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The map label for this gene is nedA [H]

Identifier: 29347604

GI number: 29347604

Start: 2754557

End: 2755507

Strand: Reverse

Name: nedA [H]

Synonym: BT_2194

Alternate gene names: 29347604

Gene position: 2755507-2754557 (Counterclockwise)

Preceding gene: 29347605

Following gene: 29347603

Centisome position: 44.02

GC content: 47.95

Gene sequence:

>951_bases
ATGGCGGCAAGTGCGGTACTTTGTTCGTTTGCCTTGCTGAGTGGATGTAGTGATGATGATGTTTGTAAAGTATATATTCC
GGAAGCCAAAACTTTGCAGATTAAAAACTTCGATTTGGGTGAAGAACTGAGAGAAGTATTTCATGTGGCTGTGACTGCCA
GTGACTATGTGACCCGTTCCGGTAAGGAAGTGGGAGGAGATGTAAAGGTACAGTTGACTGTGGATGAGGCGAAGGTGCAG
GAGTATAATTCTTTGTGTGGGACAGACTATCCTTTGCTTCCTTCCGATTGCTATACGCTGACAACAGAAACTGTGATTCC
GGCCGGGGAGAGTTCTTCTGCCGATCTGGTGCTTACGGTAAATGCACAGGGAAAAATCCAGCCGTTTGATTCTTATTTGT
TGCCGGTCACTATCACTTCGGTAGAAGGTGCGCAGGCGGATCATATTCAGCAGACAGTATATTACCTTTTGAGTGGTGCG
GAGGATGTATGGGCGATGCCATTGGCCGACCGCAGTGCATGGCAGGTAGTAGAAGTTTCTTCGGAAGAGACGAGCGGCGA
AGGGTCGGATAACGGTCACGCTATCCACGCTTTTGACGGACTGAAAGGAACTTTCTGGCATACACAATGGAAAGGCAACG
AGCCTCAGCCACCACATCATATCGTAGTAGATATGGGGCAGGAAGTGAAAATGCTGGGCTTTCAGTATGTATCCAGAGAT
CATGGTGAAGCATGGCCGCAGGAGATGACGATGGAAACCAGTCTGGATGGCTCGAAGTGGGAGTCGGCAGGAACTTACAG
CGACCTTCCTGCGGGGGCAAAAGAGGAATTCCGTTCCTATTTTCCGGGATTTAAGCAGGCACGTTATTTCCGTCTGACAA
TAACTGCCGTGTATAGTGGCAAATGGGCAACAGTGGTAGCAGAGATTAATGCGATTTCTATTATTAAATAA

Upstream 100 bases:

>100_bases
AATGGTGGTGAAGACGGATGGGTAAACGGGCAGAATCCCGGATATTAATAAAGAATGTAAACCTTGAAAGATTATTCGTA
TGAAACTAAATAGATTTGTC

Downstream 100 bases:

>100_bases
CAGAAAAAACGATTACCATGAAAAAATACATTTATATACTTTTGACGTTCTGTCTGTTAATCTCCTGTATGGAAGATCCG
ACGGCAGGTGTGGTCGTTCC

Product: exo-alpha-sialidase

Products: NA

Alternate protein names: Neuraminidase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MAASAVLCSFALLSGCSDDDVCKVYIPEAKTLQIKNFDLGEELREVFHVAVTASDYVTRSGKEVGGDVKVQLTVDEAKVQ
EYNSLCGTDYPLLPSDCYTLTTETVIPAGESSSADLVLTVNAQGKIQPFDSYLLPVTITSVEGAQADHIQQTVYYLLSGA
EDVWAMPLADRSAWQVVEVSSEETSGEGSDNGHAIHAFDGLKGTFWHTQWKGNEPQPPHHIVVDMGQEVKMLGFQYVSRD
HGEAWPQEMTMETSLDGSKWESAGTYSDLPAGAKEEFRSYFPGFKQARYFRLTITAVYSGKWATVVAEINAISIIK

Sequences:

>Translated_316_residues
MAASAVLCSFALLSGCSDDDVCKVYIPEAKTLQIKNFDLGEELREVFHVAVTASDYVTRSGKEVGGDVKVQLTVDEAKVQ
EYNSLCGTDYPLLPSDCYTLTTETVIPAGESSSADLVLTVNAQGKIQPFDSYLLPVTITSVEGAQADHIQQTVYYLLSGA
EDVWAMPLADRSAWQVVEVSSEETSGEGSDNGHAIHAFDGLKGTFWHTQWKGNEPQPPHHIVVDMGQEVKMLGFQYVSRD
HGEAWPQEMTMETSLDGSKWESAGTYSDLPAGAKEEFRSYFPGFKQARYFRLTITAVYSGKWATVVAEINAISIIK
>Mature_315_residues
AASAVLCSFALLSGCSDDDVCKVYIPEAKTLQIKNFDLGEELREVFHVAVTASDYVTRSGKEVGGDVKVQLTVDEAKVQE
YNSLCGTDYPLLPSDCYTLTTETVIPAGESSSADLVLTVNAQGKIQPFDSYLLPVTITSVEGAQADHIQQTVYYLLSGAE
DVWAMPLADRSAWQVVEVSSEETSGEGSDNGHAIHAFDGLKGTFWHTQWKGNEPQPPHHIVVDMGQEVKMLGFQYVSRDH
GEAWPQEMTMETSLDGSKWESAGTYSDLPAGAKEEFRSYFPGFKQARYFRLTITAVYSGKWATVVAEINAISIIK

Specific function: To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 F5/8 type C domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018905
- InterPro:   IPR002860
- InterPro:   IPR000421
- InterPro:   IPR008979
- InterPro:   IPR013783
- InterPro:   IPR014756
- InterPro:   IPR011040
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02012 BNR; PF00754 F5_F8_type_C; PF10633 NPCBM_assoc [H]

EC number: =3.2.1.18 [H]

Molecular weight: Translated: 34631; Mature: 34500

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS50022 FA58C_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASAVLCSFALLSGCSDDDVCKVYIPEAKTLQIKNFDLGEELREVFHVAVTASDYVTRS
CCCHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHEEEECHHHHHCC
GKEVGGDVKVQLTVDEAKVQEYNSLCGTDYPLLPSDCYTLTTETVIPAGESSSADLVLTV
CCCCCCEEEEEEEECHHHHHHHHHHCCCCCCCCCCCCEEEEECEEEECCCCCCCCEEEEE
NAQGKIQPFDSYLLPVTITSVEGAQADHIQQTVYYLLSGAEDVWAMPLADRSAWQVVEVS
CCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEC
SEETSGEGSDNGHAIHAFDGLKGTFWHTQWKGNEPQPPHHIVVDMGQEVKMLGFQYVSRD
CCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCC
HGEAWPQEMTMETSLDGSKWESAGTYSDLPAGAKEEFRSYFPGFKQARYFRLTITAVYSG
CCCCCCHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHCEEEEEEEEEEECC
KWATVVAEINAISIIK
CEEEEEEECCEEEEEC
>Mature Secondary Structure 
AASAVLCSFALLSGCSDDDVCKVYIPEAKTLQIKNFDLGEELREVFHVAVTASDYVTRS
CCHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHEEEECHHHHHCC
GKEVGGDVKVQLTVDEAKVQEYNSLCGTDYPLLPSDCYTLTTETVIPAGESSSADLVLTV
CCCCCCEEEEEEEECHHHHHHHHHHCCCCCCCCCCCCEEEEECEEEECCCCCCCCEEEEE
NAQGKIQPFDSYLLPVTITSVEGAQADHIQQTVYYLLSGAEDVWAMPLADRSAWQVVEVS
CCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEC
SEETSGEGSDNGHAIHAFDGLKGTFWHTQWKGNEPQPPHHIVVDMGQEVKMLGFQYVSRD
CCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCC
HGEAWPQEMTMETSLDGSKWESAGTYSDLPAGAKEEFRSYFPGFKQARYFRLTITAVYSG
CCCCCCHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHCEEEEEEEEEEECC
KWATVVAEINAISIIK
CEEEEEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400240; 8591030 [H]