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The map label for this gene is parC [H]

Identifier: 29348988

GI number: 29348988

Start: 4631899

End: 4634451

Strand: Reverse

Name: parC [H]

Synonym: BT_3579

Alternate gene names: 29348988

Gene position: 4634451-4631899 (Counterclockwise)

Preceding gene: 29348989

Following gene: 29348987

Centisome position: 74.03

GC content: 49.35

Gene sequence:

>2553_bases
ATGTACCAGAATTGGTTTCTGGACTATGCTTCTTATGTGATTCTGGAACGTGCCGTTCCCCATATCAATGACGGTTTGAA
GCCTGTACAACGACGTATTCTACATTCCATGAAGCGTCTGGACGACGGGCGGTATAACAAAGTGGCAAATATTGTGGGAC
ACACCATGCAGTTCCATCCGCACGGTGATGCTTCTATCGGCGATGCACTGGTACAGCTGGGGCAGAAAGACCTGCTGATA
GACTGTCAGGGTAACTGGGGTAATATACTCACCGGTGACGGTGCGGCAGCTCCCCGTTATATCGAGGCACGCCTTTCCAA
GTTTGCGCTGGACATCGTATTCAATCCAAAGACGACCGAATGGAAGCTGTCTTACGACGGCAGAAACAAGGAACCGGTCA
CCCTCCCCGTGAAGTTCCCGCTATTGCTGGCACAGGGAGTGGAAGGTATCGCCGTCGGACTTTCATCCAAGATATTACCT
CACAACTTCAATGAACTTTGCGACGCCTCCATCAGCTATCTGCATGGAGAATCGTTCCAGCTATATCCCGACTTCCAGAC
AGGCGGTTCCATCGACGTAGCCAAATACAATGACGGAGAACGCGGCGGAGCGGTAAAAGTACGCGCCAAGATCAACAAGC
TGGACAACAAGACACTCGCCATCACGGAGATTCCGTATGGCAAGACCACCTCTACCGTCATCGACTCCATCCTGAAAGCT
GTTGACAAAGGAAAAATCAAGATACGCAAAGTAGACGATAATACAGCCGCCAACGTAGAGATACTGGTACACCTGGCACC
CGGAACTTCATCGGACAAAACGATCGACGCACTGTACGCCTTTACCGACTGCGAGGTAAGCATCTCACCCAACTGCTGTG
TGATTGATGACAGCAAGCCTCACTTCCTCACCGTCAGCAAGGTACTGAAAAAGTCGGCAGACAACACACTGGGACTGCTG
AAACAGGAACTGGAAATCAAGAAAGGGGAAATACTGGAATCACTCCATTTCGCTTCCCTCGAAAAAATATTTATCGAAGA
ACGAATCTATAAGGACAAAGAGTTCGAGCAATCCAAAGACATGGACGCCGCCTGCGCACATATCGACGACCGCCTGACTC
CTTTCTACCCGAGCTTTATCCGTGAAGTGACCAAAGAGGATATTCTCAAACTGATGGAAATCAAGATGGGGCGCATCCTG
AAGTTCAACACCGACAAAGCCGATGAACTGATCGCCCGTATGAAAGAAGAGATCGCCGAAATCGACGATCACCTCGCTCA
CATCGTGGACTATACCGTAAACTGGTATCAGATGCTGAAAAGCAAATACGGAAAGAACTTCCCGCGCCGCACCGAACTGC
GCAACTTCGACACCATCGAAGCCGCCAAAGTGGTAGAGGCCAACGAGAAACTCTACATCAACCGTGATGAAGGATTTATC
GGAACAGCACTGAAGAAGGATGAATTCGTAGCCAACTGTTCGGATATCGATGACGTGATCGTCTTCTTCCGGGATGGTAA
ATATATCGTCACTCCGGTAGCCGACAAGAAGTTTGTGGGCAAAAACATTCTTTACGTCAATGTATTCAAGAAGAATGACA
AACGCACCATCTACAATATCACTTACCGGGACGGCAAAGAAGGAACGACGTATATCAAACGTTTTGCCGTGACAGGTGTG
GTCCGCGACCGTGAATACGATGTCACGCAAGGAACGCCGGACTCACGCATCACTTATTTCAGCGCCAACCCGAACGGAGA
AGCCGAAATCATCAAAGTGACATTAAAGCCGAACCCGCGTGTAAGACGCATCATCTTCGAACGTGATTTCAGTGAAATCA
GCATCAAGGGACGTCAGGCACAGGGAGTGATCCTCACCCGACTGCCGGTGCATAAGATTACCCTGAAACAGAAAGGAGGC
TCTACCCTCGGAGGACGAAAAGTCTGGTTCGACCGCGATATCCTGCGCCTCAACTACGACGGACGGGGTGAATATCTGGG
AGAATTCCAAAGCGACGACACCATTCTGGTAGTGCTCAACAATGGCGAGTTCTACACCACTAATTTCGATTTGAGCAACC
ACTACGAAGATAATGTCAGCATCGTCGAGAAGTTCGACCCGAACAAGATATGGACTGCCGCGCTTTATGATGCCGACCAG
CAGAACTATCCGTATCTGAAACGTTTCTGTTTTGAAGGTTCCAACCGCAAGCAGAACTATCTGGGAGACAACAAGAATAC
CCGTCTGATCCTGCTGACTGATGAGTACTATCCTCGTCTGGAAGTCATATTCGGCGGACACGATAGTTTCCGTGAAGCGA
TGGTAATTGACGCGGAAGAATTTATTGCAGTCAAAGGCTTCAAGGCAAAAGGAAAGCGTATCACTACTTATACGGTGGAT
ACCATCAACGAACTTGAACCGACCCGTTTCCCGGAACCGACTAACGAACAACCGGAACAACCGGAAGAAGAACCGGAAAA
TCTGGACCCGGACAGCGATAAGAGCGAAGGGGACATCATCGATGAGATTACGGGACAGATGAAGCTGTTTTAG

Upstream 100 bases:

>100_bases
TTGATATATGAGTGACGAAATCAACGAGATAACGGAAGGACATTCAGACTACAAACCGGCGGACGCGCGGGACGAAAACG
TAAAGCATCAGTTAACAGGC

Downstream 100 bases:

>100_bases
CTAATGTATACATGCGGTAAAAAATACCCAATGTGCCAATGAAGAAAAACTTATTATACTTAGGGCTGACAGGATACCTC
CTGTTCGCCCTCTGCACAAG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 850; Mature: 850

Protein sequence:

>850_residues
MYQNWFLDYASYVILERAVPHINDGLKPVQRRILHSMKRLDDGRYNKVANIVGHTMQFHPHGDASIGDALVQLGQKDLLI
DCQGNWGNILTGDGAAAPRYIEARLSKFALDIVFNPKTTEWKLSYDGRNKEPVTLPVKFPLLLAQGVEGIAVGLSSKILP
HNFNELCDASISYLHGESFQLYPDFQTGGSIDVAKYNDGERGGAVKVRAKINKLDNKTLAITEIPYGKTTSTVIDSILKA
VDKGKIKIRKVDDNTAANVEILVHLAPGTSSDKTIDALYAFTDCEVSISPNCCVIDDSKPHFLTVSKVLKKSADNTLGLL
KQELEIKKGEILESLHFASLEKIFIEERIYKDKEFEQSKDMDAACAHIDDRLTPFYPSFIREVTKEDILKLMEIKMGRIL
KFNTDKADELIARMKEEIAEIDDHLAHIVDYTVNWYQMLKSKYGKNFPRRTELRNFDTIEAAKVVEANEKLYINRDEGFI
GTALKKDEFVANCSDIDDVIVFFRDGKYIVTPVADKKFVGKNILYVNVFKKNDKRTIYNITYRDGKEGTTYIKRFAVTGV
VRDREYDVTQGTPDSRITYFSANPNGEAEIIKVTLKPNPRVRRIIFERDFSEISIKGRQAQGVILTRLPVHKITLKQKGG
STLGGRKVWFDRDILRLNYDGRGEYLGEFQSDDTILVVLNNGEFYTTNFDLSNHYEDNVSIVEKFDPNKIWTAALYDADQ
QNYPYLKRFCFEGSNRKQNYLGDNKNTRLILLTDEYYPRLEVIFGGHDSFREAMVIDAEEFIAVKGFKAKGKRITTYTVD
TINELEPTRFPEPTNEQPEQPEEEPENLDPDSDKSEGDIIDEITGQMKLF

Sequences:

