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The map label for this gene is ureI

Identifier: 32265908

GI number: 32265908

Start: 394347

End: 394859

Strand: Direct

Name: ureI

Synonym: HH0409

Alternate gene names: 32265908

Gene position: 394347-394859 (Clockwise)

Preceding gene: 32265907

Following gene: 161546633

Centisome position: 21.92

GC content: 36.45

Gene sequence:

>513_bases
ATGCTAGGAATTGTATTAATGTATGTAGCTATTGTTTTAATTAATAATGGTATTTGCCGCCTCACTCATATTGATGGAAA
AAGTGCTTCAATAATGAATATCTTTGTAGGATTGCTCTCTGTGCTTGTAAATCTTATTGTCATTGTGCACGGAAGCATTA
ACAGCGAGTATAATGACTTTTATGCAGCTGCAACAGGATTACTTTTTGGCTTTACCTATCTTTTTATAGCGTGCAATAAT
TTATTTAATCTTGATATAAGAGCCTATGGGTGGTATAGTTTATTTGTTGCCATCAATGCTATTCCCGCAGCCTATTTGAG
CTATCTTGAAAACACACAAGAAGGTATGGCATTTGCTCTTATATGGATTGCTTGGGGCATTTTATGGCTTACAGGCTGGA
TTGAAAGTATTTTAAAAATTGAACTCAAATTTGTGCCTTATTTAGCCATTGCCGAGGGAATCCTCACCGCGTGGATTCCA
GCGTGGCTTATCCTTATGGGATATTGGCATTAA

Upstream 100 bases:

>100_bases
AGAAACTTATGAAGTAAGAGTAAATAATACAAAAATTACTTCTAAGCCTGTTGAAAAGGTATCTTTAGGGCAACTTTATT
GTTTATTTTAAGGAGAAAAT

Downstream 100 bases:

>100_bases
TGCGAGTAGAACACATTATTGGTAATATCAAAGACATAGATGCGACGCATTTAGACATTGATGAAGTGCAAATAGCTTGG
TATGACACAAAGAAAAAAAT

Product: urease accessory protein UreI

Products: NA

Alternate protein names: Urease accessory protein ureI [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MLGIVLMYVAIVLINNGICRLTHIDGKSASIMNIFVGLLSVLVNLIVIVHGSINSEYNDFYAAATGLLFGFTYLFIACNN
LFNLDIRAYGWYSLFVAINAIPAAYLSYLENTQEGMAFALIWIAWGILWLTGWIESILKIELKFVPYLAIAEGILTAWIP
AWLILMGYWH

Sequences:

>Translated_170_residues
MLGIVLMYVAIVLINNGICRLTHIDGKSASIMNIFVGLLSVLVNLIVIVHGSINSEYNDFYAAATGLLFGFTYLFIACNN
LFNLDIRAYGWYSLFVAINAIPAAYLSYLENTQEGMAFALIWIAWGILWLTGWIESILKIELKFVPYLAIAEGILTAWIP
AWLILMGYWH
>Mature_170_residues
MLGIVLMYVAIVLINNGICRLTHIDGKSASIMNIFVGLLSVLVNLIVIVHGSINSEYNDFYAAATGLLFGFTYLFIACNN
LFNLDIRAYGWYSLFVAINAIPAAYLSYLENTQEGMAFALIWIAWGILWLTGWIESILKIELKFVPYLAIAEGILTAWIP
AWLILMGYWH

Specific function: Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AmiS/UreI family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003211 [H]

Pfam domain/function: PF02293 AmiS_UreI [H]

EC number: NA

Molecular weight: Translated: 19090; Mature: 19090

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIVLMYVAIVLINNGICRLTHIDGKSASIMNIFVGLLSVLVNLIVIVHGSINSEYNDF
CHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YAAATGLLFGFTYLFIACNNLFNLDIRAYGWYSLFVAINAIPAAYLSYLENTQEGMAFAL
HHHHHHHHHHHHHHHHHHCCCEECEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWIAWGILWLTGWIESILKIELKFVPYLAIAEGILTAWIPAWLILMGYWH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLGIVLMYVAIVLINNGICRLTHIDGKSASIMNIFVGLLSVLVNLIVIVHGSINSEYNDF
CHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YAAATGLLFGFTYLFIACNNLFNLDIRAYGWYSLFVAINAIPAAYLSYLENTQEGMAFAL
HHHHHHHHHHHHHHHHHHCCCEECEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWIAWGILWLTGWIESILKIELKFVPYLAIAEGILTAWIPAWLILMGYWH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]