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The map label for this gene is aroC

Identifier: 32266199

GI number: 32266199

Start: 679580

End: 680656

Strand: Direct

Name: aroC

Synonym: HH0700

Alternate gene names: 32266199

Gene position: 679580-680656 (Clockwise)

Preceding gene: 32266198

Following gene: 32266200

Centisome position: 37.77

GC content: 40.67

Gene sequence:

>1077_bases
ATGAATACTTTTGGCAAATCATTTCGTGTAAGCACTTTTGGAGAATCTCACGGCGAGGGGATTGGTTGTGTGATTGATGG
CATTCCTGCAGGATTGCATATAGATGAACTTTTTATAGAATCTATGATGACAAGGCGCGCACCCGGACGCAATCAATATA
CAACACAACGTAAAGAATCTGATAAAGTGCAAATTCTAAGTGGTGTGTTTGAAGGGTTGAGCACGGGCACACCTATTGGT
ATGTGGATAGCAAATACTGGAACAAAAAGCAGTGATTACGCCAATATTAAAGACATTTTTCGTCCCGGACACGCTGATTA
TACATATTTCAAAAAATATGGTATCCGAGATTATAGAGGGGGAGGAAGAAGTTCAGCAAGAGAAAGTGTAGCAAGAGTAG
CAGCTGGAGCTGTAGCACAAATGCTTTTGCGCGAATTTGACATAAATGTCCAAAGTGGCATATGCTCAATTGGCAATATC
ACAGGGAAGCAATATGATTTTGCATACGCACTCAAAAGTGAAATTTATGCACTTGACAAAGAATGTGAAGAATCACAAAA
AGCGCTTATTGAAAATGCTAAAAGAAAACACGATAGCATTGGTGGAAGTGCTCTCATTCGTGTAGAGGGACTTCCTGCAG
GATTGGGCGAACCACTTTATCATCGCCTCGATGGAGCGTTGGGAGAAGCACTTATGGGGCTTAATGCTGTTAAAGCGGTA
GAAATAGGCGATGGAATCATCTCTTGCACCCAATATGGAAGTGAGCATAATGACCAAATGGATAAAAACGGCTTTAAAAG
TAACCATAGTGGTGGTATTTTGGGAGGTATAAGTAATGGCAATGCACTTCTTGTTAAAGCACATTTCAAACCTACACCGA
GTATTTTTATACCCCAAGAGACGCTTGATATACACTTACAAGAACAAACTTGCCAAATCAAAGGACGACACGACCCGTGT
GTAGCAGTTCGTGGCAGTATAGTCGCGCAAGCAATGGTTGCTCTCGTCCTCGCAGATATGCTTTTATTACACGCTACTTC
ACAACTTTGTTTTTTAAAAAAGATTTATAAGCAATAA

Upstream 100 bases:

>100_bases
CAAGCGGGAACTCAAAAAAAGAGGCGCAACAAAAAAGCGCGCAAATTGCTTATAAAAAACTCTATTCAAAGATGAATAAA
ACTCATCATAAAGGGGAAAA

Downstream 100 bases:

>100_bases
CAAAATTTATATTATAGTTATTTTAAAGCAAGAAGATTCTATAATCACACTTCCTTAACACAATAGGAGACAATAAATGA
TAACACTCAAAGAAGCTCTA

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MNTFGKSFRVSTFGESHGEGIGCVIDGIPAGLHIDELFIESMMTRRAPGRNQYTTQRKESDKVQILSGVFEGLSTGTPIG
MWIANTGTKSSDYANIKDIFRPGHADYTYFKKYGIRDYRGGGRSSARESVARVAAGAVAQMLLREFDINVQSGICSIGNI
TGKQYDFAYALKSEIYALDKECEESQKALIENAKRKHDSIGGSALIRVEGLPAGLGEPLYHRLDGALGEALMGLNAVKAV
EIGDGIISCTQYGSEHNDQMDKNGFKSNHSGGILGGISNGNALLVKAHFKPTPSIFIPQETLDIHLQEQTCQIKGRHDPC
VAVRGSIVAQAMVALVLADMLLLHATSQLCFLKKIYKQ

Sequences:

>Translated_358_residues
MNTFGKSFRVSTFGESHGEGIGCVIDGIPAGLHIDELFIESMMTRRAPGRNQYTTQRKESDKVQILSGVFEGLSTGTPIG
MWIANTGTKSSDYANIKDIFRPGHADYTYFKKYGIRDYRGGGRSSARESVARVAAGAVAQMLLREFDINVQSGICSIGNI
TGKQYDFAYALKSEIYALDKECEESQKALIENAKRKHDSIGGSALIRVEGLPAGLGEPLYHRLDGALGEALMGLNAVKAV
EIGDGIISCTQYGSEHNDQMDKNGFKSNHSGGILGGISNGNALLVKAHFKPTPSIFIPQETLDIHLQEQTCQIKGRHDPC
VAVRGSIVAQAMVALVLADMLLLHATSQLCFLKKIYKQ
>Mature_358_residues
MNTFGKSFRVSTFGESHGEGIGCVIDGIPAGLHIDELFIESMMTRRAPGRNQYTTQRKESDKVQILSGVFEGLSTGTPIG
MWIANTGTKSSDYANIKDIFRPGHADYTYFKKYGIRDYRGGGRSSARESVARVAAGAVAQMLLREFDINVQSGICSIGNI
TGKQYDFAYALKSEIYALDKECEESQKALIENAKRKHDSIGGSALIRVEGLPAGLGEPLYHRLDGALGEALMGLNAVKAV
EIGDGIISCTQYGSEHNDQMDKNGFKSNHSGGILGGISNGNALLVKAHFKPTPSIFIPQETLDIHLQEQTCQIKGRHDPC
VAVRGSIVAQAMVALVLADMLLLHATSQLCFLKKIYKQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=342, Percent_Identity=49.4152046783626, Blast_Score=327, Evalue=6e-91,
Organism=Saccharomyces cerevisiae, GI6321290, Length=365, Percent_Identity=38.6301369863014, Blast_Score=258, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_HELHP (Q7VIA8)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860231.1
- ProteinModelPortal:   Q7VIA8
- SMR:   Q7VIA8
- GeneID:   1493754
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0700
- NMPDR:   fig|235279.1.peg.700
- HOGENOM:   HBG292336
- OMA:   SRFTTQR
- ProtClustDB:   PRK05382
- BioCyc:   HHEP235279:HH_0700-MONOMER
- BRENDA:   4.2.3.5
- HAMAP:   MF_00300_B
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 38836; Mature: 38836

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFGKSFRVSTFGESHGEGIGCVIDGIPAGLHIDELFIESMMTRRAPGRNQYTTQRKES
CCCCCCCCEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DKVQILSGVFEGLSTGTPIGMWIANTGTKSSDYANIKDIFRPGHADYTYFKKYGIRDYRG
CHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCCCC
GGRSSARESVARVAAGAVAQMLLREFDINVQSGICSIGNITGKQYDFAYALKSEIYALDK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEECCCCCCCCCHHHHHHHHHHHHHHH
ECEESQKALIENAKRKHDSIGGSALIRVEGLPAGLGEPLYHRLDGALGEALMGLNAVKAV
HHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHEEE
EIGDGIISCTQYGSEHNDQMDKNGFKSNHSGGILGGISNGNALLVKAHFKPTPSIFIPQE
ECCCCHHHHHHCCCCCCCCHHCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCEEECCH
TLDIHLQEQTCQIKGRHDPCVAVRGSIVAQAMVALVLADMLLLHATSQLCFLKKIYKQ
HEEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTFGKSFRVSTFGESHGEGIGCVIDGIPAGLHIDELFIESMMTRRAPGRNQYTTQRKES
CCCCCCCCEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DKVQILSGVFEGLSTGTPIGMWIANTGTKSSDYANIKDIFRPGHADYTYFKKYGIRDYRG
CHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCCCC
GGRSSARESVARVAAGAVAQMLLREFDINVQSGICSIGNITGKQYDFAYALKSEIYALDK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEECCCCCCCCCHHHHHHHHHHHHHHH
ECEESQKALIENAKRKHDSIGGSALIRVEGLPAGLGEPLYHRLDGALGEALMGLNAVKAV
HHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHEEE
EIGDGIISCTQYGSEHNDQMDKNGFKSNHSGGILGGISNGNALLVKAHFKPTPSIFIPQE
ECCCCHHHHHHCCCCCCCCHHCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCEEECCH
TLDIHLQEQTCQIKGRHDPCVAVRGSIVAQAMVALVLADMLLLHATSQLCFLKKIYKQ
HEEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954