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The map label for this gene is cysG [H]

Identifier: 339905977

GI number: 339905977

Start: 3214667

End: 3215443

Strand: Reverse

Name: cysG [H]

Synonym: NA

Alternate gene names: 339905977

Gene position: 3215443-3214667 (Counterclockwise)

Preceding gene: 238028374

Following gene: 238028369

Centisome position: 82.31

GC content: 74.65

Gene sequence:

>777_bases
ATGGGCAAGGTGTATCTGATTGGCGCGGGGCCGGGCGCAGCGGACCTGATCACGGTGCGCGGCGCGCGGCTGCTCGGCCT
GGCCGACGTGGTGCTGCACGACGCGCTGGTGGAGCCGGCGATGCTCGAGCATGCGCCGCACGCGCGGCTCGTCCCGGTCG
GCAAGCGCTGCGGGCAGCGCTCCTCCGCGCAGCAGTTCATCAACAAGCAGATTGTCGACGCCGCGCGCGAGCATGCCGTG
GTGGTGCGCCTGAAGGGCGGCGACCCGATGCTGTTCGGCCGCGCCGACGAGGAAATGCGCGCGCTGGAGGCGGCCGGGAT
CGACTACGAGGTGGTGCCGGGCATCACCGCGGCGCTGGCCGGCGCGGCCACGCTCAAGCGCTCGCTGACGCTGCGCGGCG
TCGCGCGCAGCGTCGCGTTTGCCACCCGGAGCCGCGCGCCGGGCAGCGACGAGATCCGCGAGCAGGTCAACGCCGATTCG
CTGGTGTTCTACATGGGCCGCGACAGCGCGCCGGGCATCGCGCGGCAATTGATCGACGCGGGCCGCGCGGCCGACACGCC
GGTGGCGATCGTCGAGGCCTGCAGCACGGCTCGCGAGCGCACGCTCGAGCTGACGCTGGCACGGATGGCGGCGGGCGAGG
CGCAGGCCTGGCTCGATCCCGCGCAGCCGAGCCTGCTGATGATCGGCGCCGCGTTCGGCGAGCGCGGGCGGCTCGCGGAC
GACGGCGCGCCGGCCGAGGCGGGCACGGACGGCGACGGCATGCGCAACGCGGCCTGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: Uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:
NA

Sequences:

>Translated_258_residues
MGKVYLIGAGPGAADLITVRGARLLGLADVVLHDALVEPAMLEHAPHARLVPVGKRCGQRSSAQQFINKQIVDAAREHAV
VVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALAGAATLKRSLTLRGVARSVAFATRSRAPGSDEIREQVNADS
LVFYMGRDSAPGIARQLIDAGRAADTPVAIVEACSTARERTLELTLARMAAGEAQAWLDPAQPSLLMIGAAFGERGRLAD
DGAPAEAGTDGDGMRNAA
>Mature_257_residues
GKVYLIGAGPGAADLITVRGARLLGLADVVLHDALVEPAMLEHAPHARLVPVGKRCGQRSSAQQFINKQIVDAAREHAVV
VRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALAGAATLKRSLTLRGVARSVAFATRSRAPGSDEIREQVNADSL
VFYMGRDSAPGIARQLIDAGRAADTPVAIVEACSTARERTLELTLARMAAGEAQAWLDPAQPSLLMIGAAFGERGRLADD
GAPAEAGTDGDGMRNAA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=240, Percent_Identity=40.4166666666667, Blast_Score=143, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322922, Length=233, Percent_Identity=30.4721030042918, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 26912; Mature: 26781

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYLIGAGPGAADLITVRGARLLGLADVVLHDALVEPAMLEHAPHARLVPVGKRCGQR
CCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEEECHHHCCCH
SSAQQFINKQIVDAAREHAVVVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALA
HHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCHHHHHHHHCCCCEEECCCHHHHHH
GAATLKRSLTLRGVARSVAFATRSRAPGSDEIREQVNADSLVFYMGRDSAPGIARQLIDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHC
GRAADTPVAIVEACSTARERTLELTLARMAAGEAQAWLDPAQPSLLMIGAAFGERGRLAD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECCCCCCCCCC
DGAPAEAGTDGDGMRNAA
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKVYLIGAGPGAADLITVRGARLLGLADVVLHDALVEPAMLEHAPHARLVPVGKRCGQR
CEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEEECHHHCCCH
SSAQQFINKQIVDAAREHAVVVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALA
HHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCHHHHHHHHCCCCEEECCCHHHHHH
GAATLKRSLTLRGVARSVAFATRSRAPGSDEIREQVNADSLVFYMGRDSAPGIARQLIDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHC
GRAADTPVAIVEACSTARERTLELTLARMAAGEAQAWLDPAQPSLLMIGAAFGERGRLAD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECCCCCCCCCC
DGAPAEAGTDGDGMRNAA
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA