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The map label for this gene is pcm-1 [H]

Identifier: 308535315

GI number: 308535315

Start: 3107902

End: 3108549

Strand: Reverse

Name: pcm-1 [H]

Synonym: NA

Alternate gene names: 308535315

Gene position: 3108549-3107902 (Counterclockwise)

Preceding gene: 197119060

Following gene: 197119058

Centisome position: 67.36

GC content: 62.35

Gene sequence:

>648_bases
ATGAATTCTGCTGTTGCACGGAAGAGAATGGTTGCTGAGCTGGTGAAGCGTGGCATCACCGACCAGCGGGTGCTGGGCGC
CATGCAGGAAATACCGAGACACATATTCGTAGAAGAGGCCATGTCGGCCCAGGCCTACAGCGACGGATCGCTGCCGATAG
GCGAAAAGCAGACCATCTCGCAGCCGTACATTGTGGCGAAGATGACGCAGCTTCTGGCGCTCACCGGGCGCGAAAAGGTG
CTGGAGCTGGGAACCGGCTCAGGCTACCAGGCAGCCGTCCTCGCCACCCTCGCCGACCGGGTCTGCACCGTAGAGCGCAT
CAGGCCGCTGGCCCTCAAGGCGCGCAAGGCTCTCGACAGCCTCAGGCTTTTGAACGTGAACCTGAAGATAGGGGACGGAA
CCGAGGGGTGGGCCGAGGAGGCGCCTTTCGACGCCATCCTGGTTACCGCGGGCGCCCCGCATCTTCCCGACTGCCTGGTC
CAGCAGCTGGCCCCCGGGGGCAGGCTGGTGATACCGGTGGGCGACAGGATCGACCAGAAGCTCTTGCTGGTAACAAAGGG
AATGGACGGCAGTGTGGCCACCGAAGAGTGCGACGGCTGCCGCTTCGTAAGACTTATTGGAAGAAACGGCTGGAATGACG
AGCAGTAG

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase 2; Protein L-isoaspartyl methyltransferase 2; Protein-beta-aspartate methyltransferase 2; PIMT 2 [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:
NA

Sequences:

>Translated_215_residues
MNSAVARKRMVAELVKRGITDQRVLGAMQEIPRHIFVEEAMSAQAYSDGSLPIGEKQTISQPYIVAKMTQLLALTGREKV
LELGTGSGYQAAVLATLADRVCTVERIRPLALKARKALDSLRLLNVNLKIGDGTEGWAEEAPFDAILVTAGAPHLPDCLV
QQLAPGGRLVIPVGDRIDQKLLLVTKGMDGSVATEECDGCRFVRLIGRNGWNDEQ
>Mature_215_residues
MNSAVARKRMVAELVKRGITDQRVLGAMQEIPRHIFVEEAMSAQAYSDGSLPIGEKQTISQPYIVAKMTQLLALTGREKV
LELGTGSGYQAAVLATLADRVCTVERIRPLALKARKALDSLRLLNVNLKIGDGTEGWAEEAPFDAILVTAGAPHLPDCLV
QQLAPGGRLVIPVGDRIDQKLLLVTKGMDGSVATEECDGCRFVRLIGRNGWNDEQ

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=215, Percent_Identity=33.4883720930233, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI1789100, Length=197, Percent_Identity=47.2081218274112, Blast_Score=183, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71983477, Length=208, Percent_Identity=30.2884615384615, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193207222, Length=207, Percent_Identity=29.4685990338164, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17981723, Length=216, Percent_Identity=32.8703703703704, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 23288; Mature: 23288

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAVARKRMVAELVKRGITDQRVLGAMQEIPRHIFVEEAMSAQAYSDGSLPIGEKQTIS
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
QPYIVAKMTQLLALTGREKVLELGTGSGYQAAVLATLADRVCTVERIRPLALKARKALDS
CCHHHHHHHHHHHHCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRLLNVNLKIGDGTEGWAEEAPFDAILVTAGAPHLPDCLVQQLAPGGRLVIPVGDRIDQK
EEEEEEEEEECCCCCCCHHCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCE
LLLVTKGMDGSVATEECDGCRFVRLIGRNGWNDEQ
EEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MNSAVARKRMVAELVKRGITDQRVLGAMQEIPRHIFVEEAMSAQAYSDGSLPIGEKQTIS
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
QPYIVAKMTQLLALTGREKVLELGTGSGYQAAVLATLADRVCTVERIRPLALKARKALDS
CCHHHHHHHHHHHHCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRLLNVNLKIGDGTEGWAEEAPFDAILVTAGAPHLPDCLVQQLAPGGRLVIPVGDRIDQK
EEEEEEEEEECCCCCCCHHCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCE
LLLVTKGMDGSVATEECDGCRFVRLIGRNGWNDEQ
EEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA