Click here to switch to the map view.

The map label for this gene is murC [H]

Identifier: 33862300

GI number: 33862300

Start: 29255

End: 30721

Strand: Reverse

Name: murC [H]

Synonym: PMT0027

Alternate gene names: 33862300

Gene position: 30721-29255 (Counterclockwise)

Preceding gene: 33862302

Following gene: 33862299

Centisome position: 1.27

GC content: 52.62

Gene sequence:

>1467_bases
TTGAGCCTATGGTTTTGCCCATTGACCAGCACGCTCAACCGCCAGCAACCCATCCACTTCATAGGTGTTGGCGGTATCGG
CATGTCTGCACTAGCTCTAATTCTGGTGAATCGAGGTCATATCGTCTCCGGCTCCGACTCACGAGAAAACACTGCCGTTG
AGCAACTGAGAGCTCAAGGAGTAAGAGTCTTCCGCGATCAGAGCGCCGCAAACATCGATGCCATTTGTAGCAACGTAGAT
CTCCTTCCTTTGGTTGTGATCAGCACAGCCATTCCCAAGAGCAATCCTGAGCTCAAGGCAGCCAAGCTGTCTCAATTGAA
AATCTTGCATCGCTCAGACCTCCTTGCTGCCTTGATTCAGGCACAACCATCTATTGCAGTAGCCGGAAGCCATGGCAAAA
CCACCACCAGCACCCTGCTCACTACACTGCTGGCCACAACCGATCAAGACCCAACAGCTGTGATTGGTGGTGTCGTGCCT
TACTACGACAGCAATGGCCATGTGGGCAAAGGACGACTGCTAGTAGCAGAAGCTGATGAATCTGATGGATCTCTCGTCAA
GTTTCAGGCAACGCTCGGCGTGATCACCAACTTGGAGTTAGATCACACCGACCACTACGCCAATCTTGATGAACTGATCA
ACACCATGAAGCGGTTCGGCCAAGGTTGCCGACGACTGCTGGCGAACTTCGACTGCCCAATCCTCAAAGAGCATTTCGAT
GCCACAGCTTGGTGGTCAGTCAAAACCTCAGCGGGTGTTGATTTTGCAGCTTTACCAATTTGCCTCAATGGCGATCAAAC
AATTGCGGACATTTACGAGCAGGGCAAACGGATGGGGCAAATCACACTGCCAATGCCCGGACTTCACAACCTCAGCAACG
CTATGGCAGCTATCGCAGCCTGCAGACTCGAAGGACTGTCCTTTGAGGACGTGCAACAAGGTCTTGCTGACCTGCAGCCT
CCTGGGCGCCGTTTCGACTTCCGAGGCACCTGGGAGGGTCGCCAAATCGTTGATGATTACGCCCACCATCCAAGCGAAGT
CAGCGCGACACTCACAATGGCGCGCTTGATAGTAACTAGTGGTCGTAGCCAACTACCAAACCCACCCAAACGCATTTTGG
CAGTGTTCCAGCCTCATCGATACAGCCGTACAAACAAATTTCTCTACGACTTCGCAAGGGCACTCGGTGAAGCGGATGCT
GTTCTGCTAGCACCCGTTTACAGCGCCGGAGAGAACCCTATTCAGGGAGCAACGAGTGAGAGCCTGGCTAAAGCGATCAG
AATCCAACACCCCAACCTGCCAGTCGCTGTAGCCGAAAACTTTAATCAGCTAACCCTATTGGTGCAAAAACACAGCCTCA
AAGGTGACCTAGTCCTCGCCATGGGTGCAGGCAATATCAACAATCTATGGAGACAACTGACACATCTTGACAACGCAAAG
AGATGCCCACCCTCCCTGGCAGCCTGA

Upstream 100 bases:

>100_bases
CGGATGAGGAGGCGGCCCATACCTGGCACAAGGTCAACCCCGGCCGGACCTCTCCAAAACATAAGAATGACGGGCTTTTA
GCCCAAGACTGGCTTATCTT

Downstream 100 bases:

