Click here to switch to the map view.

The map label for this gene is phoR [H]

Identifier: 308535231

GI number: 308535231

Start: 1548106

End: 1549098

Strand: Reverse

Name: phoR [H]

Synonym: NA

Alternate gene names: 308535231

Gene position: 1549098-1548106 (Counterclockwise)

Preceding gene: 197117736

Following gene: 197117730

Centisome position: 33.57

GC content: 59.11

Gene sequence:

>993_bases
TTGCAAAAACGGATCTGCGATGCTACAGGTGGGTGCATGAAATCGCAAAGAAAACTCTCCAACCCGTTGATTGCACTGAT
AGGAATCCAGTTGATCTGGGTGGTCATGGTCATCTCCTGGGTCTACTGGTTCGTGGGCCGCAACAAGGAATTCCGCCAGT
TGGCGCTGCGCTACAAGCCGGAGCTCGTGGCCCAAGGGGTGGAGTGGCTGGTACTGGTCGAGGGACTTTTGATGCTGGTC
GCCGTCCTGGTCGGCGTCTACGTCATCTTCCTGTACTGGCGTCGCCAGGCGAAGCTCTACCTGCAGCAGCGCAATTACAT
CTCGCAACTCACCCACGAGCTCAAGTCACCGCTGACCTCGATCCAGCTCCACCTGGAGACGGTGAAGCTCAGGAATCTCC
CCAAGGACAAGCTGGACGGGTTCATCGACACCATGCTCTCGGACACGGACCGGCTCAACGTGCTCACCAGCAACCTGCTG
ATGGCAACGAGGATCGAGTTCCGCCAGCTGGGAGAAAAGGCCAAGAAGATCGACTTCTCCGAGTTCGTCACTGAGTACCT
GGAAGGGAAACGGGCGGAGTTGCCGGAGGGAGGGCGCCTCACACTCGAGGTCGAGAAAGGGATCTCGGCGGTCATCGACG
TCGAAGGGATGGAGATGGCGCTTCGCAACCTTTTGGAAAACGCCCTGCTCTACTCGCCGGTATCCCCGGAAATCCGGGTT
TCGCTGCGAAAAAGCGGCAAGCAGTGCCTGCTCGACTTCCAGGACAACGGCAAAGGGCTAAAGAAGAACGAGCTGAACAA
GATCTTCGAGATGTTCTACCGGGTGCGCACCCCCGGCGAAAACATCCGCGGGACCGGCCTTGGCCTCTATATCGTGAAGT
CGGTGGTTAATGCCCACGGCGGCAGGATCACCGTCAGCAGCGAGGGGCTCGGCAAGGGGTGCACCTTCCACATCGCGCTG
CCGCTACCCGGCGGCCAGCAGCAACGAGGTTAG

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:
NA

Sequences:

>Translated_330_residues
MQKRICDATGGCMKSQRKLSNPLIALIGIQLIWVVMVISWVYWFVGRNKEFRQLALRYKPELVAQGVEWLVLVEGLLMLV
AVLVGVYVIFLYWRRQAKLYLQQRNYISQLTHELKSPLTSIQLHLETVKLRNLPKDKLDGFIDTMLSDTDRLNVLTSNLL
MATRIEFRQLGEKAKKIDFSEFVTEYLEGKRAELPEGGRLTLEVEKGISAVIDVEGMEMALRNLLENALLYSPVSPEIRV
SLRKSGKQCLLDFQDNGKGLKKNELNKIFEMFYRVRTPGENIRGTGLGLYIVKSVVNAHGGRITVSSEGLGKGCTFHIAL
PLPGGQQQRG
>Mature_330_residues
MQKRICDATGGCMKSQRKLSNPLIALIGIQLIWVVMVISWVYWFVGRNKEFRQLALRYKPELVAQGVEWLVLVEGLLMLV
AVLVGVYVIFLYWRRQAKLYLQQRNYISQLTHELKSPLTSIQLHLETVKLRNLPKDKLDGFIDTMLSDTDRLNVLTSNLL
MATRIEFRQLGEKAKKIDFSEFVTEYLEGKRAELPEGGRLTLEVEKGISAVIDVEGMEMALRNLLENALLYSPVSPEIRV
SLRKSGKQCLLDFQDNGKGLKKNELNKIFEMFYRVRTPGENIRGTGLGLYIVKSVVNAHGGRITVSSEGLGKGCTFHIAL
PLPGGQQQRG

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=28.5067873303167, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790861, Length=214, Percent_Identity=31.3084112149533, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=277, Percent_Identity=24.9097472924188, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=27.1739130434783, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI48994928, Length=227, Percent_Identity=27.7533039647577, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=31.1965811965812, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=26.1061946902655, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=28.3898305084746, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=29.2035398230088, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=272, Percent_Identity=25.7352941176471, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=263, Percent_Identity=27.3764258555133, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789403, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37382; Mature: 37382

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKRICDATGGCMKSQRKLSNPLIALIGIQLIWVVMVISWVYWFVGRNKEFRQLALRYKP
CCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCH
ELVAQGVEWLVLVEGLLMLVAVLVGVYVIFLYWRRQAKLYLQQRNYISQLTHELKSPLTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IQLHLETVKLRNLPKDKLDGFIDTMLSDTDRLNVLTSNLLMATRIEFRQLGEKAKKIDFS
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EFVTEYLEGKRAELPEGGRLTLEVEKGISAVIDVEGMEMALRNLLENALLYSPVSPEIRV
HHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHH
SLRKSGKQCLLDFQDNGKGLKKNELNKIFEMFYRVRTPGENIRGTGLGLYIVKSVVNAHG
HHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
GRITVSSEGLGKGCTFHIALPLPGGQQQRG
CEEEEECCCCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MQKRICDATGGCMKSQRKLSNPLIALIGIQLIWVVMVISWVYWFVGRNKEFRQLALRYKP
CCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCH
ELVAQGVEWLVLVEGLLMLVAVLVGVYVIFLYWRRQAKLYLQQRNYISQLTHELKSPLTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IQLHLETVKLRNLPKDKLDGFIDTMLSDTDRLNVLTSNLLMATRIEFRQLGEKAKKIDFS
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EFVTEYLEGKRAELPEGGRLTLEVEKGISAVIDVEGMEMALRNLLENALLYSPVSPEIRV
HHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHH
SLRKSGKQCLLDFQDNGKGLKKNELNKIFEMFYRVRTPGENIRGTGLGLYIVKSVVNAHG
HHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
GRITVSSEGLGKGCTFHIALPLPGGQQQRG
CEEEEECCCCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]