>Translated_850_residues
MYQNWFLDYASYVILERAVPHINDGLKPVQRRILHSMKRLDDGRYNKVANIVGHTMQFHPHGDASIGDALVQLGQKDLLI
DCQGNWGNILTGDGAAAPRYIEARLSKFALDIVFNPKTTEWKLSYDGRNKEPVTLPVKFPLLLAQGVEGIAVGLSSKILP
HNFNELCDASISYLHGESFQLYPDFQTGGSIDVAKYNDGERGGAVKVRAKINKLDNKTLAITEIPYGKTTSTVIDSILKA
VDKGKIKIRKVDDNTAANVEILVHLAPGTSSDKTIDALYAFTDCEVSISPNCCVIDDSKPHFLTVSKVLKKSADNTLGLL
KQELEIKKGEILESLHFASLEKIFIEERIYKDKEFEQSKDMDAACAHIDDRLTPFYPSFIREVTKEDILKLMEIKMGRIL
KFNTDKADELIARMKEEIAEIDDHLAHIVDYTVNWYQMLKSKYGKNFPRRTELRNFDTIEAAKVVEANEKLYINRDEGFI
GTALKKDEFVANCSDIDDVIVFFRDGKYIVTPVADKKFVGKNILYVNVFKKNDKRTIYNITYRDGKEGTTYIKRFAVTGV
VRDREYDVTQGTPDSRITYFSANPNGEAEIIKVTLKPNPRVRRIIFERDFSEISIKGRQAQGVILTRLPVHKITLKQKGG
STLGGRKVWFDRDILRLNYDGRGEYLGEFQSDDTILVVLNNGEFYTTNFDLSNHYEDNVSIVEKFDPNKIWTAALYDADQ
QNYPYLKRFCFEGSNRKQNYLGDNKNTRLILLTDEYYPRLEVIFGGHDSFREAMVIDAEEFIAVKGFKAKGKRITTYTVD
TINELEPTRFPEPTNEQPEQPEEEPENLDPDSDKSEGDIIDEITGQMKLF
>Mature_850_residues
MYQNWFLDYASYVILERAVPHINDGLKPVQRRILHSMKRLDDGRYNKVANIVGHTMQFHPHGDASIGDALVQLGQKDLLI
DCQGNWGNILTGDGAAAPRYIEARLSKFALDIVFNPKTTEWKLSYDGRNKEPVTLPVKFPLLLAQGVEGIAVGLSSKILP
HNFNELCDASISYLHGESFQLYPDFQTGGSIDVAKYNDGERGGAVKVRAKINKLDNKTLAITEIPYGKTTSTVIDSILKA
VDKGKIKIRKVDDNTAANVEILVHLAPGTSSDKTIDALYAFTDCEVSISPNCCVIDDSKPHFLTVSKVLKKSADNTLGLL
KQELEIKKGEILESLHFASLEKIFIEERIYKDKEFEQSKDMDAACAHIDDRLTPFYPSFIREVTKEDILKLMEIKMGRIL
KFNTDKADELIARMKEEIAEIDDHLAHIVDYTVNWYQMLKSKYGKNFPRRTELRNFDTIEAAKVVEANEKLYINRDEGFI
GTALKKDEFVANCSDIDDVIVFFRDGKYIVTPVADKKFVGKNILYVNVFKKNDKRTIYNITYRDGKEGTTYIKRFAVTGV
VRDREYDVTQGTPDSRITYFSANPNGEAEIIKVTLKPNPRVRRIIFERDFSEISIKGRQAQGVILTRLPVHKITLKQKGG
STLGGRKVWFDRDILRLNYDGRGEYLGEFQSDDTILVVLNNGEFYTTNFDLSNHYEDNVSIVEKFDPNKIWTAALYDADQ
QNYPYLKRFCFEGSNRKQNYLGDNKNTRLILLTDEYYPRLEVIFGGHDSFREAMVIDAEEFIAVKGFKAKGKRITTYTVD
TINELEPTRFPEPTNEQPEQPEEEPENLDPDSDKSEGDIIDEITGQMKLF

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=300, Percent_Identity=27, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI19913408, Length=332, Percent_Identity=26.2048192771084, Blast_Score=79, Evalue=3e-14,
Organism=Escherichia coli, GI1788562, Length=335, Percent_Identity=31.044776119403, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1789396, Length=372, Percent_Identity=29.8387096774194, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17535065, Length=307, Percent_Identity=24.4299674267101, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=360, Percent_Identity=25.5555555555556, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=271, Percent_Identity=27.6752767527675, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136538, Length=273, Percent_Identity=27.1062271062271, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 96801; Mature: 96801

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQNWFLDYASYVILERAVPHINDGLKPVQRRILHSMKRLDDGRYNKVANIVGHTMQFHP
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECC
HGDASIGDALVQLGQKDLLIDCQGNWGNILTGDGAAAPRYIEARLSKFALDIVFNPKTTE
CCCCHHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCHHHHHHHHHEEEEEEECCCCCE
WKLSYDGRNKEPVTLPVKFPLLLAQGVEGIAVGLSSKILPHNFNELCDASISYLHGESFQ
EEEEECCCCCCCEEEEEEHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEE
LYPDFQTGGSIDVAKYNDGERGGAVKVRAKINKLDNKTLAITEIPYGKTTSTVIDSILKA
EEECCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHH
VDKGKIKIRKVDDNTAANVEILVHLAPGTSSDKTIDALYAFTDCEVSISPNCCVIDDSKP
HCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEEEEECCEEEECCCEEEEECCCC
HFLTVSKVLKKSADNTLGLLKQELEIKKGEILESLHFASLEKIFIEERIYKDKEFEQSKD
CEEEHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
MDAACAHIDDRLTPFYPSFIREVTKEDILKLMEIKMGRILKFNTDKADELIARMKEEIAE
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
IDDHLAHIVDYTVNWYQMLKSKYGKNFPRRTELRNFDTIEAAKVVEANEKLYINRDEGFI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHEECCCEEEEECCCCCE
GTALKKDEFVANCSDIDDVIVFFRDGKYIVTPVADKKFVGKNILYVNVFKKNDKRTIYNI
EEEECCCCCEECCCCCCEEEEEEECCCEEEEECCCCCCCCCEEEEEEEEECCCCEEEEEE
TYRDGKEGTTYIKRFAVTGVVRDREYDVTQGTPDSRITYFSANPNGEAEIIKVTLKPNPR
EECCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCC
VRRIIFERDFSEISIKGRQAQGVILTRLPVHKITLKQKGGSTLGGRKVWFDRDILRLNYD
EEEEEEECCCCEEEEECCCCCCEEEEECCCEEEEEECCCCCCCCCEEEEECCCEEEEECC
GRGEYLGEFQSDDTILVVLNNGEFYTTNFDLSNHYEDNVSIVEKFDPNKIWTAALYDADQ
CCCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCCCEEEEECCCCCEEEEEEECCCC
QNYPYLKRFCFEGSNRKQNYLGDNKNTRLILLTDEYYPRLEVIFGGHDSFREAMVIDAEE
CCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHHHEEEECHHH
FIAVKGFKAKGKRITTYTVDTINELEPTRFPEPTNEQPEQPEEEPENLDPDSDKSEGDII
HEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
DEITGQMKLF
HHCCCCEECC
>Mature Secondary Structure
MYQNWFLDYASYVILERAVPHINDGLKPVQRRILHSMKRLDDGRYNKVANIVGHTMQFHP
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECC
HGDASIGDALVQLGQKDLLIDCQGNWGNILTGDGAAAPRYIEARLSKFALDIVFNPKTTE
CCCCHHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCHHHHHHHHHEEEEEEECCCCCE
WKLSYDGRNKEPVTLPVKFPLLLAQGVEGIAVGLSSKILPHNFNELCDASISYLHGESFQ
EEEEECCCCCCCEEEEEEHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEE
LYPDFQTGGSIDVAKYNDGERGGAVKVRAKINKLDNKTLAITEIPYGKTTSTVIDSILKA
EEECCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHH
VDKGKIKIRKVDDNTAANVEILVHLAPGTSSDKTIDALYAFTDCEVSISPNCCVIDDSKP
HCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEEEEECCEEEECCCEEEEECCCC
HFLTVSKVLKKSADNTLGLLKQELEIKKGEILESLHFASLEKIFIEERIYKDKEFEQSKD
CEEEHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
MDAACAHIDDRLTPFYPSFIREVTKEDILKLMEIKMGRILKFNTDKADELIARMKEEIAE
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
IDDHLAHIVDYTVNWYQMLKSKYGKNFPRRTELRNFDTIEAAKVVEANEKLYINRDEGFI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHEECCCEEEEECCCCCE
GTALKKDEFVANCSDIDDVIVFFRDGKYIVTPVADKKFVGKNILYVNVFKKNDKRTIYNI
EEEECCCCCEECCCCCCEEEEEEECCCEEEEECCCCCCCCCEEEEEEEEECCCCEEEEEE
TYRDGKEGTTYIKRFAVTGVVRDREYDVTQGTPDSRITYFSANPNGEAEIIKVTLKPNPR
EECCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCC
VRRIIFERDFSEISIKGRQAQGVILTRLPVHKITLKQKGGSTLGGRKVWFDRDILRLNYD
EEEEEEECCCCEEEEECCCCCCEEEEECCCEEEEEECCCCCCCCCEEEEECCCEEEEECC
GRGEYLGEFQSDDTILVVLNNGEFYTTNFDLSNHYEDNVSIVEKFDPNKIWTAALYDADQ
CCCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCCCEEEEECCCCCEEEEEEECCCC
QNYPYLKRFCFEGSNRKQNYLGDNKNTRLILLTDEYYPRLEVIFGGHDSFREAMVIDAEE
CCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHHHEEEECHHH
FIAVKGFKAKGKRITTYTVDTINELEPTRFPEPTNEQPEQPEEEPENLDPDSDKSEGDII
HEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
DEITGQMKLF
HHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]