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The map label for this gene is argB

Identifier: 32265678

GI number: 32265678

Start: 174324

End: 175166

Strand: Direct

Name: argB

Synonym: HH0179

Alternate gene names: 32265678

Gene position: 174324-175166 (Clockwise)

Preceding gene: 32265672

Following gene: 32265679

Centisome position: 9.69

GC content: 37.01

Gene sequence:

>843_bases
GTGAAAATATTACTAGATTCACTCCCATTTATTAGAATCTTTCGCGGGCAAATCATTGTTATTAAATATGGCGGTGCAGC
TCAAATCAATCCACAGCTCAAAGAAAAATTTGCCCTTGATATTGTCATAATGTATATGCTTGGCTTAAAGCCTGTAATTA
TACACGGTGGAGGAAAACGCATTAATGAAATGCTTGATATTATGGGCATAGAAAGTGAATTTTATAATGGTTATCGCATA
ACAAGTGCTGAATGTATGCGCGTGGTAGAAATGGTGCTAAGTGGGGAGATTAATAAAGAATTAACTGCTTTTTTGAATTT
TCACGGCGCAAAAGCTGTGGGTATGAGCGGCAAAGATGCACATTTACTTCAAGCAAAAGCAAAAGATAATGGTGCTCTTG
GTTATACTGGTGAGATTACAGCAGTCAATCCTAGTTTTTTGCTCAATGTTATTAATGATGGTTTTGTGCCAATTATTGCG
CCTATTGCTACAGGAGAGGGTGCGGGACATTTGGGCTATAATATTAATGCTGATATTGCTGCGTGCCATATAGCCAAAGC
CTTGAGTGCAAAAAAAATTATTTTTCTTAGCGATATTGCAGGTGTGCTAGATAGCAACAAAGAACCTATTTCTTCGCTTA
CCCCCTCTGATATAAAACAACTTCAAAAACAAGGTGTAATTAATGGCGGTATGATACCTAAACTTGAAGCGTGTGTAGAT
TGTGTGCAAAATGGTGTAGAAAAAGCTCATATTATTGATGGACGCATAGAGCATTCGCTTTTATTAGAACTTTTTACCAC
GCAAGGTATAGGTACAGAAATTTACAATGGACAGGATAAATGA

Upstream 100 bases:

>100_bases
GTATAACCATCTTCATCACTTGTCCTTTATTTAGATTTTAAGATATAATAACATTTCATTTTTGAATAAGGCGCAAAATA
TGCAAAAAAATGCAAGAGTT

Downstream 100 bases:

>100_bases
CACTCCAATCTTATAAATATAGCTTTTTAGAGCGATTATGGCTCAAACTTGAAGCACATTCGGCAGATAAAAATACAGAA
AATATTGTGATGATTTTACC

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKILLDSLPFIRIFRGQIIVIKYGGAAQINPQLKEKFALDIVIMYMLGLKPVIIHGGGKRINEMLDIMGIESEFYNGYRI
TSAECMRVVEMVLSGEINKELTAFLNFHGAKAVGMSGKDAHLLQAKAKDNGALGYTGEITAVNPSFLLNVINDGFVPIIA
PIATGEGAGHLGYNINADIAACHIAKALSAKKIIFLSDIAGVLDSNKEPISSLTPSDIKQLQKQGVINGGMIPKLEACVD
CVQNGVEKAHIIDGRIEHSLLLELFTTQGIGTEIYNGQDK

Sequences:

>Translated_280_residues
MKILLDSLPFIRIFRGQIIVIKYGGAAQINPQLKEKFALDIVIMYMLGLKPVIIHGGGKRINEMLDIMGIESEFYNGYRI
TSAECMRVVEMVLSGEINKELTAFLNFHGAKAVGMSGKDAHLLQAKAKDNGALGYTGEITAVNPSFLLNVINDGFVPIIA
PIATGEGAGHLGYNINADIAACHIAKALSAKKIIFLSDIAGVLDSNKEPISSLTPSDIKQLQKQGVINGGMIPKLEACVD
CVQNGVEKAHIIDGRIEHSLLLELFTTQGIGTEIYNGQDK
>Mature_280_residues
MKILLDSLPFIRIFRGQIIVIKYGGAAQINPQLKEKFALDIVIMYMLGLKPVIIHGGGKRINEMLDIMGIESEFYNGYRI
TSAECMRVVEMVLSGEINKELTAFLNFHGAKAVGMSGKDAHLLQAKAKDNGALGYTGEITAVNPSFLLNVINDGFVPIIA
PIATGEGAGHLGYNINADIAACHIAKALSAKKIIFLSDIAGVLDSNKEPISSLTPSDIKQLQKQGVINGGMIPKLEACVD
CVQNGVEKAHIIDGRIEHSLLLELFTTQGIGTEIYNGQDK

Specific function: Arginine biosynthesis; second step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI145693208, Length=257, Percent_Identity=28.7937743190661, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789181, Length=282, Percent_Identity=26.5957446808511, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320913, Length=273, Percent_Identity=30.4029304029304, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGB_HELHP (Q7VJR4)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_859710.1
- ProteinModelPortal:   Q7VJR4
- SMR:   Q7VJR4
- GeneID:   1493234
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0179
- NMPDR:   fig|235279.1.peg.179
- HOGENOM:   HBG497643
- OMA:   MDIVEMV
- ProtClustDB:   PRK00942
- BioCyc:   HHEP235279:HH_0179-MONOMER
- BRENDA:   2.7.2.8
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR001057
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- PRINTS:   PR00474
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 30191; Mature: 30191

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLDSLPFIRIFRGQIIVIKYGGAAQINPQLKEKFALDIVIMYMLGLKPVIIHGGGKR
CEEECCCCCCEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
INEMLDIMGIESEFYNGYRITSAECMRVVEMVLSGEINKELTAFLNFHGAKAVGMSGKDA
HHHHHHHHCCHHHHCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEECCCCCCC
HLLQAKAKDNGALGYTGEITAVNPSFLLNVINDGFVPIIAPIATGEGAGHLGYNINADIA
CEEEEECCCCCCCCCCCEEEEECHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHH
ACHIAKALSAKKIIFLSDIAGVLDSNKEPISSLTPSDIKQLQKQGVINGGMIPKLEACVD
HHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
CVQNGVEKAHIIDGRIEHSLLLELFTTQGIGTEIYNGQDK
HHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKILLDSLPFIRIFRGQIIVIKYGGAAQINPQLKEKFALDIVIMYMLGLKPVIIHGGGKR
CEEECCCCCCEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
INEMLDIMGIESEFYNGYRITSAECMRVVEMVLSGEINKELTAFLNFHGAKAVGMSGKDA
HHHHHHHHCCHHHHCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEECCCCCCC
HLLQAKAKDNGALGYTGEITAVNPSFLLNVINDGFVPIIAPIATGEGAGHLGYNINADIA
CEEEEECCCCCCCCCCCEEEEECHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHH
ACHIAKALSAKKIIFLSDIAGVLDSNKEPISSLTPSDIKQLQKQGVINGGMIPKLEACVD
HHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
CVQNGVEKAHIIDGRIEHSLLLELFTTQGIGTEIYNGQDK
HHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954