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The map label for this gene is uvrC

Identifier: 29348675

GI number: 29348675

Start: 4169331

End: 4171160

Strand: Reverse

Name: uvrC

Synonym: BT_3266

Alternate gene names: 29348675

Gene position: 4171160-4169331 (Counterclockwise)

Preceding gene: 29348676

Following gene: 29348674

Centisome position: 66.63

GC content: 43.93

Gene sequence:

>1830_bases
ATGAATACAGAACCGGAAGCCAAAACGAATGAATATCTGAGAGGTATTGTAGCCAACCTGCCCGAAAAGCCGGGAGTCTA
TCAGTATCTGAACACAGAAGGGACTATTATATACGTTGGAAAGGCTAAAAACCTAAAAAAAAGGGTATATTCTTACTTCA
GCAAAGAGCATGAACCCGGCAAGACACGAGTATTGGTCAGCAAGATTGCCGATATCCGTTACATCGTTGTTAACACCGAA
GAAGATGCATTATTGCTGGAAAACAATCTGATCAAGAAATATAAGCCCCGCTACAATGTATTGCTGAAGGACGACAAGAC
CTACCCTTCCATCTGCGTGCAGAATGAATACTTTCCACGCATTTTCAGGACTCGAAAGATTATCAAAAACGGTTCTTCTT
ATTATGGTCCCTACAGCCACCTTCCTTCGATGTATGCGGTGCTCGACCTGATCAAGCATCTATACCCGTTGCGTACCTGC
AATCTGAACCTTTCTCCGGAGAACATACGGGCGGGAAAGTTCAAGGTTTGTCTGGAGTATCACATCAAGAAGTGCGCCGG
ACCATGCGTTGGACTGCAATCGCACGAGGATTATCTGAAGAACATCGATGAAATCAAAGAGATTTTGAAAGGAAATACGC
AGGATATTAGCCGTATGCTGGTAGAAAAGATGCAGGAACTGGCCAATGAAATGAAGTTTGAAGAGGCTCAGAAGATTAAG
GAGAAGTATCTGCTGATAGAGAATTACCGGTCTAAATCGGAGGTAGTAAGTTCTGTCCTGCACAATATCGACGTCTTTTC
CATCGAAGAAGACGATTCAAATTCGGCTTTCGTCAACTATCTGCACATCACCAATGGCGCCATCAATCAGGCATTCACCT
TTGAGTACAAGAAGAAGCTAAATGAATCGAAAGAAGAGTTACTGACGCTAGGCATTATTGAAATGCGGGAGCGCTACAAG
AGCCATTCACGGGAGATTATTGTTCCTTTCGAACTTGATCTGGAGTTGAATAATGTCGTTTTCACCGTTCCTCAAAGGGG
AGATAAGAAAAAACTGCTCGATCTTTCTATCCTAAATGTGAAGCAATATAAGGCCGACCGATTGAAACAAGCCGAGAAAC
TGAACCCGGAGCAGCGCAGTATGCGTCTGCTGAAAGAAATACAAAACGAACTGCATTTAGACAAGCCACCTTTGCAGATT
GAATGTTTCGATAACTCGAATATACAAGGATCGGATGCCGTAGCTGCCTGCGTAGTATTCAAAAAGGCGAAACCATCGAA
GAAAGATTACCGTAAATACAATATTAAGACGGTCGTGGGACCGGATGATTACGCTTCCATGAAAGAGGTGGTCAGACGAC
GTTATCAGCGCGCCATTGAAGAAAATTCTCCCCTTCCCGACCTGATTATTACCGATGGTGGTAAAGGACAAATGGAAGTC
GTCAGAGAAGTAATCGAGGATGAACTGCATCTGAATATTCCGATTGCCGGTTTGGCTAAGGATAATAAGCATCGCACGTC
AGAGCTACTTTTCGGGTTTCCCGCACAGACGATTGGGATCAAACAACAAAGTTCTTTATTCCGTCTGCTGACGCAGATTC
AGGATGAAGTACACCGTTTTGCGATTACTTTCCACCGCGACAAGCGCAGCAAGCGACAGGTCGCATCGGCTCTGGATAGC
ATTAAAGGGATTGGAGAAAAGACAAAAACAGCCCTATTGAAGGAGTTTAAAAGCGTAAAACGAATCAAAGAGGCATCCCT
TGAAGAAATCGCAAAGGTCATAGGAGAAGTGAAGGCTCAGACTGTAAAAAAAGGGTTAAGCAACGAATAG

Upstream 100 bases:

>100_bases
AGTAGAATCCGTATTGACTTTATAAACAAATTGCTTATATTTGCAGGGCGTAGAGAATCTACGCCCTTTTTTATTTCCCG
CTATTTCATCTATAACGATT

Downstream 100 bases:

>100_bases
GCTCACTTCTATGTGGCTATACGCTAAATTGTTAGTCCATATAAATCAAGTATCAGTATCATATGGGGCAAGCGTTAGTT
TCCTCGGAGGAAACGCCAGT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MNTEPEAKTNEYLRGIVANLPEKPGVYQYLNTEGTIIYVGKAKNLKKRVYSYFSKEHEPGKTRVLVSKIADIRYIVVNTE
EDALLLENNLIKKYKPRYNVLLKDDKTYPSICVQNEYFPRIFRTRKIIKNGSSYYGPYSHLPSMYAVLDLIKHLYPLRTC
NLNLSPENIRAGKFKVCLEYHIKKCAGPCVGLQSHEDYLKNIDEIKEILKGNTQDISRMLVEKMQELANEMKFEEAQKIK
EKYLLIENYRSKSEVVSSVLHNIDVFSIEEDDSNSAFVNYLHITNGAINQAFTFEYKKKLNESKEELLTLGIIEMRERYK
SHSREIIVPFELDLELNNVVFTVPQRGDKKKLLDLSILNVKQYKADRLKQAEKLNPEQRSMRLLKEIQNELHLDKPPLQI
ECFDNSNIQGSDAVAACVVFKKAKPSKKDYRKYNIKTVVGPDDYASMKEVVRRRYQRAIEENSPLPDLIITDGGKGQMEV
VREVIEDELHLNIPIAGLAKDNKHRTSELLFGFPAQTIGIKQQSSLFRLLTQIQDEVHRFAITFHRDKRSKRQVASALDS
IKGIGEKTKTALLKEFKSVKRIKEASLEEIAKVIGEVKAQTVKKGLSNE

Sequences:

>Translated_609_residues
MNTEPEAKTNEYLRGIVANLPEKPGVYQYLNTEGTIIYVGKAKNLKKRVYSYFSKEHEPGKTRVLVSKIADIRYIVVNTE
EDALLLENNLIKKYKPRYNVLLKDDKTYPSICVQNEYFPRIFRTRKIIKNGSSYYGPYSHLPSMYAVLDLIKHLYPLRTC
NLNLSPENIRAGKFKVCLEYHIKKCAGPCVGLQSHEDYLKNIDEIKEILKGNTQDISRMLVEKMQELANEMKFEEAQKIK
EKYLLIENYRSKSEVVSSVLHNIDVFSIEEDDSNSAFVNYLHITNGAINQAFTFEYKKKLNESKEELLTLGIIEMRERYK
SHSREIIVPFELDLELNNVVFTVPQRGDKKKLLDLSILNVKQYKADRLKQAEKLNPEQRSMRLLKEIQNELHLDKPPLQI
ECFDNSNIQGSDAVAACVVFKKAKPSKKDYRKYNIKTVVGPDDYASMKEVVRRRYQRAIEENSPLPDLIITDGGKGQMEV
VREVIEDELHLNIPIAGLAKDNKHRTSELLFGFPAQTIGIKQQSSLFRLLTQIQDEVHRFAITFHRDKRSKRQVASALDS
IKGIGEKTKTALLKEFKSVKRIKEASLEEIAKVIGEVKAQTVKKGLSNE
>Mature_609_residues
MNTEPEAKTNEYLRGIVANLPEKPGVYQYLNTEGTIIYVGKAKNLKKRVYSYFSKEHEPGKTRVLVSKIADIRYIVVNTE
EDALLLENNLIKKYKPRYNVLLKDDKTYPSICVQNEYFPRIFRTRKIIKNGSSYYGPYSHLPSMYAVLDLIKHLYPLRTC
NLNLSPENIRAGKFKVCLEYHIKKCAGPCVGLQSHEDYLKNIDEIKEILKGNTQDISRMLVEKMQELANEMKFEEAQKIK
EKYLLIENYRSKSEVVSSVLHNIDVFSIEEDDSNSAFVNYLHITNGAINQAFTFEYKKKLNESKEELLTLGIIEMRERYK
SHSREIIVPFELDLELNNVVFTVPQRGDKKKLLDLSILNVKQYKADRLKQAEKLNPEQRSMRLLKEIQNELHLDKPPLQI
ECFDNSNIQGSDAVAACVVFKKAKPSKKDYRKYNIKTVVGPDDYASMKEVVRRRYQRAIEENSPLPDLIITDGGKGQMEV
VREVIEDELHLNIPIAGLAKDNKHRTSELLFGFPAQTIGIKQQSSLFRLLTQIQDEVHRFAITFHRDKRSKRQVASALDS
IKGIGEKTKTALLKEFKSVKRIKEASLEEIAKVIGEVKAQTVKKGLSNE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=607, Percent_Identity=33.2784184514003, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1788037, Length=205, Percent_Identity=26.3414634146341, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_BACTN (Q8A2N9)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_812178.1
- ProteinModelPortal:   Q8A2N9
- GeneID:   1075868
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_3266
- NMPDR:   fig|226186.1.peg.3265
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q8A2N9
- ProtClustDB:   PRK00558
- BioCyc:   BTHE226186:BT_3266-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70187; Mature: 70187

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTEPEAKTNEYLRGIVANLPEKPGVYQYLNTEGTIIYVGKAKNLKKRVYSYFSKEHEPG
CCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCC
KTRVLVSKIADIRYIVVNTEEDALLLENNLIKKYKPRYNVLLKDDKTYPSICVQNEYFPR
HHHHHHHHHCCEEEEEEECCCCCEEHHHHHHHHCCCCCCEEEECCCCCCCEEECCCHHHH
IFRTRKIIKNGSSYYGPYSHLPSMYAVLDLIKHLYPLRTCNLNLSPENIRAGKFKVCLEY
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCCCHHHHHHHH
HIKKCAGPCVGLQSHEDYLKNIDEIKEILKGNTQDISRMLVEKMQELANEMKFEEAQKIK
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKYLLIENYRSKSEVVSSVLHNIDVFSIEEDDSNSAFVNYLHITNGAINQAFTFEYKKKL
HHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHC
NESKEELLTLGIIEMRERYKSHSREIIVPFELDLELNNVVFTVPQRGDKKKLLDLSILNV
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECEEECCEEEECCCCCCCHHHHHHHHHHH
KQYKADRLKQAEKLNPEQRSMRLLKEIQNELHLDKPPLQIECFDNSNIQGSDAVAACVVF
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHH
KKAKPSKKDYRKYNIKTVVGPDDYASMKEVVRRRYQRAIEENSPLPDLIITDGGKGQMEV
HCCCCCHHHHHEECEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHH
VREVIEDELHLNIPIAGLAKDNKHRTSELLFGFPAQTIGIKQQSSLFRLLTQIQDEVHRF
HHHHHHCCCEECCCEEECCCCCCHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHH
AITFHRDKRSKRQVASALDSIKGIGEKTKTALLKEFKSVKRIKEASLEEIAKVIGEVKAQ
HHEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVKKGLSNE
HHHHCCCCC
>Mature Secondary Structure
MNTEPEAKTNEYLRGIVANLPEKPGVYQYLNTEGTIIYVGKAKNLKKRVYSYFSKEHEPG
CCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCC
KTRVLVSKIADIRYIVVNTEEDALLLENNLIKKYKPRYNVLLKDDKTYPSICVQNEYFPR
HHHHHHHHHCCEEEEEEECCCCCEEHHHHHHHHCCCCCCEEEECCCCCCCEEECCCHHHH
IFRTRKIIKNGSSYYGPYSHLPSMYAVLDLIKHLYPLRTCNLNLSPENIRAGKFKVCLEY
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCCCHHHHHHHH
HIKKCAGPCVGLQSHEDYLKNIDEIKEILKGNTQDISRMLVEKMQELANEMKFEEAQKIK
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKYLLIENYRSKSEVVSSVLHNIDVFSIEEDDSNSAFVNYLHITNGAINQAFTFEYKKKL
HHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHC
NESKEELLTLGIIEMRERYKSHSREIIVPFELDLELNNVVFTVPQRGDKKKLLDLSILNV
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECEEECCEEEECCCCCCCHHHHHHHHHHH
KQYKADRLKQAEKLNPEQRSMRLLKEIQNELHLDKPPLQIECFDNSNIQGSDAVAACVVF
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHH
KKAKPSKKDYRKYNIKTVVGPDDYASMKEVVRRRYQRAIEENSPLPDLIITDGGKGQMEV
HCCCCCHHHHHEECEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHH
VREVIEDELHLNIPIAGLAKDNKHRTSELLFGFPAQTIGIKQQSSLFRLLTQIQDEVHRF
HHHHHHCCCEECCCEEECCCCCCHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHH
AITFHRDKRSKRQVASALDSIKGIGEKTKTALLKEFKSVKRIKEASLEEIAKVIGEVKAQ
HHEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVKKGLSNE
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928