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The map label for this gene is pepA [H]

Identifier: 238028369

GI number: 238028369

Start: 3210313

End: 3211824

Strand: Reverse

Name: pepA [H]

Synonym: bglu_1g28300

Alternate gene names: 238028369

Gene position: 3211824-3210313 (Counterclockwise)

Preceding gene: 339905977

Following gene: 238028368

Centisome position: 82.22

GC content: 68.19

Gene sequence:

>1512_bases
ATGGACTTTAGCATAAAAGGCTTTGATTGGAGCAAAGGTGCTGCCAAGGGGTTCCTGACCGGAAAATCCGACTGCGTCGT
GATCGGCGTGTTCGAATCCCAAACGCTGTCCGGCGCCGCGCTCGACACGGATGAAGCCACCAAGGGGCTGCTGTCGCGGA
TCATCAAGGCCGGCGACATGGACGGCAAGGCCGGCAAGACCCTGCTGCTGCACGAAGTGTCGGGCATCGGCGCCTCGCGC
GTGCTGCTCGTCGGCCTCGGCAAGCAGGACGGCTTCGGCCAGAAGGCTTACCAGGAGGCCGTCCGCGCCGCCTGGCGCGC
GCTGCTCGCGACCAAGGTCGGGCAGGTCGCGTTCACGCTCACGCAGTTGCCCGTCGCCGAGCGCGCGTCCGACTGGTGCG
TGCGTGCCGCGATTCTCGCGCTGCGCAACGAAACCTACCGCTTCACGCAGATGAAGAGCAAGGCCGAGCCCGAGCCGGCC
ACGCTCAAGCGCGTCGTGTTCAGCGTCGATCCGGCCGAGGAGAAGGCCGCCAAGCTGGCCGTGAAGCAGGCCGTGGCGAT
CGCCAACGGCATCGATTTCACGCGCGATCTCGGCAACCTGCCCGCCAACGTCTGCACGCCCACCTATCTTGCGAACTCGG
CCCGGCAGATGGCTAAGGACTGGAATCTCAGGTCCGAGGTGCTCGGCCTGAAGCAGATCCAGGCGCTGAAGATGGAGTCG
TTCCTGGCGGTCGCGCGCGGCTCGGTCGAGCCGCCGCAGTTCATCGTGCTGCACTACCAGGGCGGGCCGGCCAAGGCGGC
GCCGATCGTGCTGGTCGGCAAGGGCATCACGTTCGACACGGGCGGCATCTCGCTGAAGCCGGGCGAGGGCATGGACGAGA
TGAAGTACGACATGTGCGGCGCCGGCTCGGTGCTCGGCACGATGCGCGCCGTGGCCGAAATGGGGCTCAAGCTCAACGTC
GTCGCGATCGTGCCGACCTGCGAGAACATGCCGGCGGGCAACGCGCTGAAGCCGGGCGACATCGTCACGAGCATGAAGGG
GCTGACGATCGAGGTGCTCAATACCGACGCCGAGGGCCGCCTGATCCTCTGCGACGCGCTCACCTACGCCGAGCGCTTCA
AGCCGGCCGCCGTGATCGACGTCGCGACGCTGACGGGCGCCTGCGTCGTCGCGCTCGGCCACCACCACAGCGGCCTGTTC
TCGAAGGACGACGCGCTGGCGGGCGAGCTGCTCGACGCCTCGCGCGAGGCCGGCGATCCGGCCTGGCGTCTGCCGCTCGA
CGACGAGTATCAGGAGCAGCTGAAGTCGAATTTCGCCGACCTGACGAATCTCGGCGGGCGTCCGGGCGGCAGCGTGACGG
CGGCGTGCTTCCTGTCGCGTTTCGCCGAGGCTTACCCATGGGCGCACCTCGACATCGCCGGCACCGCCTGGAAGAGCGGC
GCGGCGAAGGGGGCCACCGGCCGGCCGGTGCCGCTCCTGACGCAGTTCCTGATCGACCGCGCCGGCGCGTGA

