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The map label for this gene is cad

Identifier: 32266665

GI number: 32266665

Start: 1132409

End: 1133500

Strand: Direct

Name: cad

Synonym: HH1166

Alternate gene names: 32266665

Gene position: 1132409-1133500 (Clockwise)

Preceding gene: 32266664

Following gene: 32266668

Centisome position: 62.94

GC content: 43.77

Gene sequence:

>1092_bases
ATGCTATTAAAAGAGAATTTGACACAAGCACAAAGTGGGCAGAGAATCACTGCCAAAGGCTACGCAGTCGCACATAAAAG
TGATACTTTTAAGCCCTTTAGTTTTTCGCGCCACGCTTTGGGAGAAACTGACATTTTGATTGAGATTCTATATGCTGGAA
TCTGCCATAGCGATATTCATAGCGCGCGTGAGGAATGGCATAAGGGAATTTTTCCAATGGTGCCCGGACACGAGATTGCG
GGTAAAGTCGTGGCAGTAGGAAGCAAGGTAAGCAAATTTAAAGTTGGCGATTACGCAGGGGTAGGCTGTATGGTCAATTC
TTGCGGTGAGTGTGAGGCGTGCAAAAGAAGCCAAGAGCAGTTTTGTGAAAATGGCAAATGCGTCTTTACTTATGATTGCC
ACGATTGCTTCCACGATAACGAGCCAACTTATGGCGGGTATTCAAATAATATTGTAGTGAGTGAAAAATTTGCGGTCAAT
GTCCCACAAGATGCGCCGTTAGAAAAAGTTGCTCCCTTGCTTTGCGCAGGAATCACCACCTATTCGCCGATTAAATTTAG
CAATGTCAAGGCAGGCGATAAAGTCGCGGTAGCTGGATTTGGTGGGCTTGGTGTAATGGCACTCAAATACGCAATCAAAA
TGGGTGCGGAAGTGAGCGTGTTTGCGCGTAATAAAAATAAAGAAAAAGAGGCATTAGATCTTGGTGCAAAGGCACTTTAT
ACTGATACAAAGGGTGTGAGCGAACGATTTGATTTTATCATTTCTACGATTCCAACCGCGTATGATGTGAATGCCTATGC
GGAGTTGTTGAAATTTGGCGGAGAAATGGCGATTGTCGGCTTACCACCTGCAGATGAGAAGCTTAGCATTGATTTAACGA
GACTTGTGTTTGCGGCGGGCAAAAAAGTCTATGGCTCACTCATTGGCGGAATAAAAGAGACACAAGAAATGCTTGATTTT
TCGCTCAAACATAGAATCTATCCCGAGACAGAGGTTATTTCTGTGGAGCAAATCAATGAGGCGTATGAGAATCTTACAAG
CGGCAAGGCGAAATTCCGCTATGTGATTGATATGAGCAGCCTCAAAGAATAA

Upstream 100 bases:

>100_bases
TTGTTGATATTTTTCGTTATTATGTGTATTGCCCCTTGACAAACACTAGGTATCAGGCTTTATAATTACATTTTCAATTT
TAGTCATTTAAGGAGTATTT

Downstream 100 bases:

>100_bases
GCAAATAAATAATTTATTACATTTGGAGAGCTAATTGTGTAAAAATCTCTCCTCTTTGTTTATAAGAGCTAAATTGATCT
AAGCTTGCAGCGGCAGGAGA

Product: putative NADP-dependent alcohol dehydrogenase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MLLKENLTQAQSGQRITAKGYAVAHKSDTFKPFSFSRHALGETDILIEILYAGICHSDIHSAREEWHKGIFPMVPGHEIA
GKVVAVGSKVSKFKVGDYAGVGCMVNSCGECEACKRSQEQFCENGKCVFTYDCHDCFHDNEPTYGGYSNNIVVSEKFAVN
VPQDAPLEKVAPLLCAGITTYSPIKFSNVKAGDKVAVAGFGGLGVMALKYAIKMGAEVSVFARNKNKEKEALDLGAKALY
TDTKGVSERFDFIISTIPTAYDVNAYAELLKFGGEMAIVGLPPADEKLSIDLTRLVFAAGKKVYGSLIGGIKETQEMLDF
SLKHRIYPETEVISVEQINEAYENLTSGKAKFRYVIDMSSLKE

Sequences:

>Translated_363_residues
MLLKENLTQAQSGQRITAKGYAVAHKSDTFKPFSFSRHALGETDILIEILYAGICHSDIHSAREEWHKGIFPMVPGHEIA
GKVVAVGSKVSKFKVGDYAGVGCMVNSCGECEACKRSQEQFCENGKCVFTYDCHDCFHDNEPTYGGYSNNIVVSEKFAVN
VPQDAPLEKVAPLLCAGITTYSPIKFSNVKAGDKVAVAGFGGLGVMALKYAIKMGAEVSVFARNKNKEKEALDLGAKALY
TDTKGVSERFDFIISTIPTAYDVNAYAELLKFGGEMAIVGLPPADEKLSIDLTRLVFAAGKKVYGSLIGGIKETQEMLDF
SLKHRIYPETEVISVEQINEAYENLTSGKAKFRYVIDMSSLKE
>Mature_363_residues
MLLKENLTQAQSGQRITAKGYAVAHKSDTFKPFSFSRHALGETDILIEILYAGICHSDIHSAREEWHKGIFPMVPGHEIA
GKVVAVGSKVSKFKVGDYAGVGCMVNSCGECEACKRSQEQFCENGKCVFTYDCHDCFHDNEPTYGGYSNNIVVSEKFAVN
VPQDAPLEKVAPLLCAGITTYSPIKFSNVKAGDKVAVAGFGGLGVMALKYAIKMGAEVSVFARNKNKEKEALDLGAKALY
TDTKGVSERFDFIISTIPTAYDVNAYAELLKFGGEMAIVGLPPADEKLSIDLTRLVFAAGKKVYGSLIGGIKETQEMLDF
SLKHRIYPETEVISVEQINEAYENLTSGKAKFRYVIDMSSLKE

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=373, Percent_Identity=27.6139410187668, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=27.3458445040214, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI156523966, Length=343, Percent_Identity=27.1137026239067, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=27.1137026239067, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71743840, Length=384, Percent_Identity=25.5208333333333, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4501929, Length=372, Percent_Identity=26.6129032258064, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI262073058, Length=381, Percent_Identity=26.246719160105, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71565154, Length=215, Percent_Identity=29.3023255813954, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI71565152, Length=348, Percent_Identity=25.5747126436782, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786518, Length=344, Percent_Identity=42.4418604651163, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI87082401, Length=347, Percent_Identity=31.4121037463977, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87081918, Length=343, Percent_Identity=29.7376093294461, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=27.5964391691395, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788073, Length=288, Percent_Identity=28.4722222222222, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786552, Length=354, Percent_Identity=27.1186440677966, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082125, Length=337, Percent_Identity=24.9258160237389, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI226510992, Length=258, Percent_Identity=25.5813953488372, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=320, Percent_Identity=30.3125, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17562584, Length=332, Percent_Identity=30.421686746988, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562582, Length=335, Percent_Identity=30.4477611940298, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25146526, Length=343, Percent_Identity=26.530612244898, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=345, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=341, Percent_Identity=26.9794721407625, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=228, Percent_Identity=28.9473684210526, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=204, Percent_Identity=31.3725490196078, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=352, Percent_Identity=32.3863636363636, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323980, Length=348, Percent_Identity=33.9080459770115, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6323961, Length=329, Percent_Identity=31.6109422492401, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324486, Length=329, Percent_Identity=30.6990881458967, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323729, Length=328, Percent_Identity=31.7073170731707, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319621, Length=332, Percent_Identity=30.421686746988, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320033, Length=380, Percent_Identity=28.6842105263158, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=231, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17737895, Length=351, Percent_Identity=26.2108262108262, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 39626; Mature: 39626

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKENLTQAQSGQRITAKGYAVAHKSDTFKPFSFSRHALGETDILIEILYAGICHSDIH
CCCHHHHHHHHCCCEEEECCEEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHH
SAREEWHKGIFPMVPGHEIAGKVVAVGSKVSKFKVGDYAGVGCMVNSCGECEACKRSQEQ
HHHHHHHCCCCCCCCCHHHCCEEEEECCCCCEEECCCCCCCHHHHCCCCCHHHHHHHHHH
FCENGKCVFTYDCHDCFHDNEPTYGGYSNNIVVSEKFAVNVPQDAPLEKVAPLLCAGITT
HHCCCCEEEEECHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCC
YSPIKFSNVKAGDKVAVAGFGGLGVMALKYAIKMGAEVSVFARNKNKEKEALDLGAKALY
CCCEEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCHHEE
TDTKGVSERFDFIISTIPTAYDVNAYAELLKFGGEMAIVGLPPADEKLSIDLTRLVFAAG
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEHHHHHHHHHHH
KKVYGSLIGGIKETQEMLDFSLKHRIYPETEVISVEQINEAYENLTSGKAKFRYVIDMSS
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHCCCEEEEEEEEHHH
LKE
HCC
>Mature Secondary Structure
MLLKENLTQAQSGQRITAKGYAVAHKSDTFKPFSFSRHALGETDILIEILYAGICHSDIH
CCCHHHHHHHHCCCEEEECCEEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHH
SAREEWHKGIFPMVPGHEIAGKVVAVGSKVSKFKVGDYAGVGCMVNSCGECEACKRSQEQ
HHHHHHHCCCCCCCCCHHHCCEEEEECCCCCEEECCCCCCCHHHHCCCCCHHHHHHHHHH
FCENGKCVFTYDCHDCFHDNEPTYGGYSNNIVVSEKFAVNVPQDAPLEKVAPLLCAGITT
HHCCCCEEEEECHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCC
YSPIKFSNVKAGDKVAVAGFGGLGVMALKYAIKMGAEVSVFARNKNKEKEALDLGAKALY
CCCEEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCHHEE
TDTKGVSERFDFIISTIPTAYDVNAYAELLKFGGEMAIVGLPPADEKLSIDLTRLVFAAG
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEHHHHHHHHHHH
KKVYGSLIGGIKETQEMLDFSLKHRIYPETEVISVEQINEAYENLTSGKAKFRYVIDMSS
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHCCCEEEEEEEEHHH
LKE
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]