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The map label for this gene is mdmC [H]

Identifier: 29348249

GI number: 29348249

Start: 3542468

End: 3543106

Strand: Reverse

Name: mdmC [H]

Synonym: BT_2840

Alternate gene names: 29348249

Gene position: 3543106-3542468 (Counterclockwise)

Preceding gene: 29348250

Following gene: 29348248

Centisome position: 56.6

GC content: 45.7

Gene sequence:

>639_bases
ATGCAGGAGACTGAATCTATTGATGAATATATTTTGCAGCATATCGATGCGGAAAGTGACTATCTGAAAGCACTCTACCG
GGATACGCATGTGAAACTGCTTCGTCCCCGTATGGCTTCCGGGCATTTACAGGGGCGGATGCTGAAAATGTTTGTGGAGA
TGATTCGCCCCCGGCATATACTGGAGATCGGAACATATAGCGGTTATTCTGCCCTTTGTCTGGCGGAAGGCTTGTCGGAG
GGCGGAATGTTGCATACGTTTGAAATTAATGATGAACAAGAGGACTTTACCCGTCCCTGGCTGGAGAATTCTCCTTTTGC
GGACAAGATTCGCTTTTATATAGGAGATGCCTTGGAGCTTGTTCCTCATTTGGGCGTTACGTTCGATCTGGCCTTCATTG
ACGGTGATAAACGTAAATATATCGATTATTACGAGATGGTTTTAAAGCATCTTTCCACAGGTGGGTATATCATTGCCGAC
AATACATTGTGGGATGGTCATGTGTTGGAACAACCTCGTAGTGCGGATACGCAGACCATTGGCATCAAAGCATTCAATGA
CGCCCTTGTGACGGACGACCGGGTGGAGAAAGTAATCCTGCCTTTGCGTGATGGGTTAACTATAATAAGAAAAAAGTAA

Upstream 100 bases:

>100_bases
GAAATCAATGTCGTGGAAGATGCGTTGAAACATGCGGGAGAAACTGTATTGCCTAACAACAATCGTTATCTCTAACTGTT
ACATCTAAAATAAGGTTTTT

Downstream 100 bases:

>100_bases
GATAAGGAGTAAATTTATGGAAACAACCAGACAGAATAAGATATCCCGCCTGTTACAGAAGGAGCTGAGCGAGATATTCC
TGCTTCAGACAAAGGCAATG

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MQETESIDEYILQHIDAESDYLKALYRDTHVKLLRPRMASGHLQGRMLKMFVEMIRPRHILEIGTYSGYSALCLAEGLSE
GGMLHTFEINDEQEDFTRPWLENSPFADKIRFYIGDALELVPHLGVTFDLAFIDGDKRKYIDYYEMVLKHLSTGGYIIAD
NTLWDGHVLEQPRSADTQTIGIKAFNDALVTDDRVEKVILPLRDGLTIIRKK

Sequences:

>Translated_212_residues
MQETESIDEYILQHIDAESDYLKALYRDTHVKLLRPRMASGHLQGRMLKMFVEMIRPRHILEIGTYSGYSALCLAEGLSE
GGMLHTFEINDEQEDFTRPWLENSPFADKIRFYIGDALELVPHLGVTFDLAFIDGDKRKYIDYYEMVLKHLSTGGYIIAD
NTLWDGHVLEQPRSADTQTIGIKAFNDALVTDDRVEKVILPLRDGLTIIRKK
>Mature_212_residues
MQETESIDEYILQHIDAESDYLKALYRDTHVKLLRPRMASGHLQGRMLKMFVEMIRPRHILEIGTYSGYSALCLAEGLSE
GGMLHTFEINDEQEDFTRPWLENSPFADKIRFYIGDALELVPHLGVTFDLAFIDGDKRKYIDYYEMVLKHLSTGGYIIAD
NTLWDGHVLEQPRSADTQTIGIKAFNDALVTDDRVEKVILPLRDGLTIIRKK

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=173, Percent_Identity=34.1040462427746, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI6466450, Length=171, Percent_Identity=27.4853801169591, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI205830453, Length=171, Percent_Identity=27.4853801169591, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI205830451, Length=171, Percent_Identity=27.4853801169591, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI4502969, Length=171, Percent_Identity=27.4853801169591, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17565612, Length=218, Percent_Identity=29.3577981651376, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI72001127, Length=169, Percent_Identity=34.9112426035503, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI72001028, Length=214, Percent_Identity=31.3084112149533, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25148771, Length=169, Percent_Identity=33.7278106508876, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24380; Mature: 24380

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETESIDEYILQHIDAESDYLKALYRDTHVKLLRPRMASGHLQGRMLKMFVEMIRPRHI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCCCE
LEIGTYSGYSALCLAEGLSEGGMLHTFEINDEQEDFTRPWLENSPFADKIRFYIGDALEL
EEECCCCCCHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHH
VPHLGVTFDLAFIDGDKRKYIDYYEMVLKHLSTGGYIIADNTLWDGHVLEQPRSADTQTI
HHCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCEECCHHHCCCCCCCCEEE
GIKAFNDALVTDDRVEKVILPLRDGLTIIRKK
EEEECCCCCCCCHHHHHHHHHHHCCEEEEECC
>Mature Secondary Structure
MQETESIDEYILQHIDAESDYLKALYRDTHVKLLRPRMASGHLQGRMLKMFVEMIRPRHI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCCCE
LEIGTYSGYSALCLAEGLSEGGMLHTFEINDEQEDFTRPWLENSPFADKIRFYIGDALEL
EEECCCCCCHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHH
VPHLGVTFDLAFIDGDKRKYIDYYEMVLKHLSTGGYIIADNTLWDGHVLEQPRSADTQTI
HHCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCEECCHHHCCCCCCCCEEE
GIKAFNDALVTDDRVEKVILPLRDGLTIIRKK
EEEECCCCCCCCHHHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]