>100_bases
CCCTAGTGAAGGGGATCAAGCCCCAACCACTGGTTTCTCTTGCCAACTTCACGAGCTGGCGCGTCGGAGGACCTGCGGAA
TGGTTTGCATCACCCAGCAG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSLWFCPLTSTLNRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDSRENTAVEQLRAQGVRVFRDQSAANIDAICSNVD
LLPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQAQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVP
YYDSNGHVGKGRLLVAEADESDGSLVKFQATLGVITNLELDHTDHYANLDELINTMKRFGQGCRRLLANFDCPILKEHFD
ATAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAACRLEGLSFEDVQQGLADLQP
PGRRFDFRGTWEGRQIVDDYAHHPSEVSATLTMARLIVTSGRSQLPNPPKRILAVFQPHRYSRTNKFLYDFARALGEADA
VLLAPVYSAGENPIQGATSESLAKAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTHLDNAK
RCPPSLAA

Sequences:

>Translated_488_residues
MSLWFCPLTSTLNRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDSRENTAVEQLRAQGVRVFRDQSAANIDAICSNVD
LLPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQAQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVP
YYDSNGHVGKGRLLVAEADESDGSLVKFQATLGVITNLELDHTDHYANLDELINTMKRFGQGCRRLLANFDCPILKEHFD
ATAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAACRLEGLSFEDVQQGLADLQP
PGRRFDFRGTWEGRQIVDDYAHHPSEVSATLTMARLIVTSGRSQLPNPPKRILAVFQPHRYSRTNKFLYDFARALGEADA
VLLAPVYSAGENPIQGATSESLAKAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTHLDNAK
RCPPSLAA
>Mature_487_residues
SLWFCPLTSTLNRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDSRENTAVEQLRAQGVRVFRDQSAANIDAICSNVDL
LPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQAQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVPY
YDSNGHVGKGRLLVAEADESDGSLVKFQATLGVITNLELDHTDHYANLDELINTMKRFGQGCRRLLANFDCPILKEHFDA
TAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAACRLEGLSFEDVQQGLADLQPP
GRRFDFRGTWEGRQIVDDYAHHPSEVSATLTMARLIVTSGRSQLPNPPKRILAVFQPHRYSRTNKFLYDFARALGEADAV
LLAPVYSAGENPIQGATSESLAKAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTHLDNAKR
CPPSLAA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=497, Percent_Identity=34.6076458752515, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1790680, Length=472, Percent_Identity=27.5423728813559, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 52802; Mature: 52671

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLWFCPLTSTLNRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDSRENTAVEQLRAQG
CCEEEECCHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCC
VRVFRDQSAANIDAICSNVDLLPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQ
HHEECCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVPYYDSNGHVGKGRLLVAEADE
CCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEECCCCCCCCCEEEEEECCC
SDGSLVKFQATLGVITNLELDHTDHYANLDELINTMKRFGQGCRRLLANFDCPILKEHFD
CCCCEEEEEEEEEEHEECEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
ATAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAA
CEEEEEEECCCCCCEEEEEEEECCCHHHHHHHHCCHHCCEEECCCCCCHHHHHHHHHHHH
CRLEGLSFEDVQQGLADLQPPGRRFDFRGTWEGRQIVDDYAHHPSEVSATLTMARLIVTS
HHHCCCCHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHC
GRSQLPNPPKRILAVFQPHRYSRTNKFLYDFARALGEADAVLLAPVYSAGENPIQGATSE
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCHH
SLAKAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTHLDNAK
HHHHHHHCCCCCCCCHHHCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCC
RCPPSLAA
CCCCCCCC
>Mature Secondary Structure 
SLWFCPLTSTLNRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDSRENTAVEQLRAQG
CEEEECCHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCC
VRVFRDQSAANIDAICSNVDLLPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQ
HHEECCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVPYYDSNGHVGKGRLLVAEADE
CCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEECCCCCCCCCEEEEEECCC
SDGSLVKFQATLGVITNLELDHTDHYANLDELINTMKRFGQGCRRLLANFDCPILKEHFD
CCCCEEEEEEEEEEHEECEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
ATAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAA
CEEEEEEECCCCCCEEEEEEEECCCHHHHHHHHCCHHCCEEECCCCCCHHHHHHHHHHHH
CRLEGLSFEDVQQGLADLQPPGRRFDFRGTWEGRQIVDDYAHHPSEVSATLTMARLIVTS
HHHCCCCHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHC
GRSQLPNPPKRILAVFQPHRYSRTNKFLYDFARALGEADAVLLAPVYSAGENPIQGATSE
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCHH
SLAKAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTHLDNAK
HHHHHHHCCCCCCCCHHHCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCC
RCPPSLAA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA