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The map label for this gene is clpP2

Identifier: 33862335

GI number: 33862335

Start: 63057

End: 63731

Strand: Reverse

Name: clpP2

Synonym: PMT0062

Alternate gene names: 33862335

Gene position: 63731-63057 (Counterclockwise)

Preceding gene: 33862336

Following gene: 33862334

Centisome position: 2.64

GC content: 54.22

Gene sequence:

>675_bases
GTGATCGATTCCTACTGCTACCACCCCATCCACAATCGCTGGCAAGGCATTCGTCCTGTCTCATCACCAGGGATCCTGCC
CACAGTGGTGGAACAGTCGGGCCGTGGGGAACGGGCATTCGACATTTACTCGCGCTTGCTACGTGAGCGAATCATTTTTC
TTGGCACTGGTGTCGACGATCAAGTAGCAGATGCCCTCGTTGCTCAGATGCTCTTCCTTGAAGCCGAAGATCCCGAAAAG
GACATCCAGATCTATATCAACTCCCCAGGTGGTTCAGTGACCGCTGGTTTGGCTATCTATGACACCATGCAGCAGGTCGC
TCCAGACGTCGTGACCATCTGTTATGGCCTTGCTGCCAGCATGGGGGCTTTCCTTCTCTGCGGAGGTACCAAAGGCAAGC
GACTGGCACTACCCAATGCACGGATCATGATTCATCAGCCCCTGGGTGGTGCCCAGGGCCAAGCAGTAGACATCGAAATC
CAGGCTAAAGAGATCCTCTTCTTAAAAGAAACCCTCAACGGCCTTCTCGCCGAGCACACTGGCCAACCCCTCAACAAAAT
CGCTGAAGACACTGACCGCGACCACTTCCTTTCTCCAGCAAAAGCGGTTGAATACGGACTGATCGATCGGGTTGTGGATA
GCCTCACAGGCGGTGGAATCGTTAAGGAAGGGTGA

Upstream 100 bases:

>100_bases
AAGACCAACAAAGCCAACACTGAAAAACCTGCCTCGGACAAAAGCAAGTCCTGAATGGCACCAATAGATTGATAGAAGTG
CTCCCCTAAAGCCCAAGCGA

Downstream 100 bases:

>100_bases
CGCAACCCTGATCTGACACGATCCTGAGCGTTCAGGCTGGCCAACATTCGTCAGATCCTGTCTGCCCGTTTGAAGTGATC
ACAGCCCGATGGCCAAATTC

Product: Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MIDSYCYHPIHNRWQGIRPVSSPGILPTVVEQSGRGERAFDIYSRLLRERIIFLGTGVDDQVADALVAQMLFLEAEDPEK
DIQIYINSPGGSVTAGLAIYDTMQQVAPDVVTICYGLAASMGAFLLCGGTKGKRLALPNARIMIHQPLGGAQGQAVDIEI
QAKEILFLKETLNGLLAEHTGQPLNKIAEDTDRDHFLSPAKAVEYGLIDRVVDSLTGGGIVKEG

Sequences:

>Translated_224_residues
MIDSYCYHPIHNRWQGIRPVSSPGILPTVVEQSGRGERAFDIYSRLLRERIIFLGTGVDDQVADALVAQMLFLEAEDPEK
DIQIYINSPGGSVTAGLAIYDTMQQVAPDVVTICYGLAASMGAFLLCGGTKGKRLALPNARIMIHQPLGGAQGQAVDIEI
QAKEILFLKETLNGLLAEHTGQPLNKIAEDTDRDHFLSPAKAVEYGLIDRVVDSLTGGGIVKEG
>Mature_224_residues
MIDSYCYHPIHNRWQGIRPVSSPGILPTVVEQSGRGERAFDIYSRLLRERIIFLGTGVDDQVADALVAQMLFLEAEDPEK
DIQIYINSPGGSVTAGLAIYDTMQQVAPDVVTICYGLAASMGAFLLCGGTKGKRLALPNARIMIHQPLGGAQGQAVDIEI
QAKEILFLKETLNGLLAEHTGQPLNKIAEDTDRDHFLSPAKAVEYGLIDRVVDSLTGGGIVKEG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=57.4468085106383, Blast_Score=224, Evalue=7e-59,
Organism=Escherichia coli, GI1786641, Length=201, Percent_Identity=63.18407960199, Blast_Score=266, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=55.3763440860215, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=53.0927835051546, Blast_Score=214, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_PROMM (Q7V992)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_893895.1
- ProteinModelPortal:   Q7V992
- SMR:   Q7V992
- STRING:   Q7V992
- MEROPS:   S14.001
- GeneID:   1729041
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0062
- NMPDR:   fig|74547.1.peg.62
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   CLSK646815
- BioCyc:   PMAR74547:PMT0062-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 24231; Mature: 24231

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 120-120 ACT_SITE 145-145

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSYCYHPIHNRWQGIRPVSSPGILPTVVEQSGRGERAFDIYSRLLRERIIFLGTGVDD
CCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCH
QVADALVAQMLFLEAEDPEKDIQIYINSPGGSVTAGLAIYDTMQQVAPDVVTICYGLAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
MGAFLLCGGTKGKRLALPNARIMIHQPLGGAQGQAVDIEIQAKEILFLKETLNGLLAEHT
HCCEEEECCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHC
GQPLNKIAEDTDRDHFLSPAKAVEYGLIDRVVDSLTGGGIVKEG
CCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure
MIDSYCYHPIHNRWQGIRPVSSPGILPTVVEQSGRGERAFDIYSRLLRERIIFLGTGVDD
CCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCH
QVADALVAQMLFLEAEDPEKDIQIYINSPGGSVTAGLAIYDTMQQVAPDVVTICYGLAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
MGAFLLCGGTKGKRLALPNARIMIHQPLGGAQGQAVDIEIQAKEILFLKETLNGLLAEHT
HCCEEEECCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHC
GQPLNKIAEDTDRDHFLSPAKAVEYGLIDRVVDSLTGGGIVKEG
CCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642