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The map label for this gene is rnc

Identifier: 32266198

GI number: 32266198

Start: 678861

End: 679583

Strand: Direct

Name: rnc

Synonym: HH0699

Alternate gene names: 32266198

Gene position: 678861-679583 (Clockwise)

Preceding gene: 32266197

Following gene: 32266199

Centisome position: 37.73

GC content: 33.75

Gene sequence:

>723_bases
ATGAGTAAATCTATTTTGCCCAAATCTCCCCAGCTCCTTGAGAAAAAGTTAGGCTATGTTTTTCAAAATCAACAACTCCT
CCTTGAAGCCCTCACGCATAAAAGTTGTAAAAAACAATATAATAACGAACGACTTGAGTTTCTAGGAGATGCAGTGCTAG
ATTTGCTTGTAGGAGAATATTTATTTAAAAAATTCCCTCTTGCTAAAGAAGGTGAGTTATCTAAATTACGAGCGTGCATC
GTCAATGAGAAAGGTTTTATGAAACTTGCTCAATCACTTGATTTAGGTGCATATTTATATATCTCACAAAGTGAAGAAAA
CAACAATGGACGGCAAAAAGCTTCCATTTTATCTAATGCCTTTGAAGCCCTCATAGGTGCAATTTATTTAGAATCTAGCC
TCACTTATGTTCAAAGTATTATTTATGATTTACTTGAATATAATTATATCAAGATTGATTTAGATTCTCTTTTTATGGAT
TATAAAACTGCGCTACAAGAGATTACTCAAGCTTTTTATGGTGAGATTCCAACTTATACGCTCATTAGCGAAAGCGGACC
CGATCATAAAAAAAGTTTTGAAATAGCTCTAAGTGTGCAAGGAAAAGAATATGCAAGAGCAAGCGGGAACTCAAAAAAAG
AGGCGCAACAAAAAAGCGCGCAAATTGCTTATAAAAAACTCTATTCAAAGATGAATAAAACTCATCATAAAGGGGAAAAA
TGA

Upstream 100 bases:

>100_bases
GCACATTGGGTAAAAGGACACGCGGGAGTAGCACAAAATGAACTATGTGATAAACTTGCAAAAGAAAGTGCGCAATTTTA
TTTAAATAAAGGAATTTCTG

Downstream 100 bases:

>100_bases
ATACTTTTGGCAAATCATTTCGTGTAAGCACTTTTGGAGAATCTCACGGCGAGGGGATTGGTTGTGTGATTGATGGCATT
CCTGCAGGATTGCATATAGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSKSILPKSPQLLEKKLGYVFQNQQLLLEALTHKSCKKQYNNERLEFLGDAVLDLLVGEYLFKKFPLAKEGELSKLRACI
VNEKGFMKLAQSLDLGAYLYISQSEENNNGRQKASILSNAFEALIGAIYLESSLTYVQSIIYDLLEYNYIKIDLDSLFMD
YKTALQEITQAFYGEIPTYTLISESGPDHKKSFEIALSVQGKEYARASGNSKKEAQQKSAQIAYKKLYSKMNKTHHKGEK

Sequences:

>Translated_240_residues
MSKSILPKSPQLLEKKLGYVFQNQQLLLEALTHKSCKKQYNNERLEFLGDAVLDLLVGEYLFKKFPLAKEGELSKLRACI
VNEKGFMKLAQSLDLGAYLYISQSEENNNGRQKASILSNAFEALIGAIYLESSLTYVQSIIYDLLEYNYIKIDLDSLFMD
YKTALQEITQAFYGEIPTYTLISESGPDHKKSFEIALSVQGKEYARASGNSKKEAQQKSAQIAYKKLYSKMNKTHHKGEK
>Mature_239_residues
SKSILPKSPQLLEKKLGYVFQNQQLLLEALTHKSCKKQYNNERLEFLGDAVLDLLVGEYLFKKFPLAKEGELSKLRACIV
NEKGFMKLAQSLDLGAYLYISQSEENNNGRQKASILSNAFEALIGAIYLESSLTYVQSIIYDLLEYNYIKIDLDSLFMDY
KTALQEITQAFYGEIPTYTLISESGPDHKKSFEIALSVQGKEYARASGNSKKEAQQKSAQIAYKKLYSKMNKTHHKGEK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=249, Percent_Identity=26.9076305220884, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI155030236, Length=249, Percent_Identity=26.9076305220884, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1788920, Length=216, Percent_Identity=36.5740740740741, Blast_Score=138, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17506883, Length=236, Percent_Identity=27.5423728813559, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI193202651, Length=236, Percent_Identity=27.5423728813559, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17137682, Length=221, Percent_Identity=28.5067873303167, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_HELHP (Q7VIA9)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860230.1
- ProteinModelPortal:   Q7VIA9
- SMR:   Q7VIA9
- GeneID:   1493753
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0699
- NMPDR:   fig|235279.1.peg.699
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   HHEP235279:HH_0699-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27284; Mature: 27152

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSILPKSPQLLEKKLGYVFQNQQLLLEALTHKSCKKQYNNERLEFLGDAVLDLLVGEY
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LFKKFPLAKEGELSKLRACIVNEKGFMKLAQSLDLGAYLYISQSEENNNGRQKASILSNA
HHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHH
FEALIGAIYLESSLTYVQSIIYDLLEYNYIKIDLDSLFMDYKTALQEITQAFYGEIPTYT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEE
LISESGPDHKKSFEIALSVQGKEYARASGNSKKEAQQKSAQIAYKKLYSKMNKTHHKGEK
EEECCCCCCCCCEEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKSILPKSPQLLEKKLGYVFQNQQLLLEALTHKSCKKQYNNERLEFLGDAVLDLLVGEY
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LFKKFPLAKEGELSKLRACIVNEKGFMKLAQSLDLGAYLYISQSEENNNGRQKASILSNA
HHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHH
FEALIGAIYLESSLTYVQSIIYDLLEYNYIKIDLDSLFMDYKTALQEITQAFYGEIPTYT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEE
LISESGPDHKKSFEIALSVQGKEYARASGNSKKEAQQKSAQIAYKKLYSKMNKTHHKGEK
EEECCCCCCCCCEEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954