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The map label for this gene is zraS [H]

Identifier: 32265520

GI number: 32265520

Start: 22148

End: 23623

Strand: Direct

Name: zraS [H]

Synonym: HH0021

Alternate gene names: 32265520

Gene position: 22148-23623 (Clockwise)

Preceding gene: 32265519

Following gene: 32265521

Centisome position: 1.23

GC content: 31.98

Gene sequence:

>1476_bases
ATGAAAAATACCATTACCCACCTTATTGATAAAATTTCCTTCCAAGCACAAACAACCATTTTAGTATGGATTATTGTCAT
CGGATTTACACTTATAGCAAGTGTGGGCTTACTTGCTCTTATGGGGATAAAGAGTGAATTTGACATTAACTCATCACAAA
GTCATAATATGTATACACTCACCTTATTAAATAAAGCATATGATATACACAAAAACGACCAGATACTCCTGCAACTCCTT
GAAATATGGGAACAATATAAAACTTATAATCTCCCAAAAGATCAAAATTCTACTATTAGTCATTTGCGCGAGTGGTATGC
TAAGACTTTTAAAATGCACTATTATCAACAGATTCAAAGATTACTTTCTAAAGAAAATGCTCTTATAGAATCTATTGATA
AAGCTTTTATTAATGATGGAGAGGATATTTCCTCGCTACTTGAAGAACAATTTCTCATTTCTTTTGATATTGCTTTTTAT
GGCAAAAAAATCACGGATTCTCTTTATAAAAATACCTTTATTGTCCTCGCAATCTTTATGCTTATTATCATCGCAACAAT
CATTATTCTTGCCTTTTCTATCAGACAATCTATCAATACCAATCATTTACTTTTAGAGCAACTCGTGCAATCAAAAACCA
AAGAACTCCAATCTCTTAATGTCAATCTGCAAAAATCAATAGAATATGAAGTTGAGCAAAATCGTAAAAAAGACTTGATT
ATGTATCAACAAGCTAGGCTTGCTTCTATGGGAGAAATGATACAAAATATTGCCCATCAATGGCGCCAACCACTTAATTC
TCTTATGATACTTATCCAAAGCTTTAAAAGTAGAGCAATGCAAAAAAAACTTGATAATGAATTTATAAACCAACAAACAC
AATATGGTATGAAAATTGCCACAGAAATGTCAAATACGATTGAAAATTTTCGTAATTTCTTTCACCCAGAAACAAATAAA
GAATTTTTTGAGCTCTCACAAAGCATTCGGAATTCTATTGAGCTGCTTAAAGCTCAATTTCAAGAGAATCTTATTCGTAT
TGAAGTAGATGTAAGCCCACAAGCACAAGATTTAAATATGCTTGGTTACCAAAATTCCTTTACTCAAGTGATTTTAATTC
TCATCAATAACGCCATTGACGCACTCAAGCTCAAAAGTCAAAATGATAAATCGTTTGAGAATCCACTCATAGAAATTTCA
TTAGATAAGCTAGGATATAATATTATTCTTTGTGTGAAAGATAATGCGGGAGGCATTGATTTGGAAGATAAATCAAAAGT
TTTTGAACCATATTTCACCACTAAACATAAATCGGTTGGAACAGGCGTGGGACTTTATATGGCAAAACAAATCATTGAAC
GCCAACTCAATGGCACAATAAGCGTATCTAATACACAATGGGGTAAGCAGAACCAATATTTTGGAGCAGAATTTACCATT
CACATACCAATACAAAAGGATAATTATGAATCTTGA

Upstream 100 bases:

>100_bases
AAATTAGCTATGCGCTTAAAAAGAATAGAGAATATTTTGTTCAATATGATTTACTCTCACGTGCCCTTGCTGATGCCATA
GCAAATGCAAAAGAGCTTAT

Downstream 100 bases:

>100_bases
TGCACTAAGCAAACTCACTATTTTGTATGCCGAGGATGATACCGACACAGCCAATCTTACGAATATGGTGCTTGGAGATT
ATGTAGGACGCCTACTTATT

Product: two-component sensor histidine kinase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MKNTITHLIDKISFQAQTTILVWIIVIGFTLIASVGLLALMGIKSEFDINSSQSHNMYTLTLLNKAYDIHKNDQILLQLL
EIWEQYKTYNLPKDQNSTISHLREWYAKTFKMHYYQQIQRLLSKENALIESIDKAFINDGEDISSLLEEQFLISFDIAFY
GKKITDSLYKNTFIVLAIFMLIIIATIIILAFSIRQSINTNHLLLEQLVQSKTKELQSLNVNLQKSIEYEVEQNRKKDLI
MYQQARLASMGEMIQNIAHQWRQPLNSLMILIQSFKSRAMQKKLDNEFINQQTQYGMKIATEMSNTIENFRNFFHPETNK
EFFELSQSIRNSIELLKAQFQENLIRIEVDVSPQAQDLNMLGYQNSFTQVILILINNAIDALKLKSQNDKSFENPLIEIS
LDKLGYNIILCVKDNAGGIDLEDKSKVFEPYFTTKHKSVGTGVGLYMAKQIIERQLNGTISVSNTQWGKQNQYFGAEFTI
HIPIQKDNYES

