLFAVAAGTVLGGPIGDAIGRKRVIGFSILGVAPLALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHH
LPHANLFWTAALSLPIGFILASAFPAILIYAQELLPGKVGMVSGMFFGFAFGIGGIGAAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LGELADLRGIEFVYQLCAFLPLLGIAAVALPDLHRKARV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTSSPTLAAAQDTRFRVLGAISFSHFLNDMLQSLLVALYPLLKGNYHLSFAEIGLMTFT
CCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
YQCTASLLQPLVGIYTDKRPQPYSLVFGMGSTLIGLLLLSGATSFPLLLLAAALVGTGSS
HHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
IFHPESSRVARMASGGRPGLAQSIFQVGGNAGSATGPLLAALIVIPLGQRSVAWFGLAAL
CCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
LAMYVLFRVGQWYAHQQRQAKKASAAVPPDLSSARVRLTLLLLLLLVFSKHFYLASITSY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
YTFYLIHHFQVGVQSAQLYLFLFLFAVAAGTVLGGPIGDAIGRKRVIGFSILGVAPLALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHH
LPHANLFWTAALSLPIGFILASAFPAILIYAQELLPGKVGMVSGMFFGFAFGIGGIGAAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LGELADLRGIEFVYQLCAFLPLLGIAAVALPDLHRKARV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]