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The map label for this gene is folK

Identifier: 32266641

GI number: 32266641

Start: 1108600

End: 1109127

Strand: Direct

Name: folK

Synonym: HH1142

Alternate gene names: 32266641

Gene position: 1108600-1109127 (Clockwise)

Preceding gene: 32266639

Following gene: 32266642

Centisome position: 61.62

GC content: 36.17

Gene sequence:

>528_bases
ATGGCATATAAAAGCGCACAGATTCTAAGCTCCAAGCATTATCCTTATAGGTTACACAAAAAGTTTCAAAAGCCCATTTC
TCCTAAGTATCGTAATATTTTTATGCTAGGTCTTGGTTCTAATCAGGGACTTTGCACTTTCCTCAATGAGAAAGGCAGTA
TTGCAATTTTAGAATCTGTATTTATGTGGTTTGATTCCTGCTCATATATAGAGATTCTCTGCACATCACCACTTTGGCGC
AATCCACCCTTTGGTTTTGAATCCCAAGATGATTTTTATAATGCAATTATGGTGTGTGGGAGCAATTTAAGTTTGGTAGA
AATTTATGGGCTTATTTTTTATATTGAACGTCGATTTGGGCGAGAACGCAAAAGAGCTTTTAAAAATGCCCCACGCACAC
TTGATATTGATATTATTTTTTTTAATGCGCTGCATATTAAGCGCCCTTATTTGCAAGTGCCTCATTCTTTTTACGATGTT
AGGGCTTCGGTAATGTTGCCTTTGAGCTTTATAGAAACATATATGTGA

Upstream 100 bases:

>100_bases
TATATTATGGTATTTTTTTTCATTGTATTGTCCTTTGAATGATATAAATTTGGGCTAAGATTTTATAATGTTTTCACAAA
CATAAAACCAAAGGCAGATA

Downstream 100 bases:

>100_bases
AAGTTTGTATCTTTGTGCAAGCAGTTAAACTTTACTAAAACATCAACAAGCTACAATAAGAATTTCTATTTTGAGCTTAT
AGGCGGATACGATGGCAAAA

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MAYKSAQILSSKHYPYRLHKKFQKPISPKYRNIFMLGLGSNQGLCTFLNEKGSIAILESVFMWFDSCSYIEILCTSPLWR
NPPFGFESQDDFYNAIMVCGSNLSLVEIYGLIFYIERRFGRERKRAFKNAPRTLDIDIIFFNALHIKRPYLQVPHSFYDV
RASVMLPLSFIETYM

Sequences:

>Translated_175_residues
MAYKSAQILSSKHYPYRLHKKFQKPISPKYRNIFMLGLGSNQGLCTFLNEKGSIAILESVFMWFDSCSYIEILCTSPLWR
NPPFGFESQDDFYNAIMVCGSNLSLVEIYGLIFYIERRFGRERKRAFKNAPRTLDIDIIFFNALHIKRPYLQVPHSFYDV
RASVMLPLSFIETYM
>Mature_174_residues
AYKSAQILSSKHYPYRLHKKFQKPISPKYRNIFMLGLGSNQGLCTFLNEKGSIAILESVFMWFDSCSYIEILCTSPLWRN
PPFGFESQDDFYNAIMVCGSNLSLVEIYGLIFYIERRFGRERKRAFKNAPRTLDIDIIFFNALHIKRPYLQVPHSFYDVR
ASVMLPLSFIETYM

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 20541; Mature: 20410

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00092 N6_MTASE ; PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYKSAQILSSKHYPYRLHKKFQKPISPKYRNIFMLGLGSNQGLCTFLNEKGSIAILESV
CCCCCCHHHHCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHH
FMWFDSCSYIEILCTSPLWRNPPFGFESQDDFYNAIMVCGSNLSLVEIYGLIFYIERRFG
HHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
RERKRAFKNAPRTLDIDIIFFNALHIKRPYLQVPHSFYDVRASVMLPLSFIETYM
HHHHHHHHCCCCEEEEEEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AYKSAQILSSKHYPYRLHKKFQKPISPKYRNIFMLGLGSNQGLCTFLNEKGSIAILESV
CCCCCHHHHCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHH
FMWFDSCSYIEILCTSPLWRNPPFGFESQDDFYNAIMVCGSNLSLVEIYGLIFYIERRFG
HHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
RERKRAFKNAPRTLDIDIIFFNALHIKRPYLQVPHSFYDVRASVMLPLSFIETYM
HHHHHHHHCCCCEEEEEEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]