Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 29347481

GI number: 29347481

Start: 2593087

End: 2594277

Strand: Reverse

Name: icd [H]

Synonym: BT_2071

Alternate gene names: 29347481

Gene position: 2594277-2593087 (Counterclockwise)

Preceding gene: 29347482

Following gene: 161511190

Centisome position: 41.44

GC content: 52.23

Gene sequence:

>1191_bases
ATGAACAAAATAACCATGCAAAAAGATGGTACGCTATCGGTGCCCGATGTGCCTGTCGTACCTTATATTACCGGAGACGG
AGTAGGAGCGGAAGTGACTCCGTCGATGCAGTCCGTTGTGAACGCGGCTGTTCAGAAAGCATACGGCGGCAAACGTCGGA
TTGAATGGAAAGAAGTGCTGGCGGGCGAACGCGCTTTCAACGAGACAGGTTCGTGGTTGCCGGATGAAACGATGAAGGCT
TTCCAAGAATATCTGATCGGCATCAAGGGGCCGCTGACGACCCCTGTCGGCGGTGGAATCCGTTCTTTGAACGTGGCTTT
GCGCCAAACTCTGGATTTGTATGTTTGTCTGCGTCCGGTCCGTTGGTATCAAGGCGTTCATTCTCCGGTGAAAGCACCGG
AAAAAGTGAACATGTGCGTGTTCCGTGAAAATACGGAGGATATATATGCAGGAATCGAGTGGGAGGCAGGTACTCCCGAA
GCCGAAAAGTTCTATCAATTCCTGAAAAACGAGATGGGAGTGACGAAAGTCCGCTTCCCCGAGACCTCTTCTTTTGGAGT
GAAACCTGTTTCCCGTGAGGGCACGGAACGTCTTGTGCGGGCTGCCTGCCAGTATGCGCTCGACCATCATCTGCCTTCCG
TGACACTGGTGCACAAAGGAAACATTATGAAGTTCACCGAAGGAGGCTTCAAGAAATGGGGCTATGAGCTGGCGCAACGT
GAGTTCGGCGACGCCTTGGCAGACGGCCGGTTGGTGATAAAGGACTGCATCGCCGATGCTTTCCTGCAAAATACATTACT
GATTCCCGAAGAATATTCCGTGATTGCCACGCTGAACCTGAACGGAGACTACGTTTCCGACCAGTTGGCGGCAATGGTAG
GCGGCATCGGCATTGCTCCGGGAGCAAATATTAACTACAAGACGGGGCACGCCATTTTTGAAGCGACTCATGGAACCGCC
CCCAACATTGCCGGAAAGGATGTCGTGAATCCTTGTTCTATCATTCTTTCGGCGGTGATGATGCTTGAATATCTGGGATG
GAAAGAAGCGGCCGCGCTTATCGAAAAGGCGTTGGAACAGAGTTTCCTCGATGCCCGTGCCACGCACGATCTGGCTCGCT
TTATGCCGGGAGGTACATCCCTGTCTACCACCGCTTTCACACGCGAAATTGTGGAAAGAATCGAAAAGTAA

Upstream 100 bases:

>100_bases
CGAAAGAGAGTTTTGAAGCGCAACATACATACAACGAACAGCAGATTGCCTGGTTCCGTGCCGGCTCTGCCTTGAATGCC
AGATAATTAAAATGATAGAA

Downstream 100 bases:

>100_bases
ATGTAACGATTAAAAACGAAGTATTATGAAGAAAGAGTATTTGATTTACAAGCTCTCCGAGGAGATGAAAGAGGCAACCC
GGATTGACAATGAATTGTTC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MNKITMQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQSVVNAAVQKAYGGKRRIEWKEVLAGERAFNETGSWLPDETMKA
FQEYLIGIKGPLTTPVGGGIRSLNVALRQTLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPE
AEKFYQFLKNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNIMKFTEGGFKKWGYELAQR
EFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGGIGIAPGANINYKTGHAIFEATHGTA
PNIAGKDVVNPCSIILSAVMMLEYLGWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK

Sequences:

