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The map label for this gene is pyrD

Identifier: 32267123

GI number: 32267123

Start: 1546443

End: 1547849

Strand: Direct

Name: pyrD

Synonym: HH1624

Alternate gene names: 32267123

Gene position: 1546443-1547849 (Clockwise)

Preceding gene: 32267122

Following gene: 32267124

Centisome position: 85.95

GC content: 37.1

Gene sequence:

>1407_bases
ATGTCATTGTATAAAATGCTTTCCCCTTATCTTTTTAAGCTTGATGCTGAAAAGGCTCATTGTATGGCAGAATTGGCACT
TAAGCATATAGTGCCTTTGCCTTTAGTGCAAGATTATGTAGCTGGAAAATATTGTGTTGTTGATGAGCACTTAAATATGG
AAGTTGCTGGTCTGAGATTCTACAATCCAGTAGGTTTGGCTGCAGGATTTGATAAAAATGCAACGATGGTGCGAGGACTT
TCGGCATTGGGATTTGGCTTTTTAGAGATTGGTACAATTACCCAATCTCCCCAAGAGGGAAATCCAAAACCTCGCCTTTT
TCGTTATGTAGAGGAAAGAAGTTTGCAAAATGAAATGGGGTTTAACAATCAAGGTTCGCTTGAAATAGTGCAACGCCTTA
AAAATATTTATCCTTATAGTATTCCGCTTGGGATTAATGTAGGTAAAAATAAAATTATTGCACAAAGTGATTCGCTTAAA
AATTATGAAAATGTTTTACTTGATTGTTTGTCTGTGGGAGATTATTTTGTTTTTAATCTCTCCTCTCCAAATACACCGAA
TTTACGTGATTTGCAGAATGTGCATTTTGTGCAAGAGCTTTTTACTATGGCACGCTCATATACTCAAAAACCGCTTTTTA
TAAAAATATCTCCCGATATGGATAAAGATGAAATGCTCAAAATAGTTGAAATGAGTATCAAATATGGTGCAAATGGTGTG
ATTGCAACAAATACCACTATTGATTATGCTGTGCTTACAAATGCAAGGGAGACAGGAGGCATTAGTGGTGAGGCATTAAA
AAAGAAGTCAAAAGAAGTGCTTAGAATCTTAAGTGAAGCATTTTTTGGCAAAACTGCCCTTATTTCTGTGGGAGGCGTTG
ATAGCGCACTTGAAGCTTATGAGCGTATCAAGCTTGGTGCATCACTTGTGCAAGTATTAAGTGGATTAATTTTTGAAGGT
CCAAGATTGTGTCAACAAATCAATGAGGGGCTACTTCAATATTTAAAAGAAGATGGTTTTACACATTTGTATGAGGCAGT
AGGGCAGGATATAGCCCATAAGCCAAAACGTGGAAGAAAATCAAAAGCGGCACAGGCATTGGATTCTATGGAGGTAAATA
CAGAGATTTCCACAAGCCTTCTCACAAGCAAGCCCAAAAAATCTGCTCAAAAAGTAGAATCTCAAAAGAAACCAGCTACT
ACAAGAAACACAAATGCAAATAGAGCATCTGCAACAAAAAAAACCGCCTCAAAGGAAAATGCAAAAGCACAACAAAAGTT
AGATTCTACAGAATCTCCAAAGCCAACGACACATAAGAATGTAAACTCTGCCAAGAAAAACTTATCTAACTCACAGCCCT
CATTATCTAAAGTGAGGGAAAATACGGCAGAGATTCCCAAAGAGTAA

Upstream 100 bases:

>100_bases
ATTTTAATGCTTAAAATATTGTTATGCGTGAGTTTATTTTTTTTGCTACAATAGCACCTTAAGTTTATTTCTTTAACTCA
TAACTTCATTGAGGTGTCTT

Downstream 100 bases:

>100_bases
GCTGTGAAGTTTTTGATTTTAGGAGTATTAATGAGTATTTCTAATATGGTGAGCATCCCATCATTGGTCCCAAGTTCCTT
GCCAAAACATTATACAAAAC

Product: dihydroorotate dehydrogenase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSLYKMLSPYLFKLDAEKAHCMAELALKHIVPLPLVQDYVAGKYCVVDEHLNMEVAGLRFYNPVGLAAGFDKNATMVRGL
SALGFGFLEIGTITQSPQEGNPKPRLFRYVEERSLQNEMGFNNQGSLEIVQRLKNIYPYSIPLGINVGKNKIIAQSDSLK
NYENVLLDCLSVGDYFVFNLSSPNTPNLRDLQNVHFVQELFTMARSYTQKPLFIKISPDMDKDEMLKIVEMSIKYGANGV
IATNTTIDYAVLTNARETGGISGEALKKKSKEVLRILSEAFFGKTALISVGGVDSALEAYERIKLGASLVQVLSGLIFEG
PRLCQQINEGLLQYLKEDGFTHLYEAVGQDIAHKPKRGRKSKAAQALDSMEVNTEISTSLLTSKPKKSAQKVESQKKPAT
TRNTNANRASATKKTASKENAKAQQKLDSTESPKPTTHKNVNSAKKNLSNSQPSLSKVRENTAEIPKE

Sequences:

>Translated_468_residues
MSLYKMLSPYLFKLDAEKAHCMAELALKHIVPLPLVQDYVAGKYCVVDEHLNMEVAGLRFYNPVGLAAGFDKNATMVRGL
SALGFGFLEIGTITQSPQEGNPKPRLFRYVEERSLQNEMGFNNQGSLEIVQRLKNIYPYSIPLGINVGKNKIIAQSDSLK
NYENVLLDCLSVGDYFVFNLSSPNTPNLRDLQNVHFVQELFTMARSYTQKPLFIKISPDMDKDEMLKIVEMSIKYGANGV
IATNTTIDYAVLTNARETGGISGEALKKKSKEVLRILSEAFFGKTALISVGGVDSALEAYERIKLGASLVQVLSGLIFEG
PRLCQQINEGLLQYLKEDGFTHLYEAVGQDIAHKPKRGRKSKAAQALDSMEVNTEISTSLLTSKPKKSAQKVESQKKPAT
TRNTNANRASATKKTASKENAKAQQKLDSTESPKPTTHKNVNSAKKNLSNSQPSLSKVRENTAEIPKE
>Mature_467_residues
SLYKMLSPYLFKLDAEKAHCMAELALKHIVPLPLVQDYVAGKYCVVDEHLNMEVAGLRFYNPVGLAAGFDKNATMVRGLS
ALGFGFLEIGTITQSPQEGNPKPRLFRYVEERSLQNEMGFNNQGSLEIVQRLKNIYPYSIPLGINVGKNKIIAQSDSLKN
YENVLLDCLSVGDYFVFNLSSPNTPNLRDLQNVHFVQELFTMARSYTQKPLFIKISPDMDKDEMLKIVEMSIKYGANGVI
ATNTTIDYAVLTNARETGGISGEALKKKSKEVLRILSEAFFGKTALISVGGVDSALEAYERIKLGASLVQVLSGLIFEGP
RLCQQINEGLLQYLKEDGFTHLYEAVGQDIAHKPKRGRKSKAAQALDSMEVNTEISTSLLTSKPKKSAQKVESQKKPATT
RNTNANRASATKKTASKENAKAQQKLDSTESPKPTTHKNVNSAKKNLSNSQPSLSKVRENTAEIPKE

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=358, Percent_Identity=37.1508379888268, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI119943098, Length=297, Percent_Identity=26.2626262626263, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787177, Length=339, Percent_Identity=39.8230088495575, Blast_Score=234, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17509475, Length=324, Percent_Identity=37.6543209876543, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI281361352, Length=356, Percent_Identity=37.6404494382022, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI17137316, Length=356, Percent_Identity=37.6404494382022, Blast_Score=221, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 51706; Mature: 51575

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLYKMLSPYLFKLDAEKAHCMAELALKHIVPLPLVQDYVAGKYCVVDEHLNMEVAGLRF
CCHHHHHCHHHEEECCHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCEEEECEEE
YNPVGLAAGFDKNATMVRGLSALGFGFLEIGTITQSPQEGNPKPRLFRYVEERSLQNEMG
ECCCCCCCCCCCCHHHHHHHHHHCCCHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
FNNQGSLEIVQRLKNIYPYSIPLGINVGKNKIIAQSDSLKNYENVLLDCLSVGDYFVFNL
CCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEEEEC
SSPNTPNLRDLQNVHFVQELFTMARSYTQKPLFIKISPDMDKDEMLKIVEMSIKYGANGV
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCE
IATNTTIDYAVLTNARETGGISGEALKKKSKEVLRILSEAFFGKTALISVGGVDSALEAY
EEECCEEEEHEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHH
ERIKLGASLVQVLSGLIFEGPRLCQQINEGLLQYLKEDGFTHLYEAVGQDIAHKPKRGRK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHH
SKAAQALDSMEVNTEISTSLLTSKPKKSAQKVESQKKPATTRNTNANRASATKKTASKEN
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AKAQQKLDSTESPKPTTHKNVNSAKKNLSNSQPSLSKVRENTAEIPKE
HHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLYKMLSPYLFKLDAEKAHCMAELALKHIVPLPLVQDYVAGKYCVVDEHLNMEVAGLRF
CHHHHHCHHHEEECCHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCEEEECEEE
YNPVGLAAGFDKNATMVRGLSALGFGFLEIGTITQSPQEGNPKPRLFRYVEERSLQNEMG
ECCCCCCCCCCCCHHHHHHHHHHCCCHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
FNNQGSLEIVQRLKNIYPYSIPLGINVGKNKIIAQSDSLKNYENVLLDCLSVGDYFVFNL
CCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEEEEC
SSPNTPNLRDLQNVHFVQELFTMARSYTQKPLFIKISPDMDKDEMLKIVEMSIKYGANGV
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCE
IATNTTIDYAVLTNARETGGISGEALKKKSKEVLRILSEAFFGKTALISVGGVDSALEAY
EEECCEEEEHEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHH
ERIKLGASLVQVLSGLIFEGPRLCQQINEGLLQYLKEDGFTHLYEAVGQDIAHKPKRGRK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHH
SKAAQALDSMEVNTEISTSLLTSKPKKSAQKVESQKKPATTRNTNANRASATKKTASKEN
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AKAQQKLDSTESPKPTTHKNVNSAKKNLSNSQPSLSKVRENTAEIPKE
HHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA