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The map label for this gene is pqqL [C]

Identifier: 32267124

GI number: 32267124

Start: 1547880

End: 1549178

Strand: Direct

Name: pqqL [C]

Synonym: HH1625

Alternate gene names: 32267124

Gene position: 1547880-1549178 (Clockwise)

Preceding gene: 32267123

Following gene: 32267125

Centisome position: 86.03

GC content: 34.26

Gene sequence:

>1299_bases
ATGAGTATTTCTAATATGGTGAGCATCCCATCATTGGTCCCAAGTTCCTTGCCAAAACATTATACAAAACATCTTGATAA
TGGACTACAAATTGTGGTCGTGCCATTGAATAATAAGAGTGGTGTAATTGAGACAAATATTTTTTATAAGGTTGGAAGTC
GTAATGAAGTAATGGGCAAAAGTGGCATTGCACATATGCTTGAGCATTTAAGCTTTAAATCCACGGATAAGCTCAAAGCA
GGAGAATTTGATGAGATTGTAAAAGGCTTTGGAGGTGTGAATAATGCTTCAACAAGCTTTGATTATACACGTTATTTTAT
TAAATCAAGCGTTGAGAATCTTGATAAATCTTTAGAGCTTTTTTCTGAACTTATGAGTAATCTTTTGTTAAAAGAAGATG
AGTTTGAACCCGAACGCAATGTAGTAGCAGAGGAGCGATTGTGGCGGACAGATAATTCACCTATGGGATATTTATATTTT
CGTTTCTTTAATACTGCTTTTGTCTATCACCCTTATCATTGGACACCTATTGGTTTTATGCAAGATATTCAAAGCTGGAA
TATTGATGATATTCGCTCATTTTATCGCACTTATTACCAACCACAGAATGCTATTGTATTAGTAAGTGGCGATATTGAAC
CAAATGTTGTTTTTCAAAGTGCAACTCAATATTTTGGAAAACTTAAAAATACTTCTTCGGATATTCCGCAAGTTAGAGCA
AAAGAGCCAAAACAAGATGGTATGAGGCGCAATATAGTAAAAAAAGATTCTCAAGTGGAGTTTCTTGCTATGGGATATAA
GATTCCTAATTATTTAAGCGAAGACCAAGTGGCATTAAGCGCAATAGGCGAGATTCTAAGCGCTGGTAAATCAAGTATTT
TTCAGAGAGAACTTATTGATAAACAGCAAATTGCCACTAGCGCATACGCATATAATATGGATATGAAAGATGAGAGTGTA
TTTTTACTCATTGTTGCAGCAAAACAGGGTGTCAGAGCTGAAAAAATTGAAGAAGAAGTGATTAAGATATTAGAAAATAT
TAAAAAAGGTCATATTTCCCAAGAAGAGCTTGATAAGGTTAAGGTCAATACGCGTGCAAATTTTATTTATAGTCTTGAAA
ATTCTTCAGAGGTTGCAGGGCTTTTTGGGAGTTATCTTGTGCGAGGAGATATTAAACCATTACTTTCTTATGAAAGAGAT
ATAAATACTCTTAACTTAGATAAGATTCAGCAGGTAGCAAATAAATATTTTGTAGAAGATACACTAAGTGTGGTGATTTT
AAAGGACAAGGGGAGGTGA

Upstream 100 bases:

>100_bases
AAACTTATCTAACTCACAGCCCTCATTATCTAAAGTGAGGGAAAATACGGCAGAGATTCCCAAAGAGTAAGCTGTGAAGT
TTTTGATTTTAGGAGTATTA

Downstream 100 bases:

>100_bases
TTATGGTTTTTGGGGCAATGAGTGCATTAATCACACCATTTATAAATCATAAGGTTGATTTTGAAACATATGAAACACTC
ATTAAGCGGCAAATTACCTA

Product: putative zinc protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSISNMVSIPSLVPSSLPKHYTKHLDNGLQIVVVPLNNKSGVIETNIFYKVGSRNEVMGKSGIAHMLEHLSFKSTDKLKA
GEFDEIVKGFGGVNNASTSFDYTRYFIKSSVENLDKSLELFSELMSNLLLKEDEFEPERNVVAEERLWRTDNSPMGYLYF
RFFNTAFVYHPYHWTPIGFMQDIQSWNIDDIRSFYRTYYQPQNAIVLVSGDIEPNVVFQSATQYFGKLKNTSSDIPQVRA
KEPKQDGMRRNIVKKDSQVEFLAMGYKIPNYLSEDQVALSAIGEILSAGKSSIFQRELIDKQQIATSAYAYNMDMKDESV
FLLIVAAKQGVRAEKIEEEVIKILENIKKGHISQEELDKVKVNTRANFIYSLENSSEVAGLFGSYLVRGDIKPLLSYERD
INTLNLDKIQQVANKYFVEDTLSVVILKDKGR

Sequences:

>Translated_432_residues
MSISNMVSIPSLVPSSLPKHYTKHLDNGLQIVVVPLNNKSGVIETNIFYKVGSRNEVMGKSGIAHMLEHLSFKSTDKLKA
GEFDEIVKGFGGVNNASTSFDYTRYFIKSSVENLDKSLELFSELMSNLLLKEDEFEPERNVVAEERLWRTDNSPMGYLYF
RFFNTAFVYHPYHWTPIGFMQDIQSWNIDDIRSFYRTYYQPQNAIVLVSGDIEPNVVFQSATQYFGKLKNTSSDIPQVRA
KEPKQDGMRRNIVKKDSQVEFLAMGYKIPNYLSEDQVALSAIGEILSAGKSSIFQRELIDKQQIATSAYAYNMDMKDESV
FLLIVAAKQGVRAEKIEEEVIKILENIKKGHISQEELDKVKVNTRANFIYSLENSSEVAGLFGSYLVRGDIKPLLSYERD
INTLNLDKIQQVANKYFVEDTLSVVILKDKGR
>Mature_431_residues
SISNMVSIPSLVPSSLPKHYTKHLDNGLQIVVVPLNNKSGVIETNIFYKVGSRNEVMGKSGIAHMLEHLSFKSTDKLKAG
EFDEIVKGFGGVNNASTSFDYTRYFIKSSVENLDKSLELFSELMSNLLLKEDEFEPERNVVAEERLWRTDNSPMGYLYFR
FFNTAFVYHPYHWTPIGFMQDIQSWNIDDIRSFYRTYYQPQNAIVLVSGDIEPNVVFQSATQYFGKLKNTSSDIPQVRAK
EPKQDGMRRNIVKKDSQVEFLAMGYKIPNYLSEDQVALSAIGEILSAGKSSIFQRELIDKQQIATSAYAYNMDMKDESVF
LLIVAAKQGVRAEKIEEEVIKILENIKKGHISQEELDKVKVNTRANFIYSLENSSEVAGLFGSYLVRGDIKPLLSYERDI
NTLNLDKIQQVANKYFVEDTLSVVILKDKGR

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=424, Percent_Identity=21.2264150943396, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI94538354, Length=418, Percent_Identity=19.8564593301435, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787770, Length=281, Percent_Identity=26.6903914590747, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71999683, Length=435, Percent_Identity=23.6781609195402, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17553678, Length=440, Percent_Identity=22.0454545454545, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323192, Length=431, Percent_Identity=23.2018561484919, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI21357875, Length=424, Percent_Identity=19.5754716981132, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24646943, Length=424, Percent_Identity=19.5754716981132, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 49232; Mature: 49100

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISNMVSIPSLVPSSLPKHYTKHLDNGLQIVVVPLNNKSGVIETNIFYKVGSRNEVMGK
CCCCHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEEEEECCCCCCCCH
SGIAHMLEHLSFKSTDKLKAGEFDEIVKGFGGVNNASTSFDYTRYFIKSSVENLDKSLEL
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FSELMSNLLLKEDEFEPERNVVAEERLWRTDNSPMGYLYFRFFNTAFVYHPYHWTPIGFM
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEECCCCCCHHHHH
QDIQSWNIDDIRSFYRTYYQPQNAIVLVSGDIEPNVVFQSATQYFGKLKNTSSDIPQVRA
HHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
KEPKQDGMRRNIVKKDSQVEFLAMGYKIPNYLSEDQVALSAIGEILSAGKSSIFQRELID
CCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQQIATSAYAYNMDMKDESVFLLIVAAKQGVRAEKIEEEVIKILENIKKGHISQEELDKV
HHHHHHHHHEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHE
KVNTRANFIYSLENSSEVAGLFGSYLVRGDIKPLLSYERDINTLNLDKIQQVANKYFVED
EEECCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
TLSVVILKDKGR
CEEEEEEECCCC
>Mature Secondary Structure 
SISNMVSIPSLVPSSLPKHYTKHLDNGLQIVVVPLNNKSGVIETNIFYKVGSRNEVMGK
CCCHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEEEEECCCCCCCCH
SGIAHMLEHLSFKSTDKLKAGEFDEIVKGFGGVNNASTSFDYTRYFIKSSVENLDKSLEL
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FSELMSNLLLKEDEFEPERNVVAEERLWRTDNSPMGYLYFRFFNTAFVYHPYHWTPIGFM
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEECCCCCCHHHHH
QDIQSWNIDDIRSFYRTYYQPQNAIVLVSGDIEPNVVFQSATQYFGKLKNTSSDIPQVRA
HHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
KEPKQDGMRRNIVKKDSQVEFLAMGYKIPNYLSEDQVALSAIGEILSAGKSSIFQRELID
CCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQQIATSAYAYNMDMKDESVFLLIVAAKQGVRAEKIEEEVIKILENIKKGHISQEELDKV
HHHHHHHHHEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHE
KVNTRANFIYSLENSSEVAGLFGSYLVRGDIKPLLSYERDINTLNLDKIQQVANKYFVED
EEECCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
TLSVVILKDKGR
CEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]