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The map label for this gene is thiL

Identifier: 32267333

GI number: 32267333

Start: 1755703

End: 1756704

Strand: Direct

Name: thiL

Synonym: HH1834

Alternate gene names: 32267333

Gene position: 1755703-1756704 (Clockwise)

Preceding gene: 32267332

Following gene: 32267334

Centisome position: 97.59

GC content: 34.33

Gene sequence:

>1002_bases
GTGATAAGATTTGATAGAGAATCATTTTTTATTCATACATTACAATCAGAGGGAATTACACAAGGAATAGGTGATGATTG
TTGTGTGTTTTTTCCACAAGGACAATTTAATAAGTCTTATCGCTCACATAAAGCGCATATCAAAACACATTATTTGCAGA
CAGCTATCCATATAAATACTCATTCTAAAGTGCAACAAAAAGCAAATATTTCGCCTTTTGTTGTCGGTATGGATAGTTTT
TGTGAAGGAGTGCATTTTCTTACACATTGGTTTACACCTTACCAACTTGCTTTTAAGGCTTTTTTGGTTAATTGTTCTGA
TATTATAGCGATGAATGCTACTCCTGCTTATGCAATGCTAAGTATTAGCTTGCCTAAATATTGGACTAAAATAGAGATTA
AAGATTTTGTTCGAGGCGTGGGAGATTTTTGTCGCAAATATAATGTAAAACTTATCGGGGGCGATACCATTAGTTCTCAA
AATTTACAGATTCATATTACTTTTTTTGGAATAGCCCATAAACACACGCTCTATCGTGATAAAATTCCTGCAGGTTCAGT
GCTTTTTTATACTTGCGATAAATATCCACGGCATACTATCACTCAAAGTTATAAAGTGCTAAAAAACCTCCTTTACCAAC
CTAAAAATCGTATTTTATATCCCAAAGGCAGATTTTTAATGCCATATATTCGTAAAAACTTTGTGTATCATTGTGCACCA
TTTTTAAAAGGAGGTATGGATATTTCTGATGGAATCTTAAGTGAAATTACACGTCTTTGCACAATCAATCATCTTTATTT
TAAGCCATCTATCCCTCTTTTTCGCCCACATATCAAGATGCTTTTACACAGCGGAGAAGAATATGAAATGCTCCTTGCTG
TATCTCCCAAAGATATTTTAAGATTAAAGCGACAAGCCCTAAGGCATAGAATCTTTGTGCGTCAAATCGGCACTCTCACA
CATAGAGGAAGAATGTTACCACCTCGTAAGTATTGGCATTAA

Upstream 100 bases:

>100_bases
TGTGCAATATGCTTCTAGCGGTGTAGATGCTATTAGTGTAGGCTCACTTATTCATCAAGCTCAATGGCTTGATTTGAGCC
TCAAAATTGAAGGCTAGGTT

Downstream 100 bases:

>100_bases
GGAGTAAAAATGGTTATTGTCTTAGCTAGTGCAAACCAACATAAGATTTGTGAATTTCAAGCAATGCTTAAAAATGTGAA
AGAAAAAGTAAAAGTTTATG

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIRFDRESFFIHTLQSEGITQGIGDDCCVFFPQGQFNKSYRSHKAHIKTHYLQTAIHINTHSKVQQKANISPFVVGMDSF
CEGVHFLTHWFTPYQLAFKAFLVNCSDIIAMNATPAYAMLSISLPKYWTKIEIKDFVRGVGDFCRKYNVKLIGGDTISSQ
NLQIHITFFGIAHKHTLYRDKIPAGSVLFYTCDKYPRHTITQSYKVLKNLLYQPKNRILYPKGRFLMPYIRKNFVYHCAP
FLKGGMDISDGILSEITRLCTINHLYFKPSIPLFRPHIKMLLHSGEEYEMLLAVSPKDILRLKRQALRHRIFVRQIGTLT
HRGRMLPPRKYWH

Sequences:

>Translated_333_residues
MIRFDRESFFIHTLQSEGITQGIGDDCCVFFPQGQFNKSYRSHKAHIKTHYLQTAIHINTHSKVQQKANISPFVVGMDSF
CEGVHFLTHWFTPYQLAFKAFLVNCSDIIAMNATPAYAMLSISLPKYWTKIEIKDFVRGVGDFCRKYNVKLIGGDTISSQ
NLQIHITFFGIAHKHTLYRDKIPAGSVLFYTCDKYPRHTITQSYKVLKNLLYQPKNRILYPKGRFLMPYIRKNFVYHCAP
FLKGGMDISDGILSEITRLCTINHLYFKPSIPLFRPHIKMLLHSGEEYEMLLAVSPKDILRLKRQALRHRIFVRQIGTLT
HRGRMLPPRKYWH
>Mature_333_residues
MIRFDRESFFIHTLQSEGITQGIGDDCCVFFPQGQFNKSYRSHKAHIKTHYLQTAIHINTHSKVQQKANISPFVVGMDSF
CEGVHFLTHWFTPYQLAFKAFLVNCSDIIAMNATPAYAMLSISLPKYWTKIEIKDFVRGVGDFCRKYNVKLIGGDTISSQ
NLQIHITFFGIAHKHTLYRDKIPAGSVLFYTCDKYPRHTITQSYKVLKNLLYQPKNRILYPKGRFLMPYIRKNFVYHCAP
FLKGGMDISDGILSEITRLCTINHLYFKPSIPLFRPHIKMLLHSGEEYEMLLAVSPKDILRLKRQALRHRIFVRQIGTLT
HRGRMLPPRKYWH

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 38850; Mature: 38850

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRFDRESFFIHTLQSEGITQGIGDDCCVFFPQGQFNKSYRSHKAHIKTHYLQTAIHINT
CCEECCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHEEEEEEEEECC
HSKVQQKANISPFVVGMDSFCEGVHFLTHWFTPYQLAFKAFLVNCSDIIAMNATPAYAML
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHEEEECCCCCEEEE
SISLPKYWTKIEIKDFVRGVGDFCRKYNVKLIGGDTISSQNLQIHITFFGIAHKHTLYRD
EEECCCHHEEEEHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEEEEEEHHHHHHHC
KIPAGSVLFYTCDKYPRHTITQSYKVLKNLLYQPKNRILYPKGRFLMPYIRKNFVYHCAP
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCEEHHHHHHHHHHHHHH
FLKGGMDISDGILSEITRLCTINHLYFKPSIPLFRPHIKMLLHSGEEYEMLLAVSPKDIL
HHCCCCCCCHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCHHHH
RLKRQALRHRIFVRQIGTLTHRGRMLPPRKYWH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCC
>Mature Secondary Structure
MIRFDRESFFIHTLQSEGITQGIGDDCCVFFPQGQFNKSYRSHKAHIKTHYLQTAIHINT
CCEECCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHEEEEEEEEECC
HSKVQQKANISPFVVGMDSFCEGVHFLTHWFTPYQLAFKAFLVNCSDIIAMNATPAYAML
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHEEEECCCCCEEEE
SISLPKYWTKIEIKDFVRGVGDFCRKYNVKLIGGDTISSQNLQIHITFFGIAHKHTLYRD
EEECCCHHEEEEHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEEEEEEHHHHHHHC
KIPAGSVLFYTCDKYPRHTITQSYKVLKNLLYQPKNRILYPKGRFLMPYIRKNFVYHCAP
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCEEHHHHHHHHHHHHHH
FLKGGMDISDGILSEITRLCTINHLYFKPSIPLFRPHIKMLLHSGEEYEMLLAVSPKDIL
HHCCCCCCCHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCHHHH
RLKRQALRHRIFVRQIGTLTHRGRMLPPRKYWH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9202461; 9384377; 8419296 [H]