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The map label for this gene is apt

Identifier: 29348676

GI number: 29348676

Start: 4171236

End: 4171766

Strand: Reverse

Name: apt

Synonym: BT_3267

Alternate gene names: 29348676

Gene position: 4171766-4171236 (Counterclockwise)

Preceding gene: 29348677

Following gene: 29348675

Centisome position: 66.64

GC content: 43.69

Gene sequence:

>531_bases
ATGATTATGAGCAAAGAAACGCTAATTAAAAGCATCCGGGAAATTCCCGATTTTCCGATCCCCGGAATCCTTTTCTACGA
TGTCACCACCCTGTTTAAAGACCCTTGGTGCTTGCAAGAATTATCGAACATCATGTTCGAAATGTACAAGGATAAAGGTA
TCACCAAAGTAGTAGGTATAGAATCCAGAGGATTCATCATGGGGCCTATCCTAGCTACCCGACTGAACGCAGGTTTTATT
CCTATCCGCAAGCCGGGCAAACTTCCCGCAGAGGTGATCGAAGAAAGCTACGACAAAGAATATGGCACGGACACTGTGCA
GATTCATAAGGACGCACTCGATGAAAACGACGTAGTTTTACTACACGACGACCTGCTGGCAACGGGAGGAACTATGAAAG
CAGCCTGCGAACTGGTGAAGAAACTGAAGCCTAAAAAGGTATATGTAAACTTCATTATCGAATTGAAAGACCTGAATGGC
AAATCCGTATTCGGAGATGACGTAGAAGTAGAATCCGTATTGACTTTATAA

Upstream 100 bases:

>100_bases
GAGTATCACCAAGCGACATCAACGTATTGCTGGTACTTTCCGGCCGATAAGCGGCAACGTTTCACGTGAAACAAATCATT
TAAAGAAACGAGATAAACCA

Downstream 100 bases:

>100_bases
ACAAATTGCTTATATTTGCAGGGCGTAGAGAATCTACGCCCTTTTTTATTTCCCGCTATTTCATCTATAACGATTATGAA
TACAGAACCGGAAGCCAAAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MIMSKETLIKSIREIPDFPIPGILFYDVTTLFKDPWCLQELSNIMFEMYKDKGITKVVGIESRGFIMGPILATRLNAGFI
PIRKPGKLPAEVIEESYDKEYGTDTVQIHKDALDENDVVLLHDDLLATGGTMKAACELVKKLKPKKVYVNFIIELKDLNG
KSVFGDDVEVESVLTL

Sequences:

>Translated_176_residues
MIMSKETLIKSIREIPDFPIPGILFYDVTTLFKDPWCLQELSNIMFEMYKDKGITKVVGIESRGFIMGPILATRLNAGFI
PIRKPGKLPAEVIEESYDKEYGTDTVQIHKDALDENDVVLLHDDLLATGGTMKAACELVKKLKPKKVYVNFIIELKDLNG
KSVFGDDVEVESVLTL
>Mature_176_residues
MIMSKETLIKSIREIPDFPIPGILFYDVTTLFKDPWCLQELSNIMFEMYKDKGITKVVGIESRGFIMGPILATRLNAGFI
PIRKPGKLPAEVIEESYDKEYGTDTVQIHKDALDENDVVLLHDDLLATGGTMKAACELVKKLKPKKVYVNFIIELKDLNG
KSVFGDDVEVESVLTL

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=155, Percent_Identity=41.2903225806452, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI71773201, Length=123, Percent_Identity=41.4634146341463, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=51.5923566878981, Blast_Score=161, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17509087, Length=159, Percent_Identity=45.2830188679245, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=156, Percent_Identity=41.6666666666667, Blast_Score=118, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=155, Percent_Identity=32.9032258064516, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136334, Length=152, Percent_Identity=38.8157894736842, Blast_Score=104, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_BACTN (Q8A2N8)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_812179.1
- ProteinModelPortal:   Q8A2N8
- SMR:   Q8A2N8
- GeneID:   1075872
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_3267
- NMPDR:   fig|226186.1.peg.3266
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q8A2N8
- ProtClustDB:   PRK02304
- BioCyc:   BTHE226186:BT_3267-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19781; Mature: 19781

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMSKETLIKSIREIPDFPIPGILFYDVTTLFKDPWCLQELSNIMFEMYKDKGITKVVGI
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEE
ESRGFIMGPILATRLNAGFIPIRKPGKLPAEVIEESYDKEYGTDTVQIHKDALDENDVVL
CCCCEEEHHHHHHHHCCCEEECCCCCCCCHHHHHHHHCHHCCCCEEEEECCCCCCCCEEE
LHDDLLATGGTMKAACELVKKLKPKKVYVNFIIELKDLNGKSVFGDDVEVESVLTL
EECCHHHCCCCHHHHHHHHHHCCCCEEEEEEEEEEECCCCCEECCCCCCHHHEECC
>Mature Secondary Structure
MIMSKETLIKSIREIPDFPIPGILFYDVTTLFKDPWCLQELSNIMFEMYKDKGITKVVGI
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEE
ESRGFIMGPILATRLNAGFIPIRKPGKLPAEVIEESYDKEYGTDTVQIHKDALDENDVVL
CCCCEEEHHHHHHHHCCCEEECCCCCCCCHHHHHHHHCHHCCCCEEEEECCCCCCCCEEE
LHDDLLATGGTMKAACELVKKLKPKKVYVNFIIELKDLNGKSVFGDDVEVESVLTL
EECCHHHCCCCHHHHHHHHHHCCCCEEEEEEEEEEECCCCCEECCCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928