Sequences:

>Translated_491_residues
MKNTITHLIDKISFQAQTTILVWIIVIGFTLIASVGLLALMGIKSEFDINSSQSHNMYTLTLLNKAYDIHKNDQILLQLL
EIWEQYKTYNLPKDQNSTISHLREWYAKTFKMHYYQQIQRLLSKENALIESIDKAFINDGEDISSLLEEQFLISFDIAFY
GKKITDSLYKNTFIVLAIFMLIIIATIIILAFSIRQSINTNHLLLEQLVQSKTKELQSLNVNLQKSIEYEVEQNRKKDLI
MYQQARLASMGEMIQNIAHQWRQPLNSLMILIQSFKSRAMQKKLDNEFINQQTQYGMKIATEMSNTIENFRNFFHPETNK
EFFELSQSIRNSIELLKAQFQENLIRIEVDVSPQAQDLNMLGYQNSFTQVILILINNAIDALKLKSQNDKSFENPLIEIS
LDKLGYNIILCVKDNAGGIDLEDKSKVFEPYFTTKHKSVGTGVGLYMAKQIIERQLNGTISVSNTQWGKQNQYFGAEFTI
HIPIQKDNYES
>Mature_491_residues
MKNTITHLIDKISFQAQTTILVWIIVIGFTLIASVGLLALMGIKSEFDINSSQSHNMYTLTLLNKAYDIHKNDQILLQLL
EIWEQYKTYNLPKDQNSTISHLREWYAKTFKMHYYQQIQRLLSKENALIESIDKAFINDGEDISSLLEEQFLISFDIAFY
GKKITDSLYKNTFIVLAIFMLIIIATIIILAFSIRQSINTNHLLLEQLVQSKTKELQSLNVNLQKSIEYEVEQNRKKDLI
MYQQARLASMGEMIQNIAHQWRQPLNSLMILIQSFKSRAMQKKLDNEFINQQTQYGMKIATEMSNTIENFRNFFHPETNK
EFFELSQSIRNSIELLKAQFQENLIRIEVDVSPQAQDLNMLGYQNSFTQVILILINNAIDALKLKSQNDKSFENPLIEIS
LDKLGYNIILCVKDNAGGIDLEDKSKVFEPYFTTKHKSVGTGVGLYMAKQIIERQLNGTISVSNTQWGKQNQYFGAEFTI
HIPIQKDNYES

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=27.8225806451613, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=252, Percent_Identity=25, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56868; Mature: 56868

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTITHLIDKISFQAQTTILVWIIVIGFTLIASVGLLALMGIKSEFDINSSQSHNMYTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
TLLNKAYDIHKNDQILLQLLEIWEQYKTYNLPKDQNSTISHLREWYAKTFKMHYYQQIQR
EEEHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLSKENALIESIDKAFINDGEDISSLLEEQFLISFDIAFYGKKITDSLYKNTFIVLAIFM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEHHHHHCHHHHHHHHHHHHHHHHHHH
LIIIATIIILAFSIRQSINTNHLLLEQLVQSKTKELQSLNVNLQKSIEYEVEQNRKKDLI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHH
MYQQARLASMGEMIQNIAHQWRQPLNSLMILIQSFKSRAMQKKLDNEFINQQTQYGMKIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEMSNTIENFRNFFHPETNKEFFELSQSIRNSIELLKAQFQENLIRIEVDVSPQAQDLNM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHCCHH
LGYQNSFTQVILILINNAIDALKLKSQNDKSFENPLIEISLDKLGYNIILCVKDNAGGID
HCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCC
LEDKSKVFEPYFTTKHKSVGTGVGLYMAKQIIERQLNGTISVSNTQWGKQNQYFGAEFTI
CCCCHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEE
HIPIQKDNYES
EEEEECCCCCC
>Mature Secondary Structure
MKNTITHLIDKISFQAQTTILVWIIVIGFTLIASVGLLALMGIKSEFDINSSQSHNMYTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
TLLNKAYDIHKNDQILLQLLEIWEQYKTYNLPKDQNSTISHLREWYAKTFKMHYYQQIQR
EEEHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLSKENALIESIDKAFINDGEDISSLLEEQFLISFDIAFYGKKITDSLYKNTFIVLAIFM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEHHHHHCHHHHHHHHHHHHHHHHHHH
LIIIATIIILAFSIRQSINTNHLLLEQLVQSKTKELQSLNVNLQKSIEYEVEQNRKKDLI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHH
MYQQARLASMGEMIQNIAHQWRQPLNSLMILIQSFKSRAMQKKLDNEFINQQTQYGMKIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEMSNTIENFRNFFHPETNKEFFELSQSIRNSIELLKAQFQENLIRIEVDVSPQAQDLNM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHCCHH
LGYQNSFTQVILILINNAIDALKLKSQNDKSFENPLIEISLDKLGYNIILCVKDNAGGID
HCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCC
LEDKSKVFEPYFTTKHKSVGTGVGLYMAKQIIERQLNGTISVSNTQWGKQNQYFGAEFTI
CCCCHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEE
HIPIQKDNYES
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]