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The map label for this gene is fabL [H]

Identifier: 32267126

GI number: 32267126

Start: 1550059

End: 1550862

Strand: Direct

Name: fabL [H]

Synonym: HH1627

Alternate gene names: 32267126

Gene position: 1550059-1550862 (Clockwise)

Preceding gene: 32267125

Following gene: 32267127

Centisome position: 86.16

GC content: 38.18

Gene sequence:

>804_bases
ATGAAAAATGCTCAAGATTCTACAACACATTTTATGAAAGGCAAAACACTTGTTATTAGCGGTGCGACACGAGGTATTGG
CAAGGCAATTTTATATAAATTTGCTCAAAATGGTGTAAATGTCGCTTTTACTTATAATAAAAACGAAGAGGAAGCCCAAA
AGATCGCTCAAGATGTTGAAACTAAATATGGCATTAAAGCGAGATTTTATCCACTCAATGTGCTTGAACCAGAACAATAT
ATAGAATTATTTAAAAAAATTGATGAAGATTTTTCACGCGTAGATTTTTTTGTATCTAATGCGATTATTTATGGCAAAAG
TGTAGCGGGTGGATTTGCACCATTTATGCGACTTAAACCGCGTGGGCTTAATAACATTTATACAGCAACCGTGCTCGCTT
TTGTTGTAGGTGCGCAAGAAGCAGCTAAACGTATGAAAGAAGTTGGTGGTGGAGCTATTGTTTCTTTAAGTTCAACAGGG
AATCTTGTGTATATGCCAAATTATGCAGGACACGGAAATTCTAAAAATGCGGTAGAAACTATGGTAAAATATGCAGCGAC
AGAGCTTGGAGAGTGGGGCATACGTGTAAATGCAGTGAGTGGAGGACCTATTGATACCGATGCGCTCAAAGCATTTCCTG
ATTATGCACAAGTAAAGGCTAAGGTGGAGGAAGAATCTCCTCTTAATCGTATGGGAACACCTGAAGATTTAGCAGGAGCA
GCATTTTTTCTTTGTGATGAAACGCAAAGTGCGTGGCTTACAGGACAGACAATCGTTATTGATGGTGGCACAACATTTAA
ATAA

Upstream 100 bases:

>100_bases
GATTATTAAAAAACTTGGAATATCGTTTGCCATTAGTGCCACCTTCTAAGGAAAATATGGCTAAAATACAACAAATCTTA
GAAAAATACGAGGTGAAAGA

Downstream 100 bases:

>100_bases
TGTCTTATTTACATTCAATACAGCTTTATTTTATGCGATTAATGAGGCAAATACGCCTCAGATTTATTTCTATACCTTAT
ACGCATTTTTCTTTTTATAA

Product: 7-alpha-hydroxysteroid dehydrogenase

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MKNAQDSTTHFMKGKTLVISGATRGIGKAILYKFAQNGVNVAFTYNKNEEEAQKIAQDVETKYGIKARFYPLNVLEPEQY
IELFKKIDEDFSRVDFFVSNAIIYGKSVAGGFAPFMRLKPRGLNNIYTATVLAFVVGAQEAAKRMKEVGGGAIVSLSSTG
NLVYMPNYAGHGNSKNAVETMVKYAATELGEWGIRVNAVSGGPIDTDALKAFPDYAQVKAKVEEESPLNRMGTPEDLAGA
AFFLCDETQSAWLTGQTIVIDGGTTFK

Sequences:

>Translated_267_residues
MKNAQDSTTHFMKGKTLVISGATRGIGKAILYKFAQNGVNVAFTYNKNEEEAQKIAQDVETKYGIKARFYPLNVLEPEQY
IELFKKIDEDFSRVDFFVSNAIIYGKSVAGGFAPFMRLKPRGLNNIYTATVLAFVVGAQEAAKRMKEVGGGAIVSLSSTG
NLVYMPNYAGHGNSKNAVETMVKYAATELGEWGIRVNAVSGGPIDTDALKAFPDYAQVKAKVEEESPLNRMGTPEDLAGA
AFFLCDETQSAWLTGQTIVIDGGTTFK
>Mature_267_residues
MKNAQDSTTHFMKGKTLVISGATRGIGKAILYKFAQNGVNVAFTYNKNEEEAQKIAQDVETKYGIKARFYPLNVLEPEQY
IELFKKIDEDFSRVDFFVSNAIIYGKSVAGGFAPFMRLKPRGLNNIYTATVLAFVVGAQEAAKRMKEVGGGAIVSLSSTG
NLVYMPNYAGHGNSKNAVETMVKYAATELGEWGIRVNAVSGGPIDTDALKAFPDYAQVKAKVEEESPLNRMGTPEDLAGA
AFFLCDETQSAWLTGQTIVIDGGTTFK

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=27.6679841897233, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=25.3012048192771, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI19923817, Length=273, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI126723750, Length=259, Percent_Identity=25.8687258687259, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=27.4131274131274, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4503301, Length=218, Percent_Identity=29.3577981651376, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=30.6451612903226, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=30.5555555555556, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI2367365, Length=249, Percent_Identity=30.1204819277108, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1787545, Length=271, Percent_Identity=28.0442804428044, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=29.4820717131474, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=27.4900398406374, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=24.7058823529412, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082100, Length=270, Percent_Identity=28.5185185185185, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=27.906976744186, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=25.6916996047431, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=23.6434108527132, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1786812, Length=266, Percent_Identity=23.6842105263158, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=31.3953488372093, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=29.1044776119403, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562910, Length=274, Percent_Identity=30.2919708029197, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=28.7937743190661, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=275, Percent_Identity=29.4545454545455, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=277, Percent_Identity=27.4368231046931, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=28.8888888888889, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=272, Percent_Identity=28.6764705882353, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=288, Percent_Identity=28.125, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=267, Percent_Identity=28.8389513108614, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=272, Percent_Identity=28.6764705882353, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=279, Percent_Identity=27.9569892473118, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=26.4925373134328, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=273, Percent_Identity=27.8388278388278, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=280, Percent_Identity=26.4285714285714, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17508651, Length=261, Percent_Identity=27.2030651340996, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=248, Percent_Identity=26.6129032258064, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=252, Percent_Identity=25.3968253968254, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=24.609375, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=276, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=262, Percent_Identity=22.9007633587786, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=259, Percent_Identity=27.7992277992278, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355319, Length=260, Percent_Identity=27.6923076923077, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24639444, Length=259, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=27.6264591439689, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644337, Length=117, Percent_Identity=37.6068376068376, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24644339, Length=257, Percent_Identity=26.4591439688716, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24643142, Length=263, Percent_Identity=24.3346007604563, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI23397609, Length=265, Percent_Identity=26.0377358490566, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 29029; Mature: 29029

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNAQDSTTHFMKGKTLVISGATRGIGKAILYKFAQNGVNVAFTYNKNEEEAQKIAQDVE
CCCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHH
TKYGIKARFYPLNVLEPEQYIELFKKIDEDFSRVDFFVSNAIIYGKSVAGGFAPFMRLKP
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHCCC
RGLNNIYTATVLAFVVGAQEAAKRMKEVGGGAIVSLSSTGNLVYMPNYAGHGNSKNAVET
CCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHH
MVKYAATELGEWGIRVNAVSGGPIDTDALKAFPDYAQVKAKVEEESPLNRMGTPEDLAGA
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHCCE
AFFLCDETQSAWLTGQTIVIDGGTTFK
EEEEECCCCCCEEECCEEEEECCCCCC
>Mature Secondary Structure
MKNAQDSTTHFMKGKTLVISGATRGIGKAILYKFAQNGVNVAFTYNKNEEEAQKIAQDVE
CCCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHH
TKYGIKARFYPLNVLEPEQYIELFKKIDEDFSRVDFFVSNAIIYGKSVAGGFAPFMRLKP
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHCCC
RGLNNIYTATVLAFVVGAQEAAKRMKEVGGGAIVSLSSTGNLVYMPNYAGHGNSKNAVET
CCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHH
MVKYAATELGEWGIRVNAVSGGPIDTDALKAFPDYAQVKAKVEEESPLNRMGTPEDLAGA
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHCCE
AFFLCDETQSAWLTGQTIVIDGGTTFK
EEEEECCCCCCEEECCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]