Click here to switch to the map view.

The map label for this gene is tsaA

Identifier: 32267043

GI number: 32267043

Start: 1480946

End: 1481542

Strand: Direct

Name: tsaA

Synonym: HH1544

Alternate gene names: 32267043

Gene position: 1480946-1481542 (Clockwise)

Preceding gene: 32267042

Following gene: 32267045

Centisome position: 82.31

GC content: 39.03

Gene sequence:

>597_bases
ATGTTAGTTACAAAACCAGCACCAGATTTTACAGCGGAGGCGATTAAAGCAGATGGAACTTTTGAGGATAGTTTTAACCT
CTACAAAAACATCGGTAAGAATGGTGCAGTTGTATTTTTTTGGCCTAAGGATTTTACTTTTGTATGTCCTAGTGAGATTA
TTGCTTTTGACAAACGCGTGAAAGATTTTGAAGCACGCGGTGTAAAAGTGATTGGAGTATCTATTGATTCTAAAGAAGTG
CATTTTGCGTGGAGAAATGTGCCTGTAAATCAAGGAGGGATTGGCGCAGTAACATTCCCTATGGTATCTGATATTACAAA
ACAAATCTCTCGTGATTATGATGTGCTTTTTAATGGTGCAGTTGCACTTCGCGGTAGCTTCCTTATTGATAAAAATAAAG
TAGTTCGCCACGCAGTCATTAATGACCTTCCACTTGGACGTAATGTTGATGAAATGATTCGTATGGTAGATGCGATGTTG
TTTGTTGAAGAGCACGGCGAAGTATGTCCTGCAGGCTGGAATAAAGGTGATGAGGGTATGAAAGCTAATGCTAAAGGTGT
AGCAGAATACCTTGCTAAAAATGCTGATAAGCTCTAA

Upstream 100 bases:

>100_bases
AATATAATAAATTGATATTGTTACTATTGAGTTACTTGTGCGTATTACAATAGCATTTCAATAACAATTTGTTATTAATA
TTTTTTATTAGGAGTTCAAT

Downstream 100 bases:

>100_bases
GACGATACAAAAGCTACAACCTTGCACTTTTTGTGCGAGGATAGCTTTAACAAGCTACTTTATTCTTTAATTTCTTTGTT
ATTTTATAATTCTGTTTTCT

Product: alkyl hydroperoxide reductase TsaA

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MLVTKPAPDFTAEAIKADGTFEDSFNLYKNIGKNGAVVFFWPKDFTFVCPSEIIAFDKRVKDFEARGVKVIGVSIDSKEV
HFAWRNVPVNQGGIGAVTFPMVSDITKQISRDYDVLFNGAVALRGSFLIDKNKVVRHAVINDLPLGRNVDEMIRMVDAML
FVEEHGEVCPAGWNKGDEGMKANAKGVAEYLAKNADKL

Sequences:

>Translated_198_residues
MLVTKPAPDFTAEAIKADGTFEDSFNLYKNIGKNGAVVFFWPKDFTFVCPSEIIAFDKRVKDFEARGVKVIGVSIDSKEV
HFAWRNVPVNQGGIGAVTFPMVSDITKQISRDYDVLFNGAVALRGSFLIDKNKVVRHAVINDLPLGRNVDEMIRMVDAML
FVEEHGEVCPAGWNKGDEGMKANAKGVAEYLAKNADKL
>Mature_198_residues
MLVTKPAPDFTAEAIKADGTFEDSFNLYKNIGKNGAVVFFWPKDFTFVCPSEIIAFDKRVKDFEARGVKVIGVSIDSKEV
HFAWRNVPVNQGGIGAVTFPMVSDITKQISRDYDVLFNGAVALRGSFLIDKNKVVRHAVINDLPLGRNVDEMIRMVDAML
FVEEHGEVCPAGWNKGDEGMKANAKGVAEYLAKNADKL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=194, Percent_Identity=47.9381443298969, Blast_Score=190, Evalue=6e-49,
Organism=Homo sapiens, GI4505591, Length=194, Percent_Identity=46.3917525773196, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI32455266, Length=194, Percent_Identity=46.3917525773196, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI32455264, Length=194, Percent_Identity=46.3917525773196, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI5802974, Length=193, Percent_Identity=46.6321243523316, Blast_Score=177, Evalue=7e-45,
Organism=Homo sapiens, GI5453549, Length=192, Percent_Identity=44.7916666666667, Blast_Score=175, Evalue=2e-44,
Organism=Homo sapiens, GI32483377, Length=189, Percent_Identity=46.5608465608466, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=52.4390243902439, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4758638, Length=190, Percent_Identity=27.3684210526316, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1786822, Length=144, Percent_Identity=31.25, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193204376, Length=195, Percent_Identity=48.2051282051282, Blast_Score=180, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI32565831, Length=195, Percent_Identity=48.2051282051282, Blast_Score=179, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17554494, Length=197, Percent_Identity=39.0862944162437, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25153706, Length=181, Percent_Identity=27.6243093922652, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=190, Percent_Identity=44.2105263157895, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320661, Length=195, Percent_Identity=42.0512820512821, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319407, Length=187, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17738015, Length=195, Percent_Identity=46.1538461538462, Blast_Score=184, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=46.3917525773196, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=46.3917525773196, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17157991, Length=194, Percent_Identity=41.2371134020619, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24641739, Length=194, Percent_Identity=41.2371134020619, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=40, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24581278, Length=180, Percent_Identity=27.2222222222222, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21873; Mature: 21873

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVTKPAPDFTAEAIKADGTFEDSFNLYKNIGKNGAVVFFWPKDFTFVCPSEIIAFDKRV
CCCCCCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEECCCCEEECCHHHHHHHHHH
KDFEARGVKVIGVSIDSKEVHFAWRNVPVNQGGIGAVTFPMVSDITKQISRDYDVLFNGA
HHHHHCCEEEEEEEECCCEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHCCCHHHEECCC
VALRGSFLIDKNKVVRHAVINDLPLGRNVDEMIRMVDAMLFVEEHGEVCPAGWNKGDEGM
EEECCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
KANAKGVAEYLAKNADKL
CCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLVTKPAPDFTAEAIKADGTFEDSFNLYKNIGKNGAVVFFWPKDFTFVCPSEIIAFDKRV
CCCCCCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEECCCCEEECCHHHHHHHHHH
KDFEARGVKVIGVSIDSKEVHFAWRNVPVNQGGIGAVTFPMVSDITKQISRDYDVLFNGA
HHHHHCCEEEEEEEECCCEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHCCCHHHEECCC
VALRGSFLIDKNKVVRHAVINDLPLGRNVDEMIRMVDAMLFVEEHGEVCPAGWNKGDEGM
EEECCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
KANAKGVAEYLAKNADKL
CCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]