>Translated_396_residues
MNKITMQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQSVVNAAVQKAYGGKRRIEWKEVLAGERAFNETGSWLPDETMKA
FQEYLIGIKGPLTTPVGGGIRSLNVALRQTLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPE
AEKFYQFLKNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNIMKFTEGGFKKWGYELAQR
EFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGGIGIAPGANINYKTGHAIFEATHGTA
PNIAGKDVVNPCSIILSAVMMLEYLGWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK
>Mature_396_residues
MNKITMQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQSVVNAAVQKAYGGKRRIEWKEVLAGERAFNETGSWLPDETMKA
FQEYLIGIKGPLTTPVGGGIRSLNVALRQTLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPE
AEKFYQFLKNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNIMKFTEGGFKKWGYELAQR
EFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGGIGIAPGANINYKTGHAIFEATHGTA
PNIAGKDVVNPCSIILSAVMMLEYLGWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=383, Percent_Identity=33.6814621409922, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4758582, Length=348, Percent_Identity=27.8735632183908, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI28178838, Length=348, Percent_Identity=27.8735632183908, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI28178821, Length=381, Percent_Identity=25.7217847769029, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI28178816, Length=342, Percent_Identity=26.3157894736842, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI28178819, Length=212, Percent_Identity=29.7169811320755, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787381, Length=407, Percent_Identity=59.4594594594595, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1788101, Length=363, Percent_Identity=29.2011019283747, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87081683, Length=387, Percent_Identity=27.1317829457364, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71986051, Length=381, Percent_Identity=34.3832020997375, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI25144293, Length=384, Percent_Identity=28.90625, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17505779, Length=346, Percent_Identity=28.3236994219653, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17550882, Length=331, Percent_Identity=25.3776435045317, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324709, Length=380, Percent_Identity=32.1052631578947, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324291, Length=378, Percent_Identity=31.2169312169312, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322097, Length=383, Percent_Identity=31.0704960835509, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319830, Length=401, Percent_Identity=26.9326683291771, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24643270, Length=376, Percent_Identity=32.9787234042553, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24643268, Length=376, Percent_Identity=33.2446808510638, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24661184, Length=377, Percent_Identity=30.7692307692308, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI161078637, Length=297, Percent_Identity=32.6599326599327, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161078635, Length=297, Percent_Identity=32.6599326599327, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161078633, Length=297, Percent_Identity=32.6599326599327, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24650122, Length=297, Percent_Identity=32.6599326599327, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI161078639, Length=297, Percent_Identity=32.6599326599327, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI281362242, Length=375, Percent_Identity=27.7333333333333, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24648872, Length=375, Percent_Identity=27.7333333333333, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI20130355, Length=345, Percent_Identity=23.768115942029, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 43440; Mature: 43440

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKITMQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQSVVNAAVQKAYGGKRRIEWKEVL
CCCEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
AGERAFNETGSWLPDETMKAFQEYLIGIKGPLTTPVGGGIRSLNVALRQTLDLYVCLRPV
HCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPEAEKFYQFLKNEMGVTKVRFP
HHHHCCCCCCCCCCCCCEEEEECCCCHHEECEEECCCCCCHHHHHHHHHHCCCCEEEECC
ETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNIMKFTEGGFKKWGYELAQR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHHHH
EFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGGIGIAP
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCC
GANINYKTGHAIFEATHGTAPNIAGKDVVNPCSIILSAVMMLEYLGWKEAAALIEKALEQ
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKITMQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQSVVNAAVQKAYGGKRRIEWKEVL
CCCEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
AGERAFNETGSWLPDETMKAFQEYLIGIKGPLTTPVGGGIRSLNVALRQTLDLYVCLRPV
HCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPEAEKFYQFLKNEMGVTKVRFP
HHHHCCCCCCCCCCCCCEEEEECCCCHHEECEEECCCCCCHHHHHHHHHHCCCCEEEECC
ETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNIMKFTEGGFKKWGYELAQR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHHHH
EFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGGIGIAP
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCC
GANINYKTGHAIFEATHGTAPNIAGKDVVNPCSIILSAVMMLEYLGWKEAAALIEKALEQ
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA