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The map label for this gene is fcl [H]

Identifier: 32265672

GI number: 32265672

Start: 166657

End: 167700

Strand: Direct

Name: fcl [H]

Synonym: HH0173

Alternate gene names: 32265672

Gene position: 166657-167700 (Clockwise)

Preceding gene: 32265671

Following gene: 32265678

Centisome position: 9.26

GC content: 35.44

Gene sequence:

>1044_bases
ATGCAAAAAGATTCTAAAATCTATGTTGCAGGGCATAGGGGACTTGTGGGGAGTGCAATTTATAGAGAACTTCAAAATCA
AGGTTATACTAATTTACTGATTAAAACCCATAAAGAGCTAGATTTGACACAATCGGAGTGTGTGAGTGCATTTTTTGCCA
AAGAGCAGCCTGAATATGTATTTTTATGTGCGGCAAAAGTGGGTGGGATTCTAGCAAATAACACTTATAGAGCGGAATTT
ATTTATGAAAATCTTGCCATTCAAAATAATATTATCCACAATGCGTATATAAGTGGTGTGAAAAAAATGCTTTTTCTTGG
CTCAACTTGCATTTATCCCAAAAATGCCCCGCAACCCATTTCTGAAGATTCTTTACTCACAAGCGAGCTAGAATACACTA
ATGAACCTTATGCGATTGCCAAAATTGCAGGACTTAAAATGTGCGAATCTTATAATCTCCAATATGGCACAAATTTTATT
TGCGCAATGCCAACAAATCTTTATGGCGAAAATGATAATTTTGACTTGGAAAAATCTCACGTTCTCCCGGCTCTTTTGCG
TAAATTTCATTTAGCAAAGCTCTTATCTCAAAATAAACTCCAAGAAATAATGCAAAATCTTGGCTTTAATGATGAGACAA
CAACACTAGCATATCTCCAAAGATTTGGCATAAGCGCAGAACGTATAGAAATATGGGGAAGTGGCAATCCCAAAAGGGAA
TTTTTATATGTGCAGGATTTGGCAAACGCGTGCGTGTTTATTATGCAAAATTTAAACTTTAAAGATTTATATGCCAAAGA
TTCTACACAAATCCGCAATACGCAGATTAATATCGGCACAGGCGAGGATATTTCTATCAAAGATTTAGCGTATTTAATCA
AAGAGATTGTGGGCTTTAAAGGGGAGATTTGCTTTGATACTAGCAAACCCGATGGCACAATGCGCAAATTAAGCGATGTA
AGCAAAATCCAAACTTTGGGTTGGAAACATACATATTCGCTCAAAGAAGGAATTTTAAAGACATATCAAAAAGTCTTTAA
ATAA

Upstream 100 bases:

>100_bases
GATTTAAAACTAATGCGCAAAGATGTGTATCTCAAAGAAGGTGGATACAAAATTATGCGGTATTTTGAATAATGAAGATT
TTAATCATATAAGGAAGCAA

Downstream 100 bases:

>100_bases
TTTAGCTCATTTTATTTTTAAGCCATTGACTTAACCTTGCAATATAACTCCAAAAGAGCGGAATAAAAAATATTGCTATA
AATGTTGCCGCCATCATTCC

Product: hypothetical protein

Products: NA

Alternate protein names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MQKDSKIYVAGHRGLVGSAIYRELQNQGYTNLLIKTHKELDLTQSECVSAFFAKEQPEYVFLCAAKVGGILANNTYRAEF
IYENLAIQNNIIHNAYISGVKKMLFLGSTCIYPKNAPQPISEDSLLTSELEYTNEPYAIAKIAGLKMCESYNLQYGTNFI
CAMPTNLYGENDNFDLEKSHVLPALLRKFHLAKLLSQNKLQEIMQNLGFNDETTTLAYLQRFGISAERIEIWGSGNPKRE
FLYVQDLANACVFIMQNLNFKDLYAKDSTQIRNTQINIGTGEDISIKDLAYLIKEIVGFKGEICFDTSKPDGTMRKLSDV
SKIQTLGWKHTYSLKEGILKTYQKVFK

Sequences:

>Translated_347_residues
MQKDSKIYVAGHRGLVGSAIYRELQNQGYTNLLIKTHKELDLTQSECVSAFFAKEQPEYVFLCAAKVGGILANNTYRAEF
IYENLAIQNNIIHNAYISGVKKMLFLGSTCIYPKNAPQPISEDSLLTSELEYTNEPYAIAKIAGLKMCESYNLQYGTNFI
CAMPTNLYGENDNFDLEKSHVLPALLRKFHLAKLLSQNKLQEIMQNLGFNDETTTLAYLQRFGISAERIEIWGSGNPKRE
FLYVQDLANACVFIMQNLNFKDLYAKDSTQIRNTQINIGTGEDISIKDLAYLIKEIVGFKGEICFDTSKPDGTMRKLSDV
SKIQTLGWKHTYSLKEGILKTYQKVFK
>Mature_347_residues
MQKDSKIYVAGHRGLVGSAIYRELQNQGYTNLLIKTHKELDLTQSECVSAFFAKEQPEYVFLCAAKVGGILANNTYRAEF
IYENLAIQNNIIHNAYISGVKKMLFLGSTCIYPKNAPQPISEDSLLTSELEYTNEPYAIAKIAGLKMCESYNLQYGTNFI
CAMPTNLYGENDNFDLEKSHVLPALLRKFHLAKLLSQNKLQEIMQNLGFNDETTTLAYLQRFGISAERIEIWGSGNPKRE
FLYVQDLANACVFIMQNLNFKDLYAKDSTQIRNTQINIGTGEDISIKDLAYLIKEIVGFKGEICFDTSKPDGTMRKLSDV
SKIQTLGWKHTYSLKEGILKTYQKVFK

Specific function: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=327, Percent_Identity=30.8868501529052, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1788365, Length=338, Percent_Identity=49.7041420118343, Blast_Score=340, Evalue=8e-95,
Organism=Caenorhabditis elegans, GI17554428, Length=323, Percent_Identity=27.2445820433437, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI19922778, Length=323, Percent_Identity=26.625386996904, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.271 [H]

Molecular weight: Translated: 39357; Mature: 39357

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKDSKIYVAGHRGLVGSAIYRELQNQGYTNLLIKTHKELDLTQSECVSAFFAKEQPEYV
CCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEE
FLCAAKVGGILANNTYRAEFIYENLAIQNNIIHNAYISGVKKMLFLGSTCIYPKNAPQPI
EEEEHHHCCEEECCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCC
SEDSLLTSELEYTNEPYAIAKIAGLKMCESYNLQYGTNFICAMPTNLYGENDNFDLEKSH
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHH
VLPALLRKFHLAKLLSQNKLQEIMQNLGFNDETTTLAYLQRFGISAERIEIWGSGNPKRE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHH
FLYVQDLANACVFIMQNLNFKDLYAKDSTQIRNTQINIGTGEDISIKDLAYLIKEIVGFK
EEEHHHHHHHHHHHHHCCCHHHHCCCCCCEEECEEEEECCCCCCCHHHHHHHHHHHHCCC
GEICFDTSKPDGTMRKLSDVSKIQTLGWKHTYSLKEGILKTYQKVFK
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MQKDSKIYVAGHRGLVGSAIYRELQNQGYTNLLIKTHKELDLTQSECVSAFFAKEQPEYV
CCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEE
FLCAAKVGGILANNTYRAEFIYENLAIQNNIIHNAYISGVKKMLFLGSTCIYPKNAPQPI
EEEEHHHCCEEECCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCC
SEDSLLTSELEYTNEPYAIAKIAGLKMCESYNLQYGTNFICAMPTNLYGENDNFDLEKSH
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHH
VLPALLRKFHLAKLLSQNKLQEIMQNLGFNDETTTLAYLQRFGISAERIEIWGSGNPKRE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHH
FLYVQDLANACVFIMQNLNFKDLYAKDSTQIRNTQINIGTGEDISIKDLAYLIKEIVGFK
EEEHHHHHHHHHHHHHCCCHHHHCCCCCCEEECEEEEECCCCCCCHHHHHHHHHHHHCCC
GEICFDTSKPDGTMRKLSDVSKIQTLGWKHTYSLKEGILKTYQKVFK
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7815923; 8759852; 9097040; 9278503; 9473059; 9862812 [H]