Upstream 100 bases:

>100_bases
GAAGAGGGCGGGAGGGGGTGGGGCGCGCGCCGCCAGGGAAAAAATAGCGGATAATTGCGGCTTTCACCCTTAGCCCAGAT
TTTATCCGAGGACAAGCGCG

Downstream 100 bases:

>100_bases
GCGGCGCGGCGACGACGCAGCGGTGCGCGTGATGACGCGGATCGATTTCCACTCGAACGTCGGCGATTCGCTGGCGTATG
CGTGCCGGCTGCTGCGCAAG

Product: multifunctional aminopeptidase A

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MDFSIKGFDWSKGAAKGFLTGKSDCVVIGVFESQTLSGAALDTDEATKGLLSRIIKAGDMDGKAGKTLLLHEVSGIGASR
VLLVGLGKQDGFGQKAYQEAVRAAWRALLATKVGQVAFTLTQLPVAERASDWCVRAAILALRNETYRFTQMKSKAEPEPA
TLKRVVFSVDPAEEKAAKLAVKQAVAIANGIDFTRDLGNLPANVCTPTYLANSARQMAKDWNLRSEVLGLKQIQALKMES
FLAVARGSVEPPQFIVLHYQGGPAKAAPIVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKLNV
VAIVPTCENMPAGNALKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVVALGHHHSGLF
SKDDALAGELLDASREAGDPAWRLPLDDEYQEQLKSNFADLTNLGGRPGGSVTAACFLSRFAEAYPWAHLDIAGTAWKSG
AAKGATGRPVPLLTQFLIDRAGA

Sequences:

>Translated_503_residues
MDFSIKGFDWSKGAAKGFLTGKSDCVVIGVFESQTLSGAALDTDEATKGLLSRIIKAGDMDGKAGKTLLLHEVSGIGASR
VLLVGLGKQDGFGQKAYQEAVRAAWRALLATKVGQVAFTLTQLPVAERASDWCVRAAILALRNETYRFTQMKSKAEPEPA
TLKRVVFSVDPAEEKAAKLAVKQAVAIANGIDFTRDLGNLPANVCTPTYLANSARQMAKDWNLRSEVLGLKQIQALKMES
FLAVARGSVEPPQFIVLHYQGGPAKAAPIVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKLNV
VAIVPTCENMPAGNALKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVVALGHHHSGLF
SKDDALAGELLDASREAGDPAWRLPLDDEYQEQLKSNFADLTNLGGRPGGSVTAACFLSRFAEAYPWAHLDIAGTAWKSG
AAKGATGRPVPLLTQFLIDRAGA
>Mature_503_residues
MDFSIKGFDWSKGAAKGFLTGKSDCVVIGVFESQTLSGAALDTDEATKGLLSRIIKAGDMDGKAGKTLLLHEVSGIGASR
VLLVGLGKQDGFGQKAYQEAVRAAWRALLATKVGQVAFTLTQLPVAERASDWCVRAAILALRNETYRFTQMKSKAEPEPA
TLKRVVFSVDPAEEKAAKLAVKQAVAIANGIDFTRDLGNLPANVCTPTYLANSARQMAKDWNLRSEVLGLKQIQALKMES
FLAVARGSVEPPQFIVLHYQGGPAKAAPIVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKLNV
VAIVPTCENMPAGNALKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVVALGHHHSGLF
SKDDALAGELLDASREAGDPAWRLPLDDEYQEQLKSNFADLTNLGGRPGGSVTAACFLSRFAEAYPWAHLDIAGTAWKSG
AAKGATGRPVPLLTQFLIDRAGA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=495, Percent_Identity=36.969696969697, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI47155554, Length=313, Percent_Identity=32.2683706070287, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1790710, Length=507, Percent_Identity=51.4792899408284, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI87082123, Length=351, Percent_Identity=39.6011396011396, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17556903, Length=312, Percent_Identity=34.2948717948718, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=460, Percent_Identity=26.7391304347826, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20129969, Length=523, Percent_Identity=31.5487571701721, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24662227, Length=509, Percent_Identity=30.2554027504912, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21355725, Length=313, Percent_Identity=37.6996805111821, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24661038, Length=313, Percent_Identity=37.3801916932907, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI161077148, Length=499, Percent_Identity=31.4629258517034, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI20130057, Length=499, Percent_Identity=31.4629258517034, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI21355645, Length=495, Percent_Identity=30.1010101010101, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24662223, Length=495, Percent_Identity=30.1010101010101, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI20129963, Length=499, Percent_Identity=29.0581162324649, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI19922386, Length=323, Percent_Identity=33.7461300309598, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21357381, Length=312, Percent_Identity=32.6923076923077, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379063, Length=312, Percent_Identity=32.6923076923077, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379062, Length=312, Percent_Identity=32.6923076923077, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646701, Length=316, Percent_Identity=27.2151898734177, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24646703, Length=316, Percent_Identity=27.2151898734177, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21358201, Length=316, Percent_Identity=27.2151898734177, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53182; Mature: 53182

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSIKGFDWSKGAAKGFLTGKSDCVVIGVFESQTLSGAALDTDEATKGLLSRIIKAGDM
CCCCCCCCCCCCCCCCCEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCC
DGKAGKTLLLHEVSGIGASRVLLVGLGKQDGFGQKAYQEAVRAAWRALLATKVGQVAFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQLPVAERASDWCVRAAILALRNETYRFTQMKSKAEPEPATLKRVVFSVDPAEEKAAKLA
HHCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCCCHHHHHHHHEECCCHHHHHHHHH
VKQAVAIANGIDFTRDLGNLPANVCTPTYLANSARQMAKDWNLRSEVLGLKQIQALKMES
HHHHHHHHCCCHHHHHHCCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FLAVARGSVEPPQFIVLHYQGGPAKAAPIVLVGKGITFDTGGISLKPGEGMDEMKYDMCG
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTMRAVAEMGLKLNVVAIVPTCENMPAGNALKPGDIVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDVATLTGACVVALGHHHSGLFSKDDALAGELLDASREAGDP
EEEEEHHHHHHHCCCCCEEEHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC
AWRLPLDDEYQEQLKSNFADLTNLGGRPGGSVTAACFLSRFAEAYPWAHLDIAGTAWKSG
EEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
AAKGATGRPVPLLTQFLIDRAGA
CCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFSIKGFDWSKGAAKGFLTGKSDCVVIGVFESQTLSGAALDTDEATKGLLSRIIKAGDM
CCCCCCCCCCCCCCCCCEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCC
DGKAGKTLLLHEVSGIGASRVLLVGLGKQDGFGQKAYQEAVRAAWRALLATKVGQVAFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQLPVAERASDWCVRAAILALRNETYRFTQMKSKAEPEPATLKRVVFSVDPAEEKAAKLA
HHCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCCCHHHHHHHHEECCCHHHHHHHHH
VKQAVAIANGIDFTRDLGNLPANVCTPTYLANSARQMAKDWNLRSEVLGLKQIQALKMES
HHHHHHHHCCCHHHHHHCCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FLAVARGSVEPPQFIVLHYQGGPAKAAPIVLVGKGITFDTGGISLKPGEGMDEMKYDMCG
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTMRAVAEMGLKLNVVAIVPTCENMPAGNALKPGDIVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDVATLTGACVVALGHHHSGLFSKDDALAGELLDASREAGDP
EEEEEHHHHHHHCCCCCEEEHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC
AWRLPLDDEYQEQLKSNFADLTNLGGRPGGSVTAACFLSRFAEAYPWAHLDIAGTAWKSG
EEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
AAKGATGRPVPLLTQFLIDRAGA
CCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA