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The map label for this gene is nadC

Identifier: 32267332

GI number: 32267332

Start: 1754869

End: 1755699

Strand: Direct

Name: nadC

Synonym: HH1833

Alternate gene names: 32267332

Gene position: 1754869-1755699 (Clockwise)

Preceding gene: 32267331

Following gene: 32267333

Centisome position: 97.54

GC content: 35.86

Gene sequence:

>831_bases
ATGTTGCAACATCATATTAAAGACTTTATTAAAAAAGCTCTTGATGAAGATTTGGGCAGAGGAGATTTATACGCTCTTTT
TGCAACCGATAAGGAAGTTCAAGCTTATATCATTGCCAAACAAGAGGGTGTATTTTCTGGGGAAATATATCTTAAAGCAA
TGCTTGAGCATTTTCAACTTGCCCTTGTATCATCATATTCAGATGGCGAATCCTTTGCAAAAGGCGCGATTTTATGTAAT
ATAAAAGGAAGTCATATCCATATTTTACAGCTAGAACGTGTGTTGCTCAATATTCTCGCTCATAGTAGTGGAATAGCTAC
TCTCACGGCTTCTTATGTGAGATTAATAAAGGATATGCACGTTAAACTTCTTGATACACGTAAAACCCGTCCATTGTTGC
GCCAACTTGAAAAATATTCTATTGTTAATGGTGGGGGGCATAATCATCGTTTTGGGCTTGATAGTATGCTTATGTTAAAA
GATACACATTTAGCTTATGCTGGGAATCTTAAAGAACTTATTAGCACCGCAAGAGAAAGATTGCCATTTATGTGTCCTAT
TGAAATAGAATGCGAAAATTACAAACAGGCAAAAGAGGCGATACAAGCCAAAGCAGATGTAATTATGTGCGATAATATGA
GTATAGAGGAGATTAAAGAAGTAGTAGCATATCGCAATGCAAATGCACCTTATATTTGCATTGAAGCAAGTGGTAATATT
AATCTTAAAAATATTGTGCAATATGCTTCTAGCGGTGTAGATGCTATTAGTGTAGGCTCACTTATTCATCAAGCTCAATG
GCTTGATTTGAGCCTCAAAATTGAAGGCTAG

Upstream 100 bases:

>100_bases
TTTTCAATATTCGCGCGGCTTTATAAGCCTTTGTGCGAATATTGCTTCAATTATGCTATTATCTTACTCTTAATTATTTA
AAAAAAGCCAAAGGCACACA

Downstream 100 bases:

>100_bases
GTTGTGATAAGATTTGATAGAGAATCATTTTTTATTCATACATTACAATCAGAGGGAATTACACAAGGAATAGGTGATGA
TTGTTGTGTGTTTTTTCCAC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MLQHHIKDFIKKALDEDLGRGDLYALFATDKEVQAYIIAKQEGVFSGEIYLKAMLEHFQLALVSSYSDGESFAKGAILCN
IKGSHIHILQLERVLLNILAHSSGIATLTASYVRLIKDMHVKLLDTRKTRPLLRQLEKYSIVNGGGHNHRFGLDSMLMLK
DTHLAYAGNLKELISTARERLPFMCPIEIECENYKQAKEAIQAKADVIMCDNMSIEEIKEVVAYRNANAPYICIEASGNI
NLKNIVQYASSGVDAISVGSLIHQAQWLDLSLKIEG

Sequences:

>Translated_276_residues
MLQHHIKDFIKKALDEDLGRGDLYALFATDKEVQAYIIAKQEGVFSGEIYLKAMLEHFQLALVSSYSDGESFAKGAILCN
IKGSHIHILQLERVLLNILAHSSGIATLTASYVRLIKDMHVKLLDTRKTRPLLRQLEKYSIVNGGGHNHRFGLDSMLMLK
DTHLAYAGNLKELISTARERLPFMCPIEIECENYKQAKEAIQAKADVIMCDNMSIEEIKEVVAYRNANAPYICIEASGNI
NLKNIVQYASSGVDAISVGSLIHQAQWLDLSLKIEG
>Mature_276_residues
MLQHHIKDFIKKALDEDLGRGDLYALFATDKEVQAYIIAKQEGVFSGEIYLKAMLEHFQLALVSSYSDGESFAKGAILCN
IKGSHIHILQLERVLLNILAHSSGIATLTASYVRLIKDMHVKLLDTRKTRPLLRQLEKYSIVNGGGHNHRFGLDSMLMLK
DTHLAYAGNLKELISTARERLPFMCPIEIECENYKQAKEAIQAKADVIMCDNMSIEEIKEVVAYRNANAPYICIEASGNI
NLKNIVQYASSGVDAISVGSLIHQAQWLDLSLKIEG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=270, Percent_Identity=32.5925925925926, Blast_Score=145, Evalue=3e-35,
Organism=Escherichia coli, GI1786299, Length=280, Percent_Identity=34.6428571428571, Blast_Score=146, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321162, Length=277, Percent_Identity=32.4909747292419, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30832; Mature: 30832

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQHHIKDFIKKALDEDLGRGDLYALFATDKEVQAYIIAKQEGVFSGEIYLKAMLEHFQL
CCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
ALVSSYSDGESFAKGAILCNIKGSHIHILQLERVLLNILAHSSGIATLTASYVRLIKDMH
HHHHCCCCCCHHCCCEEEEEECCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VKLLDTRKTRPLLRQLEKYSIVNGGGHNHRFGLDSMLMLKDTHLAYAGNLKELISTARER
HHHHHCCCCHHHHHHHHHHCEECCCCCCCCCCCCCEEEEECCCHHHCCCHHHHHHHHHHC
LPFMCPIEIECENYKQAKEAIQAKADVIMCDNMSIEEIKEVVAYRNANAPYICIEASGNI
CCCCCEEEEECCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCC
NLKNIVQYASSGVDAISVGSLIHQAQWLDLSLKIEG
CHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEEECC
>Mature Secondary Structure
MLQHHIKDFIKKALDEDLGRGDLYALFATDKEVQAYIIAKQEGVFSGEIYLKAMLEHFQL
CCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
ALVSSYSDGESFAKGAILCNIKGSHIHILQLERVLLNILAHSSGIATLTASYVRLIKDMH
HHHHCCCCCCHHCCCEEEEEECCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VKLLDTRKTRPLLRQLEKYSIVNGGGHNHRFGLDSMLMLKDTHLAYAGNLKELISTARER
HHHHHCCCCHHHHHHHHHHCEECCCCCCCCCCCCCEEEEECCCHHHCCCHHHHHHHHHHC
LPFMCPIEIECENYKQAKEAIQAKADVIMCDNMSIEEIKEVVAYRNANAPYICIEASGNI
CCCCCEEEEECCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCC
NLKNIVQYASSGVDAISVGSLIHQAQWLDLSLKIEG